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Waterproof, breathable, high-elastic and self-repairing double-layer nanofiber membrane for skin dressing and preparation method of nanofiber membrane

A nanofiber membrane, waterproof and breathable technology, used in medical science, non-woven fabrics, absorbent pads, etc., can solve problems such as difficulty in meeting different healing needs, and achieve the effect of improving healing performance, good comfort, and superior resilience.

Active Publication Date: 2020-08-28
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the double-layer nanofiber dressing in the prior art cannot integrate high elasticity, waterproof and breathable and self-repairing properties, and it is difficult to meet the different healing needs of various types of wounds, and to provide a waterproof and breathable skin dressing. High elastic self-healing double-layer nanofiber membrane and its preparation method

Method used

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  • Waterproof, breathable, high-elastic and self-repairing double-layer nanofiber membrane for skin dressing and preparation method of nanofiber membrane
  • Waterproof, breathable, high-elastic and self-repairing double-layer nanofiber membrane for skin dressing and preparation method of nanofiber membrane
  • Waterproof, breathable, high-elastic and self-repairing double-layer nanofiber membrane for skin dressing and preparation method of nanofiber membrane

Examples

Experimental program
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Effect test

Embodiment 1

[0050] A method for preparing a waterproof, breathable, highly elastic, self-repairing double-layer nanofiber membrane for skin dressing, the steps are as follows:

[0051] (1) Prepare water-based polyurethane solution with absolute ethanol, add alcohol-soluble hydrophobic agent (polymethylhydrogensiloxane emulsion), environment-friendly crosslinking agent (epoxysilane crosslinking agent) and functional drug (diclofenac sodium), Stir evenly to prepare precursor spinning solution Ⅰ; the mass fraction of water-based polyurethane in precursor spinning solution Ⅰ is 5%, and the addition amount of alcohol-soluble hydrophobic agent and environment-friendly crosslinking agent is 10wt% and 2wt of water-based polyurethane respectively %;

[0052] (2) Put the precursor spinning solution I prepared in step (1) into a syringe, spin with an electrospinning device, and receive it through the receiving substrate (glossy paper) to prepare a hydrophobic fiber membrane with a thickness of 0.1 μ...

Embodiment 2

[0060] A method for preparing a waterproof, breathable, highly elastic, self-repairing double-layer nanofiber membrane for skin dressing, the steps are as follows:

[0061] (1) Prepare water-based acrylic resin solution with isopropanol, add alcohol-soluble hydrophobic agent (polymethylhydrogensiloxane emulsion), environment-friendly cross-linking agent (organosilane cross-linking agent) and functional drug (warfarin) , and stir evenly to prepare the precursor spinning solution Ⅰ; the mass fraction of the water-based acrylic resin in the precursor spinning solution Ⅰ is 12%, and the addition amount of the alcohol-soluble hydrophobic agent and the environment-friendly cross-linking agent is 5wt of the water-based acrylic resin respectively % and 1wt%;

[0062] (2) Put the precursor spinning solution I prepared in step (1) in a syringe, spin with an electrospinning device, and receive it through the receiving substrate (aluminum foil) to prepare a hydrophobic fiber membrane with...

Embodiment 3

[0070] A method for preparing a waterproof, breathable, highly elastic, self-repairing double-layer nanofiber membrane for skin dressing, the steps are as follows:

[0071] (1) Prepare polyvinylpyrrolidone solution with absolute ethanol, add alcohol-soluble hydrophobic agent (polydimethylsiloxane emulsion), environment-friendly crosslinking agent (blocked isocyanate crosslinking agent) and functional drug (aspirin), Stir evenly to prepare precursor spinning solution I; the mass fraction of polyvinylpyrrolidone in precursor spinning solution I is 10%, and the addition amount of alcohol-soluble hydrophobic agent and environmentally friendly crosslinking agent is respectively 10wt% of polyvinylpyrrolidone and 2 wt%;

[0072] (2) Put the precursor spinning solution I prepared in step (1) in a syringe, spin it with an electrospinning device, and receive it through the receiving substrate (glossy paper) to prepare a hydrophobic fiber membrane with a thickness of 0.3 μm ; Among them...

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Abstract

The invention relates to a waterproof, breathable, high-elastic and self-repairing double-layer nanofiber membrane for skin dressing and a preparation method of the nanofiber membrane. The preparationmethod comprises the following steps: firstly, carrying out electrostatic spinning on a precursor spinning solution I consisting of a synthetic polymer solution, an alcohol-soluble hydrophobic agent,an environment-friendly cross-linking agent and a functional drug to prepare a hydrophobic fiber membrane; then carrying out electrostatic spinning on a precursor spinning solution II consisting of anatural polymer solution, a catechol-based molecular solution and anhydrous ferric trichloride powder, and receiving the obtained material on the hydrophobic fiber membrane to prepare a composite fiber membrane; and finally carrying out aftertreatment on the composite fiber membrane to obtain the nanofiber membrane. The water pressure resistance of the prepared double-layer nanofiber membrane is5-50kPa, the air permeability is 5-15kg / m<2> / d, the elastic modulus is 5-15MPa, the tensile strength and elongation at break of a self-repaired fiber membrane are 50-90% of an initial fiber membrane,and the adhesion and comfort of a wound surface can be guaranteed while the healing promoting capability of the dressing is improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a waterproof, breathable, highly elastic, self-repairing double-layer nanofiber membrane for skin dressing and a preparation method thereof. Background technique [0002] According to statistics, tens of millions of people in my country have skin trauma caused by natural disasters or accidents every year. Traditional dressings have limited absorption capacity, need to be replaced frequently, and easily lead to severe dehydration of the wound surface, which is not conducive to rapid and effective wound healing. Compared with traditional dressings that have many disadvantages, high-end dressings based on moist wound healing theory are widely accepted as an effective way to promote wound healing. However, my country is relatively weak in the research and development and production of high-end dressings, and there is an urgent need to develop high-end dressings that are e...

Claims

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Application Information

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IPC IPC(8): A61L15/20A61L15/24A61L15/26A61L15/28A61L15/32A61L15/42A61L15/44D04H1/728
CPCA61L15/20A61L15/24A61L15/26A61L15/28A61L15/32A61L15/42A61L15/425A61L15/44A61L2300/21A61L2300/216A61L2300/41D04H1/728C08L89/06C08L5/08C08L75/04C08L33/02
Inventor 李晓然郑玉琦周文帕维尔·纳基尔斯基基亚拉·里诺迪菲利波·皮耶里尼丁彬俞建勇
Owner DONGHUA UNIV
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