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CEST (Chemical Exchange Saturation Transfer) image reconstruction method and device based on variable acceleration sensitivity encoding

A sensitivity coding and image reconstruction technology, applied in the field of magnetic resonance imaging, can solve the problem of data acquisition speed prone to artifacts

Active Publication Date: 2019-06-04
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to solve the technical problems of artifacts and slow data acquisition speed in the acceleration process of the traditional SENSE method, and provide a CEST image reconstruction method based on variable acceleration sensitivity coding

Method used

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  • CEST (Chemical Exchange Saturation Transfer) image reconstruction method and device based on variable acceleration sensitivity encoding
  • CEST (Chemical Exchange Saturation Transfer) image reconstruction method and device based on variable acceleration sensitivity encoding
  • CEST (Chemical Exchange Saturation Transfer) image reconstruction method and device based on variable acceleration sensitivity encoding

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Experimental program
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Effect test

Embodiment

[0100] 1. MRI experiment

[0101] The brains of 7 healthy volunteers and 15 brain tumor patients were scanned with a 3 Tesla Philips Achieva scanner (Best, Netherlands) with a 32-channel head coil.

[0102] First, a SENSE reference scan (flip angle FA = 1 0 ; Repetition time (TR) = 4ms; Echo time (TE) = 0.8ms; Field of view (FOV) = 450×300×300mm 3 ;Resolution=4.7×4.7×3mm 3 ; average times = 3; duration = 39s). Structural images include double-echo T2-weighted fast spin-echo sequences (TR=2.8s; TE=10ms or 80ms; FOV=212×190×131mm 3 ;Resolution=1.1×1.1×2.2mm 3 ; duration = 2.4min), FLAIR (water inhibition inversion recovery) sequence (TR = 11s; TE = 120ms; FOV = 212 × 189 × 132mm 3 ;Resolution=0.8×1.1×2.2mm 3 ; inversion time TI=2.8s; duration=3.9min) and T1-weighted MPRAGE (44) (pre-magnetization fast gradient echo sequence) sequences (TR=8ms; TE=3.7ms; FOV=212×172×165mm 3 ;Resolution=1×1×1.1mm 3 ; TI=0.8s; Duration=3.4min). For some patients with brain tumors, MRI with...

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Abstract

The invention discloses a chemical exchange saturation transfer (CEST) imaging method and device based on a variable acceleration sensitivity encoding method, and belongs to the field of magnetic resonance imaging. In the method, Fourier transform is carried out on K-space data formed by a measured object in CEST imaging to obtain image space folding data of each voxel, wherein the image space folding data includes at least one undersampled frame accurate image with the acceleration factor R1 being greater than or equal to 1 and a plurality of other to-be-reconstructed undersampled frame images with the acceleration factor being not less than R1; and then image reconstruction is carried out on the to-be-reconstructed undersampled frame images with the acceleration factor being R2. The sensitivity map of the traditional SENSE method can be modified by using undersampled frames. The reconstruction error of the method is basically the same as that of the traditional SNESE method which applies a low acceleration factor in a CEST source image, but the speed of the method is twice or more the speed of the traditional SENSE method. Since it is unnecessary to adopt fully sampled frames, the method is particularly applicable to three-dimensional (3D) CEST imaging.

Description

technical field [0001] The invention belongs to the field of magnetic resonance imaging, in particular to a chemical exchange saturation transfer imaging method based on a variable acceleration sensitivity coding method. Background technique [0002] Chemical exchange saturation transfer (CEST) imaging exploits the special phenomenon of protons in various solute pools exchanging or interacting with those in free water pools and disrupts this polarization transfer process with selective radio frequency (RF) pulses. In the CEST method, the repeated saturation transfer process can accumulate and amplify the MRI signal from the solute pool, so the CEST method can improve the detection sensitivity of low-concentration metabolites in vivo. Various biomolecules can be detected by the branch technology of chemical exchange saturation transfer (CEST) technology, such as APT technology can detect polypeptide, glycogen chemical exchange saturation transfer technology can detect glycoge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/54A61B5/055G06T11/00
Inventor 张祎刘瑞斌吴丹
Owner ZHEJIANG UNIV
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