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Nasal preparation for treating rhinitis and its preparation method and application

A technology for nasal preparations, applied in the field of nasal preparations for rhinitis and its preparation, which can solve the problems of unsatisfactory anti-inflammatory and anti-allergic effects, single dosage form, large dosage, etc., achieves no toxic side effects, and is convenient for patients to follow Sexuality and high bioavailability

Active Publication Date: 2021-02-12
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a nasal preparation for treating rhinitis and its preparation method and application, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the unsatisfactory anti-inflammatory and anti-allergic effects of existing preparations. , and the problem of taking a large dose

Method used

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  • Nasal preparation for treating rhinitis and its preparation method and application
  • Nasal preparation for treating rhinitis and its preparation method and application
  • Nasal preparation for treating rhinitis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1, the raw material of the nasal preparation for treating rhinitis contains 70 to 150 parts of Artemisia xinjiang, 90 to 180 parts of fried cocklebur, 20 to 80 parts of Angelica dahurica, and 5 to 60 parts of ephedra 10 to 60 parts of Scutellaria baicalensis extract, 1 to 50 parts of licorice extract, 0.1 to 10 parts of mint oil, 0.1 to 5 parts of Tween-80, and 5 to 60 parts of excipients.

[0029] Artemisia rupestris L. is the medicinal whole herb of Artemisia rupestris L., a perennial herb of the genus Artemisia in the family Asteraceae. Xanthium is the dry ripe fruit with involucre of Xanthium sibicum Patr.

[0030] Angelica dahurica (Fisch.ex Hoffm.) Benth.EtHook. or Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan root.

[0031]Ephedra is the dry herbaceous stem of Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A.Mey. or Ephedra equisetina Bge.

[0032] Most of the traditional medicines currently on the marke...

Embodiment 2

[0033] Example 2, the raw material of the nasal preparation for treating rhinitis contains 70 or 150 parts of Artemisia xinjiang, 90 or 180 parts of fried cocklebur, 20 or 80 parts of Angelica dahurica, 5 or 60 parts of ephedra 10 or 60 parts of Scutellaria baicalensis extract, 1 or 50 parts of licorice extract, 0.1 or 10 parts of peppermint oil, 0.1 or 5 parts of Tween-80, 5 or 60 parts of excipients.

Embodiment 3

[0034] Example 3, the nasal preparation for the treatment of rhinitis is obtained according to the following preparation method: first step, grind the required amount of Artemisia xinjiang, fried cocklebur, angelica dahurica and ephedra and mix them evenly to obtain a mixture; In the second step, the mixed material is refluxed with water or ethanol aqueous solution for 1 to 4 times, and after reflux extraction, the extracts obtained each time are combined to obtain a mixed extract; in the third step, the mixed extract is sequentially volatilized with ethanol and concentrated under reduced pressure , to obtain an extract; the fourth step, the required amount of Scutellaria baicalensis extract with NaHCO 3 After the aqueous solution is dissolved, add the primary extract and mix evenly to obtain the first mixed solution; in the fifth step, add the required amount of licorice extract with water or NaHCO 3 After the aqueous solution is dissolved, then add the first mixed solution a...

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Abstract

The invention relates to the technical field of nasal preparations, and relates to a nasal preparation for treating rhinitis and its preparation method and application; the raw materials contain Xinjiang Artemisia chinensis, fried cocklebur, angelica dahurica, ephedra, scutellaria baicalensis extracts, Licorice extract, peppermint oil, Tween-80, excipients. The nasal preparation for treating rhinitis of the present invention is composed according to the theory of national medicine and traditional Chinese medicine. Compared with the prior art, the dosage of the nasal preparation for treating rhinitis of the present invention is only 20% of the dosage of the prior art. % to 30%, and the nasal preparation for the treatment of rhinitis of the present invention is more effective in anti-inflammation and anti-allergy than the prior art; meanwhile, the preparation process of the present invention is simple and convenient, has definite curative effect, no toxic and side effects, and the medicine directly acts on the nasal mucosa On the surface, it has high bioavailability, quick onset, convenience and good patient compliance. Different dosage forms can be prepared according to the needs of patients, which can be better used to treat acute, chronic and allergic rhinitis.

Description

technical field [0001] The invention relates to the technical field of nasal preparations, and relates to a nasal preparation for treating rhinitis, a preparation method and application thereof. Background technique [0002] Rhinitis is an inflammation of the nasal mucosa caused by allergens, viruses, bacteria, various physical and chemical factors, and even certain systemic diseases, commonly known as nasal inflammatory diseases. With the modernization of urban life, automobile exhaust, decorative materials and food additives, etc., are the main causes of rhinitis (including allergic rhinitis, chronic rhinitis, chronic sinusitis, etc.). In recent years, the incidence of allergic rhinitis has a global increase trend, which is regarded as "the epidemic of the 21st century". Its global average incidence is 10% to 25%. Although not life-threatening, nasal symptoms, eye symptoms, and related organ symptoms (bronchial asthma, otitis media, etc.) caused by allergic rhinitis can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K36/539A61K47/26A61P11/02A61P37/08
CPCA61K9/0043A61K36/17A61K36/232A61K36/28A61K36/484A61K36/534A61K36/539A61K47/26A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 顾政一刘燕毛艳贺金华陈振东肖女
Owner XINJIANG INST OF MATERIA MEDICA
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