89 results about "Macromolecular Complexes" patented technology

The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of inter-macromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other and are then either dried into membranes or sponges or are used as fluids or microspheres. Bioresorbable, bioadhesive, antiadhesion compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The antiadhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes and gels can be varied as needed by carefully adjusting the pH and/or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by conditioning the membranes prior to surgical use. Multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Membranes and gels can be used concurrently. Antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.

The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other, and are then either dried into membranes or sponges, or are used as fluids or microspheres. Bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes and gels can be varied as needed by carefully adjusting the pH and/or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by conditioning the membranes prior to surgical use. Multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Membranes and gels can be used concurrently. Antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.

A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure is described. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.

A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit (50) through a subject's heart during a surgical procedure in which the substance is prevented from being delivered to the subject's other organs.

Methods and compositions for treating or preventing diarrhea are disclosed. The methods comprise administering to an individual a therapeutically effective amount of an LPA₂ receptor agonist for treating or preventing diarrhea. Also disclosed is a method of inhibiting CFTR activation by administering at least one LPA₂ receptor agonist in an amount effective to inhibit formation of a macromolecular complex between the LPA₂ receptor, CFTR, and a Na⁺/H⁺ exchange regulatory factor-2 (NHERF-2).

An aqueous adhesive composition and a process for preparing such compositions are disclosed. The composition comprises macromolecular complex comprising (A) a first component comprising (i) a framework element and (ii) a polyphenol, and (B) second component comprising a polypeptide, oligopeptide, amino acid, or polyamine. The framework element comprises (a) a polypeptide, oligopeptide, amino acid, or polyamine, (b) a polysaccharide, oligosaccharide, or monosaccharide, or a saccharide conjugate, or (c) a lignin, a lignan or a lignin conjugate. The polyphenol comprises a tannin, a tannic acid, a flavonoid, or a poly-resorcinol. An adhesive precursor composition comprising the first component is also disclosed.

A process of manufacturing a protein-polysaccharide macromolecular complex product containing encapsulated ethyl alcohol and/or other spirits serving to serve as an entertaining and novel non-beverage method of consuming alcohol. The process encapsulates ethyl alcohol and/or other spirits in the amorphous regions of a complex macromolecular structure releasing it only upon chewing and exposure to the environment of the oral cavity. The resulting product is stable and capable of retaining shape and form for extended periods of time at ambient temperature allowing for relatively low-cost commercial manufacture and distribution.

The invention discloses a purifying system for removing VOC (Volatile Organic Compounds) out of industrial waste gas. The purifying system comprises a filter A, a fan, a condenser A, a gas-liquid separator A, an iron-cobalt photocatalyst salinization effect dehalogenation reactor, an absorbing tower A, an absorbing tower B, an absorbing tower C, a PLC automatic control unit, a VOC gas detector, a steam generator, a filter B, an air compressor, a drier, a condenser B, a gas-liquid separator B and 17 sets of program control valves. The purifying system disclosed by the invention has the advantages that the metal photocatalyst salinization effect is creatively applied to uniformly diffuse iron-cobalt metallic elementary fine powder in the waste gas, and under the irradiation of blue light with specific wavelength, halogenated hydrocarbon in the waste gas VOC can generate photocatalystic reaction with elementary iron and cobalt, wherein halogen atoms are compounded with iron and cobalt to produce macromolecular complex salt so as to finish dehalogenation treatment of VOC; after the VOC waste gas is treated by dehalogenation, the consumption for the absorbing efficiency of active carbon can be greatly reduced, so that the absorbing efficiency of the active carbon is obviously improved.

An protein-polysaccharide macromolecular complex article of manufacture containing encapsulated ethyl alcohol and/or other spirits serving as an entertaining and novel non-beverage method of consuming alcohol. The article of manufacture encapsulates ethyl alcohol and/or other spirits in the amorphous regions of the complex macromolecular structure releasing it only upon chewing and exposure to the environment of the oral cavity. The article of manufacture is stable and capable of retaining shape and form for extended periods of time at ambient temperature allowing for relatively low-cost commercial manufacture and distribution.

The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.

