Process for producing sulfanilic amide medicine mother substance p-acetamido benzene sulfonyl chloride

A technology of acetamidobenzenesulfonyl chloride and production process, which is applied in the field of production technology of sulfonamide drug parent-p-acetamidobenzenesulfonyl chloride, can solve problems such as failure to obtain economical, effective and applicable technical measures, and achieves environmental protection and saving Water use, the effect of improving economic efficiency

Inactive Publication Date: 2005-10-19
黄升
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Problems solved by technology

Domestic scientific research departments and colleges and universities have conducted rese

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  • Process for producing sulfanilic amide medicine mother substance p-acetamido benzene sulfonyl chloride
  • Process for producing sulfanilic amide medicine mother substance p-acetamido benzene sulfonyl chloride

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Embodiment Construction

[0008] refer to figure 2 , this embodiment is firstly the chlorosulfonation reaction: add 1000L chlorosulfonic acid into a 2000L sulfonation kettle, start stirring, and cool the jacket with ice water; under slight negative pressure, slowly add acetanilide from the high-level silo , add 400Kg of acetanilide within 1.5 hours; keep the reaction temperature at 48-50°C; react for 6 hours, cool down to 30°C to obtain sulfonated oil, pump it into a static reaction tank, and keep it warm for 8 hours; by-product hydrogen chloride gas enters hydrochloric acid The absorption tower absorbs the by-product hydrochloric acid. Jingyifen: pump the sulfonated oil into a subdivision kettle, and pass through the jacket with frozen brine; add 1 / 10 of the oil volume washing water dropwise at 20-22°C to decompose the chlorosulfonic acid, and the hydrogen chloride gas produced enters the hydrochloric acid The absorption tower absorbs and obtains by-product hydrochloric acid. After two points: In a...

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Abstract

The production process of p-acetamido benzene sulfonyl chloride as intermediate for sulfanilamide medicine includes the following steps: chlorosulfonating acetylaminobenzene as main material with chlorosulfonic acid to produce sulfonated oil and absorbing hydrogen chloride gas to prepare hydrochloric acid; separating sulfonated oil, adding water and decomposing chlorosulfonic acid to obtain separated oil while absorbing produced hydrogen chloride gas; separating the separated oil and adding water to deposit out p-acetamido benzene sulfonyl chloride; further separating, eliminating p-acetamido benzene sulfonyl chloride mother liquid, water washing the crystal while side producing sulfuric acid; using the side produced sulfuric acid in recovering p-amido benzene sulfonic acid; and reusing crystal eliminating water in the separation. The present invention realizes the comprehensive utilization, protects environment and lowers the cost.

Description

technical field [0001] The invention belongs to a production process for preparing sulfonamide drug parent material-paracetamol sulfonyl chloride from sulfonated oil. Background technique [0002] Sulfonamides are one of four classes of anti-infective drugs. Due to the good antibacterial effect of sulfa drugs, mature technology, easy access to raw materials, and low price, they have maintained a certain market share after decades of clinical use. my country is a big producer of sulfonamides and a big user of the drug, with an annual output of about 10,000 tons, most of which are sold to overseas international markets. After decades of hard work by medical personnel, the technical level and equipment have undergone great changes, and the production process is mature and stable. Traditional technical process is: take acetanilide as raw material, prepare p-acetamidobenzenesulfonyl chloride (hereinafter referred to as ASC) through chlorosulfonation of chlorosulfonic acid; the ...

Claims

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Application Information

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IPC IPC(8): C07C303/08C07C309/83
Inventor 黄升
Owner 黄升
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