Rapid chemical exchange saturation transfer imaging method and system

A technology of chemical exchange and transfer imaging, which is used in medical science, diagnosis, measurement of magnetic variables, etc. It can solve the problems of long CEST imaging time, and achieve the effect of realizing self-adaptation, improving imaging speed and ensuring reconstruction quality.

Active Publication Date: 2016-07-13
SHENZHEN INST OF ADVANCED TECH
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Problems solved by technology

[0007] This application provides a fast chemical exchange saturation transfer imaging method and system, which solves the problem of long imaging time of CEST

Method used

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  • Rapid chemical exchange saturation transfer imaging method and system
  • Rapid chemical exchange saturation transfer imaging method and system
  • Rapid chemical exchange saturation transfer imaging method and system

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Experimental program
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Embodiment 1

[0030] Please refer to figure 1 , the present embodiment provides a fast chemical exchange saturation transfer imaging method, comprising the following steps:

[0031] Step 1.1: Collect multiple sets of fully collected CEST data as test data. .

[0032] Step 1.2: Calculate the average signal intensity of images at different polarization frequencies based on the collected test data. In this application, the average value of the image grayscale signal is taken as the average signal intensity of the image.

[0033] Before collecting the CEST imaging data, the signal distribution is not known, so the test data should be used to pre-estimate the distribution of the signal strength to determine the reduction rate used in the following steps, and then collect according to the selected reduction rate .

[0034] Step 1.3: Determine the relationship between the average signal strength of the image and the preset signal strength threshold T. When the relationship meets the preset con...

Embodiment 2

[0078] Please refer to figure 2 , the present embodiment provides a fast chemical exchange saturation transfer imaging system, including a test data acquisition module 101, an average signal intensity acquisition module 102, a reduction rate determination module 103, a sampling template calculation module 104, a CEST imaging data acquisition module 105 and Image reconstruction module 106 .

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Abstract

The invention discloses a rapid chemical exchange saturation transfer imaging method and system, and the method determines that a current image employs a first downsampling rate or a second downsampling rate through judging the relation between the mean signal intensity of the image and a preset signal intensity threshold value; The method solves a problem that a low signal to noise ratio image is difficult to achieve a better reconstruction result because all CEST images employ the same downsampling rate, achieves the adaptivity of a CEST imaging undersampling mode, improves the CEST imaging speed, and guarantees the reconstruction quality of an CEST image.

Description

technical field [0001] The present application relates to the technical field of magnetic resonance imaging, in particular to a fast chemical exchange saturation transfer imaging method and system. Background technique [0002] Magnetic resonance chemical exchange saturation transfer (Chemical Exchange Saturation Transfer, CEST) imaging is a new magnetic resonance contrast imaging mechanism. This imaging method is sensitive to the chemical exchange and chemical kinetics of dilute macromolecules. potential for tracking tumor cells, bacterial / viral infection, pH and temperature changes, etc. In recent years, CEST imaging has been increasingly used in the research of in vivo diseases such as tumors, acute stroke and kidney injury, and has become a new method of magnetic resonance molecular imaging. [0003] Chemical exchange saturation transfer imaging is a new endogenous molecular imaging method, which uses a new contrast mechanism to selectively saturate exchangeable protons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/485A61B5/055
CPCA61B5/055G01R33/485
Inventor 梁栋朱燕杰刘新郑海荣
Owner SHENZHEN INST OF ADVANCED TECH
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