Fiber with multiple core-shell structures and preparation method thereof

A technology with a shell structure and multiple cores, which is applied in the field of fibers with multiple core-shell structures and its preparation, can solve the problems of difficult and difficult preparation methods, and achieve controllable morphology and structure, convenient operation, and designability and practical effect

Inactive Publication Date: 2013-06-05
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional preparation methods, such as melt spinning, wet spinning, electrospinning, etc., have encountered difficulties in the preparation of fibers with complex structures and functions due to the limitations of their processes and principles.
Especially in the field of biotechnology, as a three-dimensional carrier for cell culture, fibers can simultaneously complete cell encapsulation and fiber preparation without destroying cell activity, which is difficult to achieve with traditional preparation methods

Method used

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  • Fiber with multiple core-shell structures and preparation method thereof
  • Fiber with multiple core-shell structures and preparation method thereof

Examples

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preparation example Construction

[0040] The present invention uses microfluidic technology to design and build a microfluidic chip according to the structure and function of multi-component fibers, and can prepare fibers 4 with multiple core-shell structures by adjusting the components and flow rates of each phase solution. Fiber 4 with multiple core-shell structures, each layer is distinguished by its material and function. The material of each fluid channel 3 is selectively used to wrap functional nanoparticles, drugs or cells, and can be applied in fields such as cell culture, drug sustained release, and tissue engineering. Compared with the traditional fiber preparation method, the method proposed by the invention has simple device, convenient operation, stronger designability and practicability of the fiber. Its specific preparation method comprises the following steps:

[0041] (1) Preparation steps of microfluidic chip:

[0042] Use the method of micromachining to prepare the channel network. The mat...

Embodiment 1

[0046] Example 1 Preparation of fiber 4 with two-layer core-shell structure:

[0047] 1. Preparation of microfluidic chip:

[0048] A circular PDMS channel network is prepared by micromachining. The channel network includes two coaxially nested fluid channels 3, two continuous phase channels 2, and a co-flow channel 1. The interior of each channel is treated with hydrophobicity. .

[0049] 2. Preparation of fiber:

[0050] (1) Configuration of each phase solution:

[0051] Fluid phase solution 1: Add monodisperse silica nanoparticles with a diameter of 180 nm to the aqueous solution of polyethylene glycol diacrylate, adjust the mass fraction of silicon dioxide to 40%, and the content of polyethylene glycol diacrylate The mass fraction is 10%, ultrasonically dispersed until the colloidal particle solution produces a bright color; add the initiator 2-hydroxyl-2-methylpropiophenone (1%, volume ratio) to the above solution, mix well, and seal the backup use.

[0052] Fluid ph...

Embodiment 2

[0056] Example 2 Preparation of fibers with a hollow structure of two layers of core-shell:

[0057] 1. Preparation of microfluidic chip:

[0058] Use an acetylene blowtorch or a microelectrode puller to draw three kinds of glass capillary tubes so that one end becomes a tapered tip, and polish it on sandpaper until the tip is smooth and the inner diameter of the tip of the single tube is 40 microns and 100 microns respectively , 200 microns, placed in alcohol for ultrasonic cleaning, and blown dry with nitrogen; using a glass plate as a substrate, insert a capillary with an inner diameter of 200 microns into a capillary with an inner diameter of 580 microns, adjust the tip to the central axis of the capillary, and follow the above steps Nest the 100-micron capillary in the 200-micron tube, the 40-micron capillary in the 100-micron tube, install the needle, and fix it with quick-drying adhesive.

[0059] 2. Preparation of fiber:

[0060] (1) Configuration of each phase solut...

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Abstract

The invention discloses a fiber with multiple core-shell structures. The fiber is provided with the multiple core-shell structures. The diameter of the fiber is 10 microns to 1*106 microns, and the length of the fiber is more than one 1 micron. The cross section of the fiber is in a circular shape or a hollow ring shape. The invention further provides a preparation method of the fiber. With the structure, the fiber with the multiple core-shell structures is controllable in morphology and structure, and the preparation method is convenient and fast to operate, and designability and piratical applicability of the fiber are strong. Packaging miscellaneous nano particles, medicines or living cells can be achieved. The fiber with the multiple core-shell structures can be applied in the fields of cell cultivation, medicine sustained release, tissue engineering and the like.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a fiber with multiple core-shell structures and a preparation method thereof. Background technique [0002] Fiber refers to a substance consisting of continuous or discontinuous filaments. There are natural fibers in nature, which can be obtained directly from plants, animals and mineral rocks, such as flax, jute, wool, rabbit hair, mineral fibers, etc., which can be seen everywhere in daily life. Compared with natural fiber, chemical fiber is a kind of fiber processed by chemical treatment. With its wide range of raw materials and many types, it is widely used in high-tech fields such as textile industry, military, environmental protection, medicine, construction, and biotechnology. application. With the development of science and technology, people have more and more needs for the structure and function of fibers, and are no longer limited to fibers with a single compone...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01D5/34D01D5/24
Inventor 赵远锦程瑶商珞然顾忠泽
Owner SOUTHEAST UNIV
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