A self-carrying carrier-free nasal cavity nano-preparation brain-targeted delivery system modified with chitosan oligosaccharides and its preparation method

A nano-preparation and chitosan oligosaccharide technology, which is applied in the field of biomedicine, can solve the problems of low bioavailability, difficulty in crossing the blood-brain barrier, and poor druggability, and achieve high bioavailability, easy self-medication, and fast onset of action. Effect
CN109730966BActive Publication Date: 2021-06-25NASAL PHYTO SZ PHARMA TECH CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
NASAL PHYTO SZ PHARMA TECH CO LTD
Publication Date
2021-06-25

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Abstract

The invention discloses a self-carrying carrier-free nasal cavity nano-preparation brain-targeted delivery system modified by chitosan oligosaccharides and a preparation method thereof. Including hydrophobic small molecule drugs with neuroprotective effects, polyethylene glycol derivatives, and chitosan oligosaccharides. The present invention also provides a preparation method for the brain-targeted delivery system of the nasal cavity nano-preparation. The first step is to prepare the freeze-dried powder of nanoparticles, and the second step is to stir the freeze-dried powder and chitosan oligosaccharide in isotonic saline before use to form a nasal cavity preparation with good membrane permeability. The preparation method of the system of the present invention is simple, can improve the hydrophobicity of small molecule drugs, reduce toxicity, and enhance neuroprotective effect; there is no carrier, no biodegradation problem and accumulation toxicity, the drug loading rate is as high as 25%, and the membrane is permeable after being modified by chitosan oligosaccharides Absorption is good, and the drug is delivered into the brain with high targeting. The administration method of the dosage form is nasal drop, spray, etc., and the operation is simple, which is convenient for patients who take medicine for a long time, and has a good application prospect in the treatment of nervous system diseases.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to a nasal cavity nano-preparation brain-targeted delivery system and a preparation method thereof. Specifically, it is a chitosan oligosaccharide-modified, self-carrying carrier-free nasal cavity nano-preparation brain-targeted delivery system and a preparation method thereof. Background technique

[0002] In recent years, the incidence of neurological diseases has been increasing year by year, and there is a severe shortage of therapeutic drugs. Most of the small molecules with neuroprotective activity screened out by drug research and development are hydrophobic small organic molecules, which are difficult to dissolve in water, have low bioavailability in the body, short blood circulation time and instability. its clinical application.

[0003] For example, curcumin has been reported to have significant neuroprotective pharmacological activity in vitro, but its in vivo application is l...

Claims

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