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Improvements relating to skin dressings

A skin and thiol technology, applied in skin diseases, medical science, flake delivery, etc.

Inactive Publication Date: 2010-11-03
INSENSE LIMITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While it is possible to ensure this rapid production of nitrosothiols by simply adjusting the pH, the required acidity may prevent the applicability of such formulations (e.g. when applied to intact or damaged skin)

Method used

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  • Improvements relating to skin dressings
  • Improvements relating to skin dressings
  • Improvements relating to skin dressings

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0093] Example 1: Cu 2+ Effect on the rate of nitrosylation of 1-thioglycerol

[0094] This example shows the cation of divalent copper at pH 4.0 ( figure 1 ), pH 4.5 ( figure 2 ), and pH 5.0 ( image 3 ) on the formation rate of nitrosothiols. The rate of nitrosylation, followed by measuring the absorbance of the samples at 338 nm, increased considerably in the presence of cupric cations at concentrations ranging from 10 μM to 100 μM.

example 2

[0095] Example 2: Zn + Effect on the rate of nitrosylation of 1-thioglycerol

[0096] This example demonstrates that the zinc cation is at pH 4.0 ( Figure 4 ) on the formation rate of nitrosothiols. The rate of nitrosylation, followed by measuring the absorbance of these samples at 338 nm, increased in the presence of 100 μM zinc cation. The increase in nitrosylation rate was more pronounced in the presence of cations of 250 μM zinc.

example 3

[0097] Example 3: Fe 2+ Effect on the rate of nitrosylation of 1-thioglycerol

[0098] This example demonstrates that iron cations at pH 4.0 ( Figure 5 ) and pH 4.5 ( Figure 6 ) on the formation rate of nitrosothiols. Due to interference from these iron species, the rate of nitrosylation could not be followed by measuring the absorbance of these samples at 338 nm. Instead, the production of S-nitroso-1-thioglycerol was followed by the Griess method (Cook et al. Analytical Biochemistry, 238, 150-158, 1996). The rate of nitrosylation was found to increase in the presence of 100 μM and 250 μM iron cations.

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Abstract

Improvements relating to skin dressing A skin dressing adapted, on activation, to generate one or more S-nitrosothiols by reaction between a thiol and a nitrite salt in the dressing, the skin dressing comprising a source of Cu2+, Zn2+ and / or Fe2+ ions for delivery of nitric oxide to a body site is provided.

Description

technical field [0001] The present invention relates to skin dressings for application to a part of the human or animal body for the treatment of skin (for therapeutic or cosmetic purposes), and in particular (but not exclusively) to the treatment of deficient skin, especially Wound dressings for skin lesions, which means any interruption of the skin surface, whether caused by injury or disease, including skin ulcers, burns, cuts, punctures, lacerations, blunt trauma, acne lesions, boils, wait. The term "dermal dressing" encompasses dressings, such as patches, plasters, bandages, gauze, etc., used in conjunction with the transdermal delivery of agents. The term also includes materials in amorphous or liquid form. The term generally covers dressings for application to body surfaces, including internal and external tissues, especially the skin (including the scalp). The present invention is based on the beneficial properties of nitric oxide (NO). Background of the invention...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/24
CPCA61L26/0004A61L15/18A61K9/70A61L15/44A61L2300/114A61L26/0066A61P17/02
Inventor J·耶泽克L·P·沃森
Owner INSENSE LIMITED
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