Chemical exchange characteristic quantification method and equipment

Abstract

The invention is suitable for the field of biomedical engineering, and provides a chemical exchange characteristic quantification method and chemical exchange characteristic quantification equipment.The chemical exchange characteristic quantification method comprises the steps of: acquiring signal intensity measured values of CEST signals of various CEST contrast agents; respectively calculatingcorresponding signal intensity theoretical values under the same saturation pulse parameter and resonance frequency as the signal intensity measured values based on a theoretical chemical exchange characteristic quantitative range of each CEST contrast agent; and regarding theoretical chemical exchange characteristic quantification corresponding to the theoretical value with the highest matching degree as a chemical exchange characteristic quantification result of the CEST contrast agents. According to the chemical exchange characteristic quantification method and the chemical exchange characteristic quantification equipment, the chemical exchange characteristic quantification process does not need to select a reference signal, thus is not susceptible to other chemical exchange effects, the theoretical chemical exchange characteristic quantification corresponding to the matching result can represent the actual chemical exchange specific quantity more precisely, and the precision of thechemical exchange specific quantity is effectively improved.

Description

technical field [0001] This application relates to the field of biomedical engineering, in particular to a method and equipment for chemical exchange of specific quantities. Background technique [0002] Chemical Exchange Saturation Transfer (CEST) imaging is a magnetic resonance molecular imaging method, based on the chemical exchange between exchangeable protons and water molecules in endogenous or exogenous CEST contrast agents, it can non-invasively obtain biological Micro-level information such as tissue energy metabolism, acid-base environment, and contrast agent content has important research value and application potential in the identification, diagnosis, and evaluation of diseases. CEST contrast agents include the body's own metabolites and exogenous contrast agents; among them, representative endogenous CEST contrast agents include protein, creatine, glucose, etc., which can reflect cell composition, acid-base environment, energy metabolism and intake, etc. IMPOR...

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Problems solved by technology

[0004] The embodiment of the present application provides a method and equipment for quantifying chemical exchange characteristics, which can solve the problem of low quantitative accuracy of chemical exchange characteristics of CEST contrast agents in the prior art

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