Novel S-nitrosoglutathione reductase inhibitors
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- NIVALIS THERAPEUTICS
- Publication Date
- 2013-01-09
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
Technical field
[0001] The present invention relates to new compounds, pharmaceutical compositions containing such compounds, and methods for preparing and using the compounds. These compounds can be used as inhibitors of S-nitrosoglutathione reductase (GSNOR). Background technique
[0002] The compound nitric oxide is a gas with the molecular formula NO. NO is one of the few known gas signal molecules in biological systems and plays an important role in the control of various biological events. For example, the endothelium uses NO to transmit signals around the smooth muscles of the arteriole walls to relax, causing vasodilation and increasing blood flow to hypoxic tissues. NO is also involved in the regulation of smooth muscle proliferation, platelet function and neurotransmission, and plays a role in host defense. Although NO is highly reactive and has a lifetime of several seconds, it can not only diffuse freely across the membrane, but also bind to many molecular targets....