Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for stabilization of s-nitrosoglutathione and composition prepared by the same

一种组合物、聚合物的技术，应用在药物组合、药物输送、医药配方等方向，能够解决没有效果或代谢等问题

Inactive Publication Date: 2011-02-09
PHARMAGENIX
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These cyclic compounds are not currently used in clinical practice, so there is no information on their effects or metabolism

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for stabilization of s-nitrosoglutathione and composition prepared by the same
  • Method for stabilization of s-nitrosoglutathione and composition prepared by the same
  • Method for stabilization of s-nitrosoglutathione and composition prepared by the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] definition:

[0032] GSNO

[0033] GSNO (S-nitrosoglutathione) is an endogenous compound that plays an important role in NO metabolism. Reduced glutathione, a free radical-trapping tripeptide found in cells and certain cellular components such as mitochondria, is capable of reacting with NO, which binds to the sulfur atom of the tyrosine side chain at the center of the molecule to form a nitrosoglutamate Glutathione. During GSNO metabolism, this bond dissociates and NO is released, so GSNO is not only a free radical capture molecule, but also a NO transporter molecule. A large amount of GSNO is not only found in the cell, but also exists in the extracellular space, such as in the blood, so its physiological function is to help transport NO and maintain a constant blood concentration of NO.

[0034] Several reaction schemes for the synthesis of GSNO are known. According to known reactions, sodium nitrite followed by acetone is added to cold acidic glutathione aqueo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to pharmaceutical compositions having alkaline pH comprising S-nitrosoglutathione (GSNO) as active ingredient together with usual additives, optionally with one or more polysaccharide-type polymer(s). Another subject of the invention is a method for stabilizing a solution or non-solid composition containing GSNO wherein the pH of the solution or composition is adjusted to analkaline value.

Description

field of invention [0001] The present invention mainly relates to a pharmaceutical composition with an alkaline pH comprising S-nitrosoglutathione (GSNO) as an active ingredient together with usual additives, and optionally one or more polysaccharide polymers . The present invention is based on the surprising discovery that GSNO produced in high yields under acidic conditions is more stable than under basic conditions, especially in the presence of stabilizing polymers. technical background [0002] Vasoconstriction that develops in microcirculatory disturbances with increased susceptibility to thrombosis and accumulation of free radicals released in certain metabolic problems can cause complex tissue damage that leads to decreased wound healing and, in some cases, chronic ulcers [Greenman et al., 2005, Lancet, 366, 1711-7; Sigaudo-Roussel et al., 2004, Diabetes, 53, 1564-9; Veves et al., 1998, Diabetes, 47, 457-63; Hile and Veves, 2003, Curr. Diab. Rep., 3, 446-51; Nikolo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00
CPCA61K9/0014A61K9/06A61P3/10A61P9/08A61P11/06A61P17/00A61P17/02A61P21/00A61P25/00A61P25/02
Inventor Z·洛曹I·霍尔尼亚克
Owner PHARMAGENIX
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com