34 results about "S-Nitrosoglutathione" patented technology

The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.

The invention provides stable S-nitrosothiol, such as S-nitrosoglutathione, formulations for long term storage and in vivo delivery of S-nitrosothiols. The invention provides stable aerosol formulations comprising S-nitrosothiol, such as S-nitrosoglutathione, and methods of treating patients in need of S-nitrosothiol, such as S-nitrosoglutathione, and/or nitric oxide treatment.

The invention relates to pharmaceutical compositions comprising S-nitrosoglutathione and one or more polysaccharide-type polimer(s) together with one or more pharmaceutically accepted polymer(s) and additive(s). The invention is based on the discovery that polysaccharide-type polymers (such as chitosan) are capable of stabilizing the otherwise highly labile GSNO.

The invention relates to the technical field of biomedical materials, and provides a nitride oxide nanocomposite hydrogel. The nitride oxide nanocomposite hydrogel is constituted by S-nitrosoglutathione (GSNO) loaded Eudragit RS PO nano suspension and a gel matrix in a mixed mode, the gel matrix is prepared from sodium alginate, a calcium chloride solution and glycerin, and mixed gel contains nanoparticles with Eudragit RS PO loaded with GSNO. The invention further provides a preparation method of the nitride oxide nanocomposite hydrogel and application of the nitride oxide nanocomposite hydrogel in the field of the biomedical materials. According to the nitride oxide nanocomposite hydrogel, aiming at two critical periods of the inflammation period and the proliferation period in skin wound healing, the nitric oxide nanocomposite hydrogel is constructed by taking the sodium alginate as a matrix phase and taking the nanoparticles with the Eudragit RS PO loaded with nitric oxide donor GSNO as a dispersion phase, nitric oxide is released at the wound part, thus generating of angiogenesis and generating of fibroblast in the inflammation period of wound repair are promoted, and generating of collagenous fibers in the proliferation period is promoted, so that the purpose of effectively promoting skin wound healing is achieved.

The present invention is directed to novel dihydropyridin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors and/or Neurokinin-3 (NK3) receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of making and using the same.

The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.

The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.

This invention provides a method of sterilising an S-nitrosothiol, for example S-nitrosoglutathione, without reduction of purity by more than about 5.0% through degradation. The invention allows sterile S-nitrosothiol or a sterile pharmaceutical pre-composition comprising S-nitrosothiol, wherein the S-nitrosothiol is in dry solid form, to be produced. The sterile pharmaceutical pre-composition is mixed with one or more diluents, excipients, carriers, additional active agents, or any combination thereof, for example sterile saline, to prepare a pharmaceutical composition of S-nitrosothiol for use.

The invention discloses a shelf fresh-keeping combined treatment method for semen trigonellae fruits. Beta-aminobutyric acid spray coating before harvesting and S-nitrosoglutathione fumigation treatment after harvesting are carried out, and enclosing packaging technology with certain air permeability and gamma irradiation technology are combined to realize the purpose, so that the shelf life of semen trigonellae fruits at room temperature or 4-5DEG C can be significantly prolonged, and the semen trigonellae fruits also can maintain good hardness, flavor and nutritional quality.