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Herba houttuyniae volatile oil liposome preparation and preparation method and usage thereof

A technology of liposome preparation and Houttuynia cordata, applied in the field of medicine, can solve the problems of no industrial production, no mass product production, etc., and achieve the effects of improved safety, good clinical application prospect and good curative effect

Inactive Publication Date: 2018-08-17
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Since the supercritical CO2 rapid expansion method is only a tentative exploration and application based on supercritical CO2, it does not have the possibility of industrial production at present. The preparation of Houttuynia cordata volatile oil by this method is only a small laboratory test, and currently does not have large quantities. possibility of production

Method used

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  • Herba houttuyniae volatile oil liposome preparation and preparation method and usage thereof
  • Herba houttuyniae volatile oil liposome preparation and preparation method and usage thereof
  • Herba houttuyniae volatile oil liposome preparation and preparation method and usage thereof

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Embodiment 1

[0028] Embodiment 1 Preparation method of the present invention

[0029] 1. Preparation of Houttuynia volatile oil liposome

[0030] Liposome prescription: Houttuynia cordata volatile oil 4g, phospholipid 15g, cholesterol 5g.

[0031] Preparation Process:

[0032] Weigh 15g of PC, add 1000ml of phosphate buffer solution (pH7.4) and stir to dissolve, and weigh CH5g in proportion, dissolve it with a small amount of ether, drop it into the PC solution kept at 60-70℃ with a dropper, and stir Mix evenly, ultrasonically treat for 30min, ultrasonic power is 60w; add 4g volatile oil solution, and then ultrasonically treat for 30min, ultrasonic power is 60w, then the suspension is passed through a high-pressure milk homogenizer twice, and filtered to obtain the volatile oil liposome.

[0033] The extraction method of Houttuynia cordata volatile oil among the present invention is as follows:

[0034] Grind the dried Houttuynia cordata into a coarse powder, weigh 100g, put it into a 2...

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Abstract

The invention provides a herba houttuyniae volatile oil liposome preparation. The herba houttuyniae volatile oil liposome preparation contains liposome formed by phospholipid and cholesterol and herbahouttuyniae volatile oil encapsulated by the liposome, wherein a weight ratio of the phospholipid and cholesterol is 2-4:1, and a weight ratio of the liposome and the herba houttuyniae volatile oil is 5:1. The herba houttuyniae volatile oil liposome can be used for preparing a nasal preparation, the safety is greatly improved, and the curative effect is good. The herba houttuyniae volatile oil liposome can be enriched in a respiratory tract better after absorbed by a nose so that the good local action is achieved, and absorbed into the blood circulation through respiratory region mucous membranes, the whole body therapeutic action is achieved, so the preparation has the good clinic application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a liposome preparation of Houttuynia cordata volatile oil and its preparation method and application. Background technique [0002] Houttuynia cordata is the whole herb of the genus Houffuynia Cordata Thunb., which has the effects of clearing away heat and detoxification, eliminating carbuncle and draining pus, and diuresis for treating stranguria. Modern pharmacological verification: Houttuynia cordata has extensive antibacterial and antiviral effects, and its antibacterial and antiviral active substances are volatile oils, which have a better effect on treating respiratory tract infections. [0003] At present, the preparations using Houttuynia cordata mostly extract its volatile oil components to prepare injections, but it is found in clinical use that it is very prone to adverse reactions. Studies have shown that liposomes can reduce drug toxicity, improve drug ...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K9/127A61P11/00
CPCA61K9/0043A61K9/127A61K36/78A61K2236/331A61P11/00
Inventor 李楠
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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