Preparation method of high-water-absorption sodium alginate composite nanofiber wound dressing

A technology of composite nanofiber and sodium alginate, which is applied in the field of medical and health materials to achieve the effect of easy control of material structure and performance, reduction of infection, and promotion of wound healing

Inactive Publication Date: 2016-11-16
INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The preparation of sodium alginate nanofibers by electrospinning above only studies the process and the preliminary drug release performance of the material, but there is no research on the water absorption of the material. In fact, as a new type of wound dressing, water absorption is a very important application. Performance indicators, obtaining highly water-absorbent sodium alginate nanofibers can maintain a moist environment on the wound surface, and it is expected to be well applied in wound dressings

Method used

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  • Preparation method of high-water-absorption sodium alginate composite nanofiber wound dressing
  • Preparation method of high-water-absorption sodium alginate composite nanofiber wound dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Weigh 1 gram of sodium alginate and 8 grams of PVA, add 100ml of a mixture of deionized water and ethanol (the volume ratio of water and ethanol is 9:1), stir magnetically in a water bath at 80°C for 2 hours to dissolve and form a transparent solution, and then add 1 gram of methyl alcohol Glycidyl acrylate, continue to stir and react for 2 hours, cool to room temperature to obtain a transparent spinning solution, put the spinning solution into a liquid storage device, and use an electrospinning device to prepare a sodium alginate composite nanofiber membrane material. Spinning conditions: voltage 30KV, solution flow rate 3ml / h, distance 10cm. The prepared sodium alginate composite nanofiber membrane material was vacuum dried in a vacuum oven for 2 days. Then transfer it to a blast drying oven, and perform cross-linking treatment at 100° C. for 24 hours to obtain a superabsorbent sodium alginate composite nanofiber membrane. The prepared material absorbs liquid up to 1...

Embodiment 2

[0026] Weigh 1 gram of sodium alginate and 8 grams of PVA, add 100ml of a mixture of deionized water and ethanol (the volume ratio of water and ethanol is 8:2), stir magnetically in a water bath at 80°C for 2 hours to dissolve and form a transparent solution, and then add 0.5 grams of methyl alcohol Glycidyl acrylate, continue to stir and react for 2 hours, cool to room temperature to obtain a transparent spinning solution, put the spinning solution into a liquid storage device, and use an electrospinning device to prepare a sodium alginate composite nanofiber membrane material. Spinning conditions: voltage 30KV, solution flow rate 3ml / h, distance 10cm. The prepared sodium alginate composite nanofiber membrane material was vacuum dried in a vacuum oven for 2 days. Then transfer it to a blast drying oven, and perform cross-linking treatment at 120° C. for 24 hours to obtain a superabsorbent sodium alginate composite nanofiber membrane. The prepared material absorbs liquid up t...

Embodiment 3

[0028] Weigh 1 g of sodium alginate and 10 g of PEO, add 100 ml of a mixture of deionized water and ethanol (volume ratio of water and ethanol is 9:1), stir magnetically in a water bath at 80°C for 2 hours to dissolve to form a transparent solution, and then add 0.5 g of methyl Glycidyl acrylate, continue to stir and react for 2 hours, cool to room temperature to obtain a transparent spinning solution, put the spinning solution into a liquid storage device, and use an electrospinning device to prepare a sodium alginate composite nanofiber membrane material. Spinning conditions: voltage 30KV, solution flow rate 3ml / h, distance 10cm. The prepared sodium alginate composite nanofiber membrane material was vacuum dried in a vacuum oven for 2 days. Then transfer it to a blast drying oven, and perform cross-linking treatment at 120° C. for 24 hours to obtain a superabsorbent sodium alginate composite nanofiber membrane. The prepared material absorbs liquid up to 10 times its own wei...

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Abstract

The invention provides a preparation method of a high-water-absorption sodium alginate composite nanofiber wound dressing. According to the method, sodium alginate, a water-soluble polymer and a cross-linking agent are dissolved into a mixture of water and ethyl alcohol to prepare a spinning solution; sodium alginate composite nanofibers are prepared through an electrospinning technique, and then a cross-linking reaction is generated through heating to obtain the high-water-absorption sodium alginate composite nanofiber wound dressing. The method comprises the steps of 1 preparation of the spinning solution, 2 preparation of the nanofibers through electrospinning and 3 preparation of high-water-absorption sodium alginate composite nanofibers through cross-linking treatment on the nanofibers. According to the preparation method, the high-water-absorption sodium alginate composite nanofiber wound dressing is prepared through a special process, the defects that an existing alginic acid fiber medical dressing is fragile and poor in air permeating and moisture absorbing effect are overcome, the multifunctional wound dressing can be provided for multiple skin wounds and different repairing stages, and the effects of sterilizing, bleeding stopping, pain relieving, infection reducing, wound healing promoting and the like are achieved.

Description

technical field [0001] The invention relates to a preparation method of a superabsorbent sodium alginate composite nanofiber wound dressing, which belongs to the technical field of medical and sanitary materials. Background technique [0002] Medical wound dressings are a class of important biomedical materials used to cover sores, wounds or other injuries, and their research and development have always been a hot topic. Traditional wound dressings mainly include ordinary plant fibers, carboxymethyl cellulose, chitosan, etc., but there are many problems such as single product types and functions, no series of products, and functional defects. In recent decades, a large number of basic researches and clinical treatments on wounds have verified that providing a suitable moist environment for wounds is conducive to wound healing. The new absorbent dressing can not only keep the wound surface moist but also promote wound healing. At present, new dressings are widely used in de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/26A61L15/42C08J3/24D01D5/00
CPCA61L15/225A61L15/42A61L2400/04C08J3/24C08J2329/04C08J2371/02C08J2405/04D01D5/003D01D5/0069D01D5/0076D01D5/0092C08L5/04C08L29/04C08L71/02C08L5/08
Inventor 孙复钱张鹏胡银王小玉曾国屏
Owner INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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