The disclosure relates to the targeting of Y. pestis mediated by the binding activity of tail fibers from naturally occurring R-type pyocins from Pseudomonas aeruginosa. The targeting may be mediated by a macromolecular complex such as the pyocin itself, a high molecular weight (hmw) bacteriocin modified to have the tail fiber's binding activity, or a bacteriophage modified to have the tail fiber's binding activity. Compositions comprising such complexes are described. Also disclosed are methods for the use of a complex, such as to inhibit the growth of a Yersinia species like Y. pestis, by compromising the integrity of its cytoplasmic membrane are also described. Additional methods include use of the binding activity to identify Y. pestis.

The present invention relates to a process for repairing large member of tube mill unit by adopting high-molecular compound material. It is characterized by that it utilizes the metal characteristics possessed by high-molecular compound material and uses it as filling repairing material. Said process includes the following steps: according to the position, accuracy and number of area to be repaired, define reference surface, design and make applicable mould; clean member to be repaired, check the wear condition of surface to be repaired, process the surface to be repaired to required size; dress, clean, degrease and corrode the surface to be repaired; apply demoulding agent on surface of mould, prepairng high-molecular compound material, fill it in the surface to be repaired, mount mould and regulate it to define the position, demould after said compound material is solidified; dress and check repaired accuracy and performance.

The invention relates to a rhesus monkey erythrocyte adsorber, belonging to the field of medicine science. According to the rhesus monkey erythrocyte adsorber, rhesus monkey erythrocytes replace human Rh positive O erythrocytes, the rhesus monkey erythrocytes are washed by 4 DEG C normal saline and 37 DEG C normal saline, so that immune antibodies or natural antibody attaching to the surfaces of the erythrocytes can be removed, after antigenicity detection, cell sediment is added into a cylindrical adsorber made of a material with high biocompatibility till 4/5 of the volume is occupied, then 3.5% of mannitol erythrocyte preserving fluid is added, so that the concentration of the erythrocyte achieves 80%, shaking is carried out gently for uniform mixing, the opening is sealed, and the product is stored at 4 DEG C for regular use, wherein a screen is arranged at the opening of a purifier, so that a line of defense for preventing cell debris from being filtered out is formed, after the plasma is filtered, Rh antibodies are combined with Rh positive rhesus monkey erythrocytes to form a fixed compound, the broken erythrocyte debris and the macromolecular compound combined with the broken erythrocyte debris are blocked by the screen of the purifier, and the plasma with morbid substance removed is filtered by the purifier and then conveyed back, so that the purpose of treating blood-group-incompatible haemolytic diseases is achieved by eliminating Rh antibodies of the plasma.

The invention provides a treatment method of backflow coating liquid of paper-making-process reconstituted tobacco, and belongs to the technical field of paper-making-process reconstituted tobacco. According to the method, chitosan, Arabic gum, sodium alginate, glucolactone and other substances are added into the backflow coating liquid, net-structure macromolecular complexes formed by intermolecular forces among the substances such as the chitosan interact with calcium ion, calcium carbonate and fiber fines in the backflow coating liquid, interactions such as electrostatic interaction and gelation are generated, by the adoption of the generated interactions, the calcium ion, the calcium carbonate, the fiber fines and other substances in the backflow coating liquid can be effectively reduced, the purification treatment effect is significant, the viscosity and solid content of the backflow coating liquid are removed, the treated backflow coating liquid can be directly reused, and the treatment method of the backflow coating liquid has wide market prospects and relatively high application value.

The invention discloses a preparation method of biomacromolecule compound stable quercetagetin, and belongs to the technical field of transmission systems in function factor steady-state technology. According to the method, zein and propylene glycol alginate serve as raw materials, the quercetagetin serves as bioactive substances, a zein-propylene glycol alginate biomacromolecule compound loaded the quercetagetin is prepared by an anti-solvent co-precipitation method, the weight ratio of the zein to the propylene glycol alginate is 40:1-1:10, and the adding amount of the quercetagetin is 0.1wt%-2.0wt%. The dried biomacromolecule compound is spongy, water solubility of the quercetagetin is remarkably improved, the embedding rate of the quercetagetin is 90% or more, the loading amount of the quercetagetin is 6%-15%, the light degradation rate and the heat degradation rate of the quercetagetin are reduced, and the bioavailability of the quercetagetin is obviously improved. The preparation method can provide new ideas and new pathways for function factor stabilization.

