Preparation method of high-water-absorption sodium alginate composite nanofiber wound dressing

Abstract

The invention provides a preparation method of a high-water-absorption sodium alginate composite nanofiber wound dressing. According to the method, sodium alginate, a water-soluble polymer and a cross-linking agent are dissolved into a mixture of water and ethyl alcohol to prepare a spinning solution; sodium alginate composite nanofibers are prepared through an electrospinning technique, and then a cross-linking reaction is generated through heating to obtain the high-water-absorption sodium alginate composite nanofiber wound dressing. The method comprises the steps of 1 preparation of the spinning solution, 2 preparation of the nanofibers through electrospinning and 3 preparation of high-water-absorption sodium alginate composite nanofibers through cross-linking treatment on the nanofibers. According to the preparation method, the high-water-absorption sodium alginate composite nanofiber wound dressing is prepared through a special process, the defects that an existing alginic acid fiber medical dressing is fragile and poor in air permeating and moisture absorbing effect are overcome, the multifunctional wound dressing can be provided for multiple skin wounds and different repairing stages, and the effects of sterilizing, bleeding stopping, pain relieving, infection reducing, wound healing promoting and the like are achieved.

Description

technical field [0001] The invention relates to a preparation method of a superabsorbent sodium alginate composite nanofiber wound dressing, which belongs to the technical field of medical and sanitary materials. Background technique [0002] Medical wound dressings are a class of important biomedical materials used to cover sores, wounds or other injuries, and their research and development have always been a hot topic. Traditional wound dressings mainly include ordinary plant fibers, carboxymethyl cellulose, chitosan, etc., but there are many problems such as single product types and functions, no series of products, and functional defects. In recent decades, a large number of basic researches and clinical treatments on wounds have verified that providing a suitable moist environment for wounds is conducive to wound healing. The new absorbent dressing can not only keep the wound surface moist but also promote wound healing. At present, new dressings are widely used in de...

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Problems solved by technology

[0005] The preparation of sodium alginate nanofibers by electrospinning above only studies the process and the preliminary drug release performance of the material, but there is no research on the water absorption of the material. In fact, as a new type of wound dressing, water absorption is a very important application. Performance indicators, obtaining highly water-absorbent sodium alginate nanofibers can maintain a moist environment on the wound surface, and it is expected to be well applied in wound dressings

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