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Nasal preparation for treating white-plus disease and preparation method thereof

A technology for white pulse disease and nasal use, which is applied in the field of nasal preparations for white pulse disease and its preparation, and can solve problems affecting product efficacy and promotion, poor drug penetration ability, and unstable production process, etc.

Active Publication Date: 2010-05-12
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the records of "Four Medical Codes" and "Jingzhu Materia Medica", combined with long-term practical experience, the Tibetan people use turmeric, nutmeg, nard pine, actinolite, licorice, kaempferen, musk, Tibetan fennel, pepper, and alkali flower as raw materials The produced Tibetan medicine Baimai ointment is trusted by the majority of patients for its remarkable quality and effect. However, the traditional preparation process of Tibetan medicine Baimai ointment is to mix all the raw medicinal materials into fine powders to make ointment. The process is complicated and the batch production cycle is long. The production process is unstable; the sources of raw materials and excipients are unstable, which is not conducive to industrial production; some drugs have poor penetration ability and low bioavailability, and the curative effect cannot be fully guaranteed, so it is not suitable to exert the curative effect of the drug; in addition, the product is not suitable for storage and is inconvenient to carry; The reason has greatly affected the curative effect and promotion of the product

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  • Nasal preparation for treating white-plus disease and preparation method thereof
  • Nasal preparation for treating white-plus disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0213] Embodiment 1: nasal preparation of the present invention

[0214] Raw material composition:

[0215] 36.3g of turmeric, 12.1g of nutmeg, 19.4g of nard pine, 12.1g of actinolite, 17.0g of licorice, 0.17g of artificial musk, 24.2g of dried ginger, 31.5g of Tibetan fennel, 17.0g of Tibetan calamus, 12.1g of Chinese prickly ash, alkali flower 18.2g;

[0216] Excipient composition:

[0217] Borax sodium carbonate buffer 580ml, glycerin 30g, sodium chloride 30g, sodium sulfite 10g, sodium bicarbonate solution 15ml, sodium benzoate 3.0g;

[0218] Preparation method:

[0219] ① Grind artificial musk into fine powder;

[0220] ② Pick and clean turmeric, nutmeg, dried pine, actinolite, licorice, dried ginger, Tibetan fennel, Tibetan calamus, Zanthoxylum bungeanum and Alkali flower, and crush them into superfine powder with a particle size of 0.1-1 μm;

[0221] ③Mix the superfine powder obtained in the above step ② with the artificial musk fine powder obtained in step ①, add ...

Embodiment 2

[0222] Embodiment 2: nasal preparation of the present invention

[0223] Raw material composition:

[0224] Turmeric 36.3g, Nutmeg 12.1g, Nardin 19.4g, Actinolite 12.1g, Licorice 17.0g, Musk 0.17g, Dried Ginger 24.2g, Tibetan Fennel 31.5g, Tibetan Calamus 17.0g, Zanthoxylum bungeanum 12.1g, Alkali flower 18.2 g;

[0225] Excipient composition:

[0226] Phosphate buffer 550ml, propylene glycol 12g, glucose 17.5g, sodium metabisulfite 10g, disodium hydrogen phosphate solution 10ml, methylparaben 2.5g;

[0227] Preparation method:

[0228] ① Grind musk into fine powder;

[0229] ② Pick and clean turmeric, nutmeg, dried pine, actinolite, licorice, dried ginger, Tibetan fennel, Tibetan calamus, Chinese prickly ash and alkali flower, and crush them into superfine powder with a particle size of 1-10 μm;

[0230] ③Mix the superfine powder obtained in the above step ② with the musk powder obtained in step ① evenly, add phosphate buffer saline, propylene glycol, glucose, sodium met...

Embodiment 3

[0231] Embodiment 3: nasal preparation of the present invention

[0232] Raw material composition:

[0233] 36.3g of turmeric, 12.1g of nutmeg, 19.4g of nard pine, 12.1g of actinolite, 17.0g of licorice, 0.17g of artificial musk, 24.2g of dried ginger, 31.5g of Tibetan fennel, 17.0g of Tibetan calamus, 12.1g of Chinese prickly ash, alkali flower 18.2g;

[0234] Excipient composition:

[0235] Borate buffer 600ml, ethanol 15g, mannitol 20g, sodium bisulfite 18g, sodium hydroxide solution 20ml, sorbic acid 2.5g;

[0236] Preparation method:

[0237] ① Grind artificial musk into fine powder;

[0238] ② Pick turmeric, nutmeg, dried pine, actinolite, licorice, dried ginger, Tibetan fennel, Tibetan calamus, peppercorns and alkali flowers, and crush them into ultrafine powders with a particle size of 10-40 μm;

[0239] ③Mix the superfine powder obtained in the above step ② with the artificial musk fine powder obtained in step ①, add borate buffer solution, ethanol, mannitol, sod...

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Abstract

The invention discloses a nasal preparation for treating white-plus disease and a preparation method thereof. The nasal preparation is prepared by taking a formula of the conventional Tibetan medicament white-plus unguent as a basic formula and modifying the formulation. In the invention, an adopted preparation method of extracting some medicinal materials and making other medicinal materials into superfine powder effectively retains the active ingredients of the medicinal materials, greatly improves the raw medicament component content and improves bioavailability so that the curative effect of the preparation is better. The auxiliary material selected and applied in the invention has good moldability so that a product has good permeability, better absorption and quicker response and the advantages of convenient administration, long duration, low allergy rate, convenient usage and carrying, no pollution to clothes and the like; and in the invention, a nasal mucosa administration system is adopted, so that the preparation has quick absorption, quick response, no stimulation nor unpleasant odor.

Description

field of invention [0001] The invention relates to a nasal preparation and a preparation method thereof, in particular to a nasal preparation for treating leukemia and a preparation method thereof. technical background [0002] Baimai Ointment is a classic Tibetan medicine prescription composed of Tibetan folk doctors based on the records of "Tibetan Medicine and Supplements" and "Four Medical Codes", combined with practical experience. Baimai Ointment was originally recorded in "Drug Standards Issued by the Ministry of Health" Page 310 of the first volume of Tibetan medicine in the 1995 edition. The prescription of Baimai ointment is: [0003] 150g turmeric, 50g nutmeg, 80g nard pine, 50g actinolite, 70g licorice, 0.7g artificial musk or musk, 100g kaempferen, 130g Tibetan fennel, 70g Tibetan calamus, 50g pepper, 75g alkali flower. [0004] Preparation method: the above eleven flavors, except artificial musk or musk which are ground into fine powder, the rest are ground i...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P19/00A61P19/04A61P25/00A61K35/55A61K33/26A61K33/00A61K31/122
Inventor 陈丽娟张樱山张国霞李波
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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