14 results about "Macromolecular Complexes" patented technology

This invention relates to the field of electroplating solution analysis technology, and in particular to a rapid analytical method for polyethylene glycol (PEG) additives in copper electrodeposition solutions. The method involves protonated PEG forming a macromolecular complex colloid with phosphomolybdate under acidic conditions of pH 1.0–2.0. This colloid exhibits maximum absorption at 372 nm, and the absorbance value is directly proportional to the PEG concentration in the formed complex colloid. This allows for quantitative analysis of PEG in the copper electrodeposition solution. Because the phosphomolybdate-PEG complex colloid selected in this invention has excellent selectivity, and no sample pretreatment is required, this invention offers advantages such as ease of operation, speed, high sensitivity, and good selectivity. It is particularly suitable for intermediate control analysis in production environments, such as for electroplated copper interconnects in chips and printed circuit boards, as well as electrolytic copper foil for negative electrode current collectors and copper-clad laminates in energy storage batteries.

Described herein are Methods, systems, compositions, and macromolecule complexes, for detecting, analyzing, evaluating, screening for, prognosing, diagnosing, and / or monitoring, pre-cancerous and cancerous conditions with abnormal cell growth in a patient, including patients having Minimal Residual Disease (MRD).

The invention provides an sgRNA molecule of a targeted IMP-4 gene and a biomacromolecular compound containing the sgRNA molecule, the biomacromolecular compound forms a CRISPR-Cas3 system for targeted removal of the IMP-4 drug-resistant gene, and the invention also provides a method for targeted removal of the IMP-4 drug-resistant gene in a strain by using the system. According to the CRISPR-Cas3 system provided by the invention, the directed gene clearance rate of the strain carrying the IMP-4 drug-resistant gene can reach 100%. The minimum inhibitory concentration of the Escherichia coli subjected to targeted removal of IMP-4 to meropenem is averagely reduced by 71.11 times compared with that of a strain without targeted removal of IMP-4.

The invention discloses a sewage treatment system and method. The sewage treatment system comprises an anaerobic-anoxic baffling reaction unit, a biological rotating disc reaction unit, a mixed liquid reflux unit and a precipitation unit, the anaerobic-anoxic baffling reaction unit comprises an anaerobic section and an anoxic section; in the anaerobic section, macromolecular complex organic pollutants in a sewage mixture are degraded into easily-degradable low-molecular organic matters by utilizing a first microbial flora, and at least part of the easily-degradable low-molecular organic matters are absorbed and energy is stored by utilizing a second microbial flora; in the anoxic section, a third microbial flora is used for carrying out denitrification reaction by taking at least part of easily degradable low-molecular organic matters as a carbon source, so that at least part of nitrate nitrogen in the sewage mixture is converted into nitrogen; the biological rotating disc reaction unit is used for nitrifying ammonia nitrogen in the sewage mixture into nitrate by utilizing the fourth microbial flora, and releasing energy and excessively absorbing phosphate in the sewage mixture in an aerobic environment by utilizing the second microbial flora.

The application provides a kind of electrolyte of aqueous zinc ion battery and its preparation method and application, including medium viscosity (200~400 mPa.s) chitosan and L-ascorbic acid, wherein the mass ratio of the chitosan added to the volume of the solvent in the electrolyte is 0.4 g / L~3.2g / L.The electrolyte of the application forms a macromolecular complex through ion adsorption by introducing chitosan and L-ascorbic acid, and establishes a dynamic and dense protective interface on the surface of zinc negative electrode by using its specific adsorption group (such as enediol structure), thereby achieving synergistic effect from two aspects of solvation structure regulation and interface chemical modification, and ultimately improving the cycle life and electrochemical performance of aqueous zinc ion battery.

This invention discloses an enhanced cement grinding aid and its preparation method, belonging to the technical field of cement admixtures. It is made from the following raw materials in parts by weight: 20-30 parts of an alcohol amine complex, 10-20 parts of ethylene glycol, 1-3 parts of a surfactant, 0.3-0.5 parts of a defoamer, 3-5 parts of a macromolecular synergist, 1-3 parts of a polycarboxylate superplasticizer, 0.5-1.5 parts of molasses, and 20-30 parts of water; the alcohol amine complex includes triethanolamine and modified alcohol amines; the macromolecular synergist is a sodium alginate-β-cyclodextrin macromolecular complex. This cement grinding aid can significantly improve cement grinding efficiency, increasing hourly output by more than 24.5%; the 3-day strength of cement increases by more than 5.9 MPa, and the 28-day strength increases by more than 10.7 MPa, showing good market application prospects.

