Cannabidiol nasal preparation for treating post-traumatic stress disorder

A post-traumatic stress and cannabidiol technology, applied in the field of cannabidiol preparations for the treatment of post-traumatic stress disorder, can solve problems such as blood and lymphatic system discomfort, side effects that cannot be ignored, and immune disorders

Inactive Publication Date: 2019-11-12
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the treatment of PTSD, serotonin reuptake inhibitors (Selective Serotonin Reuptake Inhibitor, SSRI) are the first choice at present, among which fluoxetine, paroxetine, and sertraline have better curative effects, but the side effects caused by long-term medication can not be ignored, common Nausea, headache, insomnia, severe cases can also cause blood and lymphatic system discomfort, immune disorders, sexual dysfunction, etc.

Method used

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  • Cannabidiol nasal preparation for treating post-traumatic stress disorder
  • Cannabidiol nasal preparation for treating post-traumatic stress disorder
  • Cannabidiol nasal preparation for treating post-traumatic stress disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Cannabidiol nasal thermosensitive gel

[0032] Take 2g of poloxamer 188 and 12g of poloxamer 407, add appropriate amount of water to fully swell at 4°C, continue to add water to 50ml, and mix well to obtain a blank thermosensitive gel; take 1g of cannabidiol, add 6mL of 1,2-propanediol and 8mL ethanol to make it fully dissolved; add the cannabidiol solution to 36mL of the above-mentioned blank temperature-sensitive gel, and mix well to obtain a cannabidiol nasal preparation. At 4°C, the appearance of the nasal temperature-sensitive gel composition is colorless, transparent and viscous solution, which turns into a gel state at 35°C ( figure 1 ).

experiment example 1

[0033] Experimental Example 1: Pharmacodynamic evaluation of cannabidiol nasal thermosensitive gel in the treatment of post-traumatic stress disorder

[0034] 1 Materials and methods:

[0035] 1.1 Experimental animals and grouping: Male C57 mice, SPF grade, 20±1g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., were randomly divided into normal group, model group, and cannabidiol thermosensitive gel group, each group 3 Only.

[0036] 1.2 Construction of animal model: the mice in the normal group were placed in the conditioned fear box to move freely for 600s without any stimulation, and the mice in the model group and the administration group were stimulated as follows: set the current to 0.8mA, put the mice in the fear box Within 300s of free movement, the electric stimulation stage was entered, which lasted for 10s, with an interval of 10s, and 15 electric shocks. After each animal experiment, spray alcohol on a paper towel and wipe it clean t...

Embodiment 2

[0047] Example 2 Cannabidiol, hydroxypropyl-β-cyclodextrin inclusion compound composition

[0048] Accurately weigh 0.5g of hydroxypropyl-β-cyclodextrin in a 50mL beaker, add 10mL of ultrapure water and stir to dissolve to obtain 50mg·mL -1 Hydroxypropyl-β-cyclodextrin solution; accurately weigh 0.1g of cannabidiol in a centrifuge tube, add 10mL of tert-butanol solution and ultrasonically dissolve to obtain 10mg·mL -1 Cannabidiol tert-butanol solution; slowly inject the cannabidiol tert-butanol solution into the hydroxypropyl-β-cyclodextrin solution under magnetic stirring conditions, mix well, and freeze-dry in a freeze dryer for 42 hours. Obtain cannabidiol hydroxypropyl-β-cyclodextrin inclusion compound. Infrared results proved that after cannabidiol formed an inclusion compound, the characteristic absorption peak disappeared ( Figure 5 ), proving that cannabidiol was successfully encapsulated into the cavity of hydroxypropyl-β-cyclodextrin. And as the concentration of ...

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to preparation of a cannabidiol nasal preparation composition for treating post-traumatic stress disorder, and temperature sensitive gel, ion sensitive gel, cubic liquid crystals, and the like are included; the cannabidiol nasal preparation composition has high adhesion in a nasal cavity, residence time isprolonged in the nasal cavity, bioavailability is improved beneficially to exert the pharmacological effect, and brain targeting is achieved; at the same time, the preparation process is simple, stability is high, and compliance of the patient is good; and pharmacodynamic tests prove that the cannabidiol nasal preparation for treating the post-traumatic stress disorder has good anti-depressant andanti-anxiety effects, and can be used for treating the post-traumatic stress disorder.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a cannabidiol preparation for treating post-traumatic stress disorder. Background technique [0002] Post-traumatic stress disorder (PTSD) refers to a mental disorder that delays the emergence of the body or persists for a long time after an individual experiences or witnesses an unusually catastrophic event (earthquake, flood, war, car accident, etc.) . The clinical manifestations of PTSD mainly include traumatic re-experiencing symptoms, avoidance and numbness symptoms, and increased alertness symptoms. For the treatment of PTSD, serotonin reuptake inhibitors (Selective Serotonin Reuptake Inhibitor, SSRI) are the first choice at present, among which fluoxetine, paroxetine, and sertraline have better curative effects, but the side effects caused by long-term medication can not be ignored, common Nausea, headache, insomnia, severe cases can also cause blood and lympha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/127A61K9/10A61K47/69A61K47/18A61K47/10A61K47/14A61K31/05A61P25/24A61P25/22
CPCA61K9/06A61K9/1274A61K9/10A61K9/0043A61K47/6951A61K47/183A61K47/14A61K47/10A61K31/05A61P25/24A61P25/22
Inventor 杜丽娜金义光庞璐璐
Owner ACADEMY OF MILITARY MEDICAL SCI
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