Cellulose gelatin coating-based rotator cuff patch and preparation method thereof

A technology of cellulose and patch, applied in the field of making patch and rotator cuff patch, can solve problems such as foreign body reaction and local inflammation, and achieve good biocompatibility

Pending Publication Date: 2022-04-22
福州市第二医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Artificial grafts have advantages in terms of biomechanics, but there are problems such as foreign body reactions or local inflammation

Method used

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  • Cellulose gelatin coating-based rotator cuff patch and preparation method thereof
  • Cellulose gelatin coating-based rotator cuff patch and preparation method thereof
  • Cellulose gelatin coating-based rotator cuff patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of mesh

[0041] The preparation method of cellulose electrospinning film comprises the following steps: 1.5g of cellulose acetate is added to a mixed solvent composed of 6mL N, N-dimethylacetamide (DMAc) and 4mL acetone, stirred for about 6h to form a uniform and transparent slurry. Under the condition of spinning rate of 0.4mL / h and spinning voltage of 10kV, the slurry electrospinning is formed into a film. The membrane was then immersed in LiOH aqueous solution (0.05mol / L) for 12 h, washed with deionized water, and dried in a vacuum oven at 70 °C for 12 h.

[0042] At 50 ~60 °C, dissolve astragalus extract in 5wt% gelatin solution and stir well to give Gel-astragalus extract solution, the concentration of astragalus extract is 5mg / ml. The pretreated cellulose electrospinning membrane was immersed in Gel-Astragalus extract solution, sonicated for 5min, and the cellulose electrospinning membrane was slowly lifted with forceps at a speed of 1 mm / s and ...

Embodiment 2

[0045] Example 2 Performance test

[0046] Animal experiment grouping: a. cellulose membrane group; b. cellulose gelatin coating group.

[0047] Weaving of the mesh: The mesh is sewn at both ends so that it is used to stitch the rotator cuff stumps and the humerus end to fix. The size of the patch after weaving is 10 mm long, 4 mm wide and 1 mm thick, which is suitable for the suturing model of the tendon under the rabbit gang. The sutured patch was biomechanically tested to meet the maximum needs of rabbit inferior muscle tears of about 130 N.

[0048] (1) 2.5-3.5kg New Zealand white rabbit, anesthetized shoulder joint skin, about 4cm parallel incision above the inferior tendon, layer by layer blunt separation, exposing the inferior tendon. The inferior muscle is excised close to the humerus stop point and the stump and bone surface are rested.

[0049] (2) Make 2 1mm bone passages at the humerus stop point, cross the stump of the inferior muscle, and stitch the suture back to th...

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PUM

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Abstract

A rotator cuff patch based on a cellulose gelatin coating comprises a rotator cuff patch body, a cellulose electrostatic spinning membrane serving as a patch substrate layer, gelatin containing chondroitin sulfate serving as a load anti-inflammatory drug layer and gelatin containing astragalus extract serving as a load healing promoting drug layer, and the rotator cuff patch can inhibit inflammatory reaction in the early stage, promote tissue regeneration in the repair period and promote healing. The effect of promoting graft integration is achieved.

Description

Technical field [0001] The present invention belongs to the field of tissue repair, in particular to a rotator cuff patch based on a cellulose gelatin coating, for the repair of the rotator cuff, inhibit the occurrence and development of inflammation, facilitate further play a pro-healing effect, and a method of preparing a patch. Background [0002] Rotator cuff tears can cause joint pain, weakened function, stiffness and limited range of motion, and place a huge economic burden on society. A huge rotator cuff tear is a rotator cuff injury with a torn opening of > 5 cm or involving ≥ 2 tendons, and is currently treated mainly for surgical repair. Some patients have greatly improved shoulder function after surgery, but the re-tear rate is high, reaching 15% to 94%. The cause of the relapse is related to factors such as tear size, blood supply, fat infiltration, age, smoking, and muscle atrophy. Studies have shown that tear size is more relevant to re-tearing, because tension ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/22A61L27/36A61L27/54A61L27/58
CPCA61L27/20A61L27/222A61L27/3637A61L27/54A61L27/58A61L2300/232A61L2300/30A61L2300/41A61L2300/416A61L2300/426A61L2430/34C08L1/02C08L5/08C08L89/00
Inventor 张韬刘楠楠吴冬枝何文慧
Owner 福州市第二医院
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