The application discloses a kind of polyaspartic acid manganese polymer complex, it is characterized in that, its molecular structure formula is as shown in formula I: (I) Wherein, m is 1-33, n is 0-100.The polyaspartic acid manganese polymer complex provided in the application is prepared by one-step method chelation of polyaspartic acid ligand and manganese ion, process is simple and low in cost, as contrast agent, it has high relaxation efficiency and good biological safety, can realize kidney target enrichment, greatly improve the signal-to-noise ratio of MRI scanning, has excellent application prospect in kidney function evaluation and related disease diagnosis.

The invention relates to a drug depot using liquid-liquid phase separation (LLPS) by a macromolecule or macromolecular complex comprising an intrinsically disordered region (IDR) and at least one therapeutically active substance.

This invention discloses a key protein identification method based on two-stream supergraphs and multi-level gating in the field of multi-source bioinformatics. The method includes the following steps: S1, acquiring the target PPI network and multi-source biological heterogeneous attribute data, extracting network interaction edge data of the target protein, and constructing a basic PPI network view; S2, based on the PPI network view constructed in step 1, performing high-order topological information extraction based on local closed-loop subgraphs, thereby overcoming topological noise interference caused by inherent false positive edges in the basic interactive network, and deeply mining the synergistic interaction patterns of macromolecular complexes in spatial conformation. The algorithm of this invention exhibits good performance advantages in key protein identification, demonstrating that the dynamic fusion effect of high-order topology and multi-dimensional attributes is superior to single feature or homogeneous splicing strategies, providing a new approach and algorithm for solving the problem of accurate screening of key targets in complex biological networks.

The application discloses an oilfield anti-tearing and cold-resistant hydrogenated butyl nitrile rubber and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing a macromolecular complex functionalized grafting agent, and (2) preparing the oilfield anti-tearing and cold-resistant hydrogenated butyl nitrile rubber; the macromolecular complex functionalized grafting agent has the following structure: wherein R is a linear alkyl group with 1-6 carbon atoms; B is a capped 1,3-butadiene; n and m are the number of repeating units, n is a positive integer greater than or equal to 1, and m is a positive integer greater than or equal to 1; and the number average molecular weight (Mn) of the macromolecular complex functionalized grafting agent is 7000-8000. The preparation method of the oilfield anti-tearing and cold-resistant hydrogenated butyl nitrile rubber has the characteristics of green environmental protection, high modification efficiency, low modifier consumption, easy availability of raw materials on the market and suitability for industrial production.

The technology provided herein relates to multiplexing methods and kits for simultaneously detecting different analytes in a sample by using premixed macromolecular complexes, particularly complexes having a primary antibody and a secondary antibody, where the primary antibody contains the same identifier element.

The invention provides a yeast engineering bacterium for producing collagen and application thereof, and relates to the technical field of genetic engineering. A screening experiment shows that after the vps10-1 gene and the vps10-2 gene are knocked out or expression of the vps10-1 gene and the vps10-2 gene is inhibited, the degradation of human collagen in the process of producing collagen by saccharomycetes can be remarkably reduced, so that the stability and the accumulation level of the collagen are improved. The strategy not only relieves the problem of endogenous degradation of pichia pastoris from the source, but also provides a new thought for efficient expression of exogenous macromolecular complex proteins. Compared with a traditional method which is optimized through culture or uses an inhibitor, knockout at the gene level is more stable and efficient, and the method is more suitable for being applied under the large-scale fermentation condition.

The application discloses a kind of anti-tear, cold-resistant hydrogenated nitrile rubber for oil field and its preparation method, which comprises the following steps: (1) preparation of macromolecular complex functionalized long chain branch agent, (2) preparation of anti-tear, cold-resistant hydrogenated nitrile rubber for oil field;The macromolecular complex functionalized long chain branch agent has the following structure: wherein R is a linear alkyl group of C1-C6;B is capped 1,3-butadiene;n and m are the number of repeating units, n≥1, m≥1 positive integer;The number average molecular weight (Mn) of the macromolecular complex functionalized long chain branch agent is 7000-8000.The preparation method of the anti-tear, cold-resistant hydrogenated nitrile rubber for oil field has the characteristics of green environmental protection, high efficiency of modification effect, low dosage of modifier, easy to get raw materials on the market, suitable for industrial production, etc.

The invention relates to a drug depot using liquid-liquid phase separation (LLPS) by a macromolecule or macromolecule complex comprising an intrinsically disordered region (IDR) and at least one therapeutically active substance.