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S-nitrosothiol-mediated hyperbranched polyesters

A polyester and alkyl technology, applied in the field of hyperbranched polyester mediated by S-nitrosothiol, can solve the problems of unclear development and use of hyperbranched polyester

Active Publication Date: 2019-06-25
THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Despite interest in biomedical applications of these polymers due to their ease of synthesis, biodegradability, and solubility, the development and use of hyperbranched polyesters for NO release applications remains unclear

Method used

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  • S-nitrosothiol-mediated hyperbranched polyesters
  • S-nitrosothiol-mediated hyperbranched polyesters
  • S-nitrosothiol-mediated hyperbranched polyesters

Examples

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Embodiment Construction

[0030]The present invention may be understood more readily by reference to the following detailed description of the invention and the Examples included therein.

[0031] Before the compounds, compositions, articles, systems, devices and / or methods of the present invention are disclosed and described, it is to be understood that they are not limited to particular synthetic methods unless otherwise indicated, or that they are not limited to particular reagents unless otherwise indicated, and of course , they can vary. It is also to be understood that terminology used herein is for the purpose of describing particular aspects only and is not intended to be limiting. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, exemplary methods and materials are now described.

[0032] Although aspects of the present invention may be described and claimed in a particular statutory class, such ...

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Abstract

The invention generally relates to compositions comprising degradable polymers and methods of making degradable polymers. Specifically, the disclosed degradable polymers comprise a biodegradable polymer backbone, a nitric oxide linker moiety, and a nitric oxide molecule. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limitingof the present invention.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 62 / 405,655, filed October 07, 2016, which is hereby incorporated by reference in its entirety. [0003] Statement Regarding Federally Funded Research [0004] This invention was made with government support under Grant No. DE025207 awarded by the National Institutes of Health (NIH). The government has certain rights in this invention. Background technique [0005] Nitric oxide (NO) is a mediator of angiogenesis (J.P. Cooke, Atherosclerosis Supplement, 2003,4,53-600), blood pressure regulation (D.D.Rees, R.M.Palmer and S.Moncada, Proc.Natl.Acad.Sci, 1989, 86, 3375-3378), wound healing (J.-d.Luo and A.F.Chen, Acta Pharmacol. Sin., 2005, 26, 259-264; M.R.Schaffer, U.Tantry, S.S.Gross, H.L.Wasserkrug and A.Barbul, J. .Surg.Res., 1996,63,237-240) and immune response (C.Bogdan, Nat.Immunol, 2001, 2,907-916; J.MacMicking, Q.-w.Xie and C.Nathan, Annu.Rev.Im...

Claims

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Application Information

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IPC IPC(8): C08K3/28C08G77/26C07F7/10
CPCA61K33/00A61L27/34A61L27/54A61L27/58A61L29/085A61L29/148A61L29/16A61L31/10A61L31/148A61L31/16A61L2300/114A61K47/593C08G63/6852C08G63/6882C08G63/912C08G83/006C08L67/04C08G63/916C08G2230/00Y02P20/55
Inventor M·舍恩费希杨磊吕源
Owner THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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