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A kind of composite polypropylene mesh and preparation method thereof

A technology for compounding polypropylene and polypropylene mesh, which is used in medical science, prosthesis, etc., can solve the problems of easy separation, fast degradation of chitosan, and incompatibility between chitosan film and polypropylene mesh. , to achieve the effect of not easy to degrade and induce fascia reconstruction

Active Publication Date: 2017-06-16
海南德拉米克投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation rate of chitosan in the above-mentioned polypropylene mesh is fast, and the combination of the chitosan hanging film and the polypropylene mesh is not tight and easy to separate, which is not conducive to clinical use.

Method used

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  • A kind of composite polypropylene mesh and preparation method thereof
  • A kind of composite polypropylene mesh and preparation method thereof
  • A kind of composite polypropylene mesh and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0028] The present invention also provides a kind of preparation method of composite polypropylene mesh, comprises the following steps:

[0029] A) the polypropylene mesh is placed in the dopamine aqueous solution to react to obtain the polydopamine-polypropylene mesh;

[0030] B) The polydopamine-polypropylene mesh is placed in a fibroblast growth factor solution for reaction, and the polypropylene mesh is compounded.

[0031] Before the polypropylene mesh is reacted with the dopamine aqueous solution, the present invention first pretreats the polypropylene mesh, that is, the polypropylene mesh is placed in an ethanol solution with a volume fraction of 75% to 95% for surface treatment , to remove impurities, and can achieve the purpose of sterilization.

[0032] In the invention, the pretreated polypropylene mesh is placed in the dopamine aqueous solution for reaction to obtain the polydopamine-polypropylene mesh.

[0033] The dopamine aqueous solution of the present invent...

Embodiment 1

[0045] The polypropylene mesh is placed in an ethanol solution with a volume fraction of 75% for surface treatment to obtain a pretreated polypropylene mesh.

[0046] Preparation of dopamine solution: 10 mM Tris-HCl buffer solution was used to prepare a dopamine solution with a concentration of 2 mg / ml and a pH value of 8.5. The dopamine aqueous solution is sterilized by filtering through a 0.22 μm filter membrane.

[0047] Soak the pretreated polypropylene mesh in dopamine solution, react at 25° C. for 12 hours, and rinse with deionized water for 5 times to obtain a polydopamine-polypropylene mesh.

[0048] Take out the above-mentioned polydopamine-polypropylene mesh, soak it in the fibroblast growth factor buffer solution with a concentration of 10 μg / ml and a pH value of 8.5, the buffer solution is 10 mM Tris-HCl buffer solution, at 25 ° C After reacting for 12 hours, take it out, rinse it with deionized water for 5 times, and finally dry it with argon flow to obtain a com...

Embodiment 2

[0106] The polypropylene mesh is placed in an ethanol solution with a volume fraction of 75% for surface treatment to obtain a pretreated polypropylene mesh.

[0107] Preparation of dopamine solution: use 10 mM Tris-HCl buffer to prepare a dopamine solution with a concentration of 1 mg / ml and a pH value of 9.0. The dopamine aqueous solution is sterilized by filtering through a 0.22 μm filter membrane.

[0108] Soak the pretreated polypropylene mesh in dopamine solution, react at 25° C. for 12 hours, and rinse with deionized water for 5 times to obtain a polydopamine-polypropylene mesh.

[0109] Take out the above-mentioned polydopamine-polypropylene mesh, and soak it in a fibroblast growth factor buffer solution with a concentration of 15 μg / ml and a pH value of 9.0. After reacting for 12 hours, take it out, rinse it with deionized water for 5 times, and finally dry it with argon flow to obtain a composite polypropylene mesh.

[0110] The properties of polypropylene mesh, po...

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Abstract

The invention provides a composite polypropylene mesh, which is formed by bonding the polypropylene mesh and fibroblast growth factor through polydopamine. In the present invention, under the premise of not changing the mechanical strength and surface structure of the original polypropylene mesh, after grafting polydopamine on the surface of the polypropylene mesh, and then grafting fibroblast growth factor on the surface of the polydopamine, no composite The phenomenon of mesh separation. At the same time, fibroblast growth factor is not easily degraded in vivo and can induce fibroblast growth, thereby inducing fascial reconstruction.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and in particular relates to a composite polypropylene mesh and a preparation method thereof. Background technique [0002] Female pelvic floor dysfunction is a common disease and frequently-occurring disease in middle-aged and elderly women over 50 years old, which seriously affects the life and health of middle-aged and elderly women. The current treatment method is to use some mesh belts or sheets of medical polypropylene synthetic materials to reconstruct the pelvic floor function through surgery. [0003] The pelvic floor functional reconstruction polypropylene mesh designed by Johnson & Johnson, with a dry weight of about 50g / m 2 , the researchers improved the weaving process of the mesh, making each fiber of the mesh thinner, larger in aperture, and lighter in weight, in order to reduce side effects. Although the weaving process has been improved, the pure polypropylene mesh s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/18
Inventor 崔文国陈信良
Owner 海南德拉米克投资有限公司
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