The present invention relates to a method for production and purification of affinity tagged macromolecular complexes, such as ribosomes. More closely, the method comprises in-frame fusion of a nucleotide sequence specific for an affinity tag and a selection marker, wherein the fusion is at the chromosomal site of a gene encoding a multicopy protein, and wherein the macromolecular complex is expressed with multiple copies of said affinity tag. The invention also relates to affinity tagged ribosomes, to cells comprising such affinity tagged ribosomes, and to various uses thereof.

The invention relates to a maternal fetal blood group incompatibility antibody adsorption therapeutic apparatus in the field of medical science. The therapeutic apparatus is characterized in that Rh positive O-shaped red blood cells are cleaned by 4 DEG C and 37 DEG C normal saline and alternately washed by 25 and 35mmol/L of PB lysate with PH (potential of hydrogen) 7.4, D antigen containing ghost cells without hemoglobin are prepared, 80% cell concentration is formed by the aid of red blood cell storage solution with 3.5% mannitol, the ghost cells are placed in a cylindrical adsorber made of high-biocompatibility materials, sealed and stored at the temperature of 4 DEG C, and a screen is arranged at an outlet of the adsorber to form a defense line for preventing cell fragments from filtration. After plasma is filtered, Rh antibodies are combined into fixed complexes by the Rh positive red blood cells, the broken red blood cell fragments and macromolecular complexes formed by combination are intercepted by the screen of the adsorber, the plasma without morbid substances is filtered from the adsorber and then returned, and group incompatibility is treated by removing the Rh antibodies in the plasma.

The present invention relates to shear flow device 100 comprising cell 110, wherein the cell is static and comprises stationary plates 110a and 110b, and movable slide 130. The device of the present invention can be used in methods of orienting molecules for LD measurement and in methods for creating an oriented macromolecule or macromolecule complex.

A method of analyzing macromolecular complex ions, such protein complex ions, by mass spectrometry and apparatus for performing the method, wherein the method comprises: introducing macromolecular complex ions into a first fragmentation device and trapping the complex ions therein for a trapping period; fragmenting the trapped complex ions in the first fragmentation device to produce monomer subunit ions; optionally selecting one or more species of subunit ions by m/z; introducing one or more of the species of subunit ions into a second fragmentation device, spatially separated from the first fragmentation device; fragmenting the subunit ions in the second fragmentation device to produce a plurality of first fragment ions of the subunit ions; and mass analyzing the first fragment ions in a mass analyzer, or subjecting the first fragment ions to one or more further steps of fragmentation to form further fragment ions and mass analyzing the further fragment ions.

A method for characterizing interactions in macromolecular complexes, such as protein-protein or protein-ligand complexes, by selective isotopic labeling of the target molecule to reduce the ¹H density in a selected spectral region; by irradiating the target; and by monitoring the polarization using filtered nuclear Overhauser spectroscopy (NOESY) and/or by performing selective saturation transfer experiments to determine the docking potential of the macromolecular complex.

The invention provides a preparation method of white light macromolecular complex fluorescent powder containing europium, terbium and zinc. The preparation method solves the problems that the existingpreparation method easily causes insufficient coordination number of rare earth ions, and macromolecular ligands are difficult to reach energy level matching with different rare earth ions at the same time, resulting in poor luminescent performance and the like. The preparation method provided by the invention comprises the following steps: firstly, preparing macromolecular ligands; then, enabling the macromolecular ligands to coordinate with metal ions and cooperate with micromolecular ligands to prepare macromolecular complex fluorescent powder of three primary colors (red, green and blue);and performing blending to obtain the macromolecular complex white light fluorescent powder containing europium, terbium and zinc. The method has the advantages that the preparation process is simple, the data is accurate, and the luminescent performance of the white light fluorescent powder is better. Under the excitation of 365nm ultraviolet light, color coordinates x=0.330, y=0.338, so that the macromolecular complex white light fluorescent powder containing europium, terbium and zinc has good luminescent performance.