Nasal preparation for treating rhinitis and its preparation method and application

A technology for nasal use and preparation, which is applied in the field of nasal preparation for treating rhinitis and its preparation field, can solve the problems of unsatisfactory anti-inflammatory and anti-allergic effects, large dosage, single dosage form, etc., and achieves no toxic side effects and bioavailability. High, easy patient compliance

Active Publication Date: 2017-12-01
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a nasal preparation for treating rhinitis and its preparation method and application, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the unsatisfactory anti-inflammatory and anti-allergic effects of existing preparations. , and the problem of taking a large dose

Method used

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  • Nasal preparation for treating rhinitis and its preparation method and application
  • Nasal preparation for treating rhinitis and its preparation method and application
  • Nasal preparation for treating rhinitis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1, the raw material of the nasal preparation for treating rhinitis contains 70 to 150 parts of Artemisia xinjiang, 90 to 180 parts of fried cocklebur, 20 to 80 parts of Angelica dahurica, and 5 to 60 parts of ephedra 10 to 60 parts of Scutellaria baicalensis extract, 1 to 50 parts of licorice extract, 0.1 to 10 parts of mint oil, 0.1 to 5 parts of Tween-80, and 5 to 60 parts of excipients.

[0029] Artemisia rupestris L. is the medicinal whole herb of Artemisia rupestris L., a perennial herb of the genus Artemisia in the family Asteraceae. Xanthium is the dry ripe fruit with involucre of Xanthium sibicum Patr.

[0030] Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan root.

[0031]Ephedra is the dry herbaceous stem of Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A.Mey. or Ephedra equisetina Bge.

[0032] Most of the traditional medicines currently on the market for the treatment of rhinitis are oral medicines. O...

Embodiment 2

[0033] Example 2, the raw material of the nasal preparation for treating rhinitis contains 70 or 150 parts of Artemisia xinjiang, 90 or 180 parts of fried cocklebur, 20 or 80 parts of Angelica dahurica, 5 or 60 parts of ephedra 10 or 60 parts of Scutellaria baicalensis extract, 1 or 50 parts of licorice extract, 0.1 or 10 parts of peppermint oil, 0.1 or 5 parts of Tween-80, 5 or 60 parts of excipients.

Embodiment 3

[0034] Example 3, the nasal preparation for the treatment of rhinitis is obtained according to the following preparation method: first step, grind the required amount of Artemisia xinjiang, fried cocklebur, angelica dahurica and ephedra and mix them evenly to obtain a mixture; In the second step, the mixed material is refluxed with water or ethanol aqueous solution for 1 to 4 times, and after reflux extraction, the extracts obtained each time are combined to obtain a mixed extract; in the third step, the mixed extract is sequentially volatilized with ethanol and concentrated under reduced pressure , to obtain an extract; the fourth step, the required amount of Scutellaria baicalensis extract with NaHCO 3 After the aqueous solution is dissolved, add the primary extract and mix evenly to obtain the first mixed solution; in the fifth step, add the required amount of licorice extract with water or NaHCO 3 After the aqueous solution is dissolved, then add the first mixed solution a...

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Abstract

The invention relates to the technical field of nasal preparation, and relates to a nasal preparation for treating rhinitis and its preparation method and application. The nasal preparation for treating rhinitis is prepared from, by weight, artemisia rupestris, fried cocklebur fruit, radix angelicae, ephedra, scutellaria baicalensis extract, extractum glycyrrhizae, dementholized peppermint oil, tween-80, and ingredients. The nasal preparation for treating rhinitis is prepared by combining ethnic medicine theory with traditional Chinese medicine theory; compared with the prior art, the dosage of the nasal preparation for treating rhinitis is only 20-30% of that in the prior art; moreover, the nasal preparation for treating rhinitis has significant effects in anti-inflammatory and antiallergic by comparing with the prior art; meanwhile, the nasal preparation is simple in preparation technique, accurate in treatment effect, free from toxic and side effects; the drug is directly effected on the surface of the nasal mucosa; thus the nasal preparation is high in bioavailability, quick and convenient to take effect and good in patient compliance; different dosage forms can be prepared upon patient's demand, thus the nasal preparation can be better applied to treat acute, chronic and allergic rhinitis.

Description

technical field [0001] The invention relates to the technical field of nasal preparations, and relates to a nasal preparation for treating rhinitis, a preparation method and application thereof. Background technique [0002] Rhinitis is an inflammation of the nasal mucosa caused by allergens, viruses, bacteria, various physical and chemical factors, and even certain systemic diseases, commonly known as nasal inflammatory diseases. With the modernization of urban life, automobile exhaust, decorative materials and food additives, etc., are the main causes of rhinitis (including allergic rhinitis, chronic rhinitis, chronic sinusitis, etc.). In recent years, the incidence of allergic rhinitis has a global increase trend, which is regarded as "the epidemic of the 21st century". Its global average incidence is 10% to 25%. Although not life-threatening, nasal symptoms, eye symptoms, and related organ symptoms (bronchial asthma, otitis media, etc.) caused by allergic rhinitis can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61K47/26A61P11/02A61P37/08
CPCA61K9/0043A61K36/17A61K36/232A61K36/28A61K36/484A61K36/534A61K36/539A61K47/26A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 顾政一刘燕毛艳贺金华陈振东肖女
Owner XINJIANG INST OF MATERIA MEDICA
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