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Polymersome with dual response to ultrasound and pH and method for preparing same

A technology of polymers and vesicles, applied in the fields of polymer materials and medical engineering, to achieve the effect of simple and convenient operation

Active Publication Date: 2014-07-16
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of ultrasound in controlled drug release has attracted much attention, but relatively stable ultrasound-responsive polymersomes capable of encapsulating hydrophilic and hydrophobic drugs have not been reported.

Method used

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  • Polymersome with dual response to ultrasound and pH and method for preparing same
  • Polymersome with dual response to ultrasound and pH and method for preparing same
  • Polymersome with dual response to ultrasound and pH and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Macromolecular initiator PEO 43 -Synthesis of Br

[0048] Add 10g of PEO (molecular weight: 1900) and 250mL of toluene into a 500mL round bottom flask, and remove water azeotropically at a temperature of 140°C;

[0049] After cooling to room temperature, place the flask in an ice-salt bath, add 2 mL of triethylamine, and add 20 mL of toluene solution dissolved in 2 mL of 2-bromoisobutyryl bromide dropwise at a rate of 3 seconds per drop using a constant pressure dropping funnel. After the dropwise addition, the reaction was carried out under sealed stirring for 30 hours (wherein, the molar ratio of 2-bromoisobutyryl bromide to polyethylene oxide was 2:1, and the molar ratio of triethylamine to 2-bromoisobutyryl bromide than 1:1). Filtration, extraction, washing, drying, dissolution, precipitation, and finally vacuum drying to obtain the white powdery macromolecular initiator PEO 43 -Br (molecular weight: 2025);

[0050] (2) Synthesis of Tetrahydrofuran Hydroxyet...

Embodiment 2

[0060] (1) Macromolecular initiator PEO 43 -Synthesis of Br

[0061] Add 10g of PEO (molecular weight: 1900) and 250mL of toluene into a 500mL round bottom flask, and remove water azeotropically at a temperature of 140°C. After cooling to room temperature, place the flask in an ice-salt bath, add 2 mL of triethylamine, and add 20 mL of toluene solution dissolved in 2 mL of 2-bromoisobutyryl bromide dropwise at a rate of 3 seconds per drop using a constant pressure dropping funnel. After the dropwise addition, the reaction was carried out under sealed stirring for 30 hours (wherein, the molar ratio of 2-bromoisobutyryl bromide to polyethylene oxide was 2:1, and the molar ratio of triethylamine to 2-bromoisobutyryl bromide than 1:1). Filtration, extraction, washing, drying, dissolution, precipitation, and finally vacuum drying to obtain the white powdery macromolecular initiator PEO 43 -Br (molecular weight: 2025).

[0062] (2) Synthesis of Tetrahydrofuran Hydroxyethyl Metha...

Embodiment 3

[0072] (1) Macromolecular initiator PEO 43 -Synthesis of Br

[0073] Add 10g of PEO (molecular weight: 1900) and 250mL of toluene into a 500mL round bottom flask, and remove water azeotropically at a temperature of 140°C. After cooling to room temperature, place the flask in an ice-salt bath, add 2 mL of triethylamine, and add 20 mL of toluene solution dissolved in 2 mL of 2-bromoisobutyryl bromide dropwise at a rate of 3 seconds per drop using a constant pressure dropping funnel. After the dropwise addition, the reaction was carried out under sealed stirring for 30 hours (wherein, the molar ratio of 2-bromoisobutyryl bromide to polyethylene oxide was 2:1, and the molar ratio of triethylamine to 2-bromoisobutyryl bromide than 1:1). Filtration, extraction, washing, drying, dissolution, precipitation, and finally vacuum drying to obtain the white powdery macromolecular initiator PEO 43 -Br (molecular weight: 2025).

[0074] (2) Synthesis of Tetrahydrofuran Hydroxyethyl Metha...

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Abstract

The invention belongs to the field of high polymer materials and medical engineering and specifically relates to a polymersome with dual response to ultrasound and pH and method for preparing the same. Amphipathic block-random polymers are self-assembled to form the polymersome by a solvent exchange method; the polymersome has dual response to ultrasound and pH and is used as a drug carrier; under the ultrasonic effect, the structure of the polymersome is changed so that the drug coated and carried by the polymersome is released quickly; the change of the pH values at different parts in the body is capable of triggering the pH response chain segment to respond, thereby achieving the auxiliary effect; and the polymersome has bright application prospect in drug loading technical aspect.

Description

technical field [0001] The invention belongs to the field of polymer materials and medical engineering, and relates to a polymer vesicle and a preparation method thereof. Background technique [0002] In recent years, with the development of polymer synthesis methods (free self-polymerization, cationic polymerization, anionic polymerization, group transfer radical polymerization, atom transfer radical polymerization (ATRP), reversible-addition-fragmentation chain transfer polymerization (RAFT), etc. With the development of assembly technology, more and more intelligent polymersomes have become a research hotspot. [0003] Due to the difference in the performance of the block copolymers, the solubility of each segment in the solvent is different, so that the polymer molecular chain self-assembles to form various forms of assemblies. The morphology of the polymer self-assembly found so far Mainly include: spherical micelles, rod-shaped micelles, disc-shaped micelles, spherica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00C08F220/34C08F220/32C08G65/48C08J3/12A61K47/32A61K41/00
Inventor 杜建忠陈文钦
Owner TONGJI UNIV
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