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Compound in alpha (pyrazole formyloxy) acetanilide class of possessing fungicidal property

A technology of acetanilide and pyrazole carboxylic acid, applied in the fields of organic chemistry, biocides, animal repellents, etc., can solve the problem that the bactericidal activity has not been disclosed.

Inactive Publication Date: 2005-06-15
中国中化股份有限公司 +1
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

But the α-(pyrazole carboxyl) acetanilide compound and its bactericidal activity as shown in the present invention have not been disclosed

Method used

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  • Compound in alpha (pyrazole formyloxy) acetanilide class of possessing fungicidal property
  • Compound in alpha (pyrazole formyloxy) acetanilide class of possessing fungicidal property
  • Compound in alpha (pyrazole formyloxy) acetanilide class of possessing fungicidal property

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Synthetic example

[0064] Synthesis of Compound 41 in Table 1:

[0065]

[0066] A1 A2 B1

[0067] Add A1 (15 grams, 0.259 moles) in 500 milliliters of reaction flasks, sodium methylate (58 grams, 28%, 0.300 moles) and 100 milliliters of anhydrous methanols, under water-bath stirring, dropwise add A2 (36.7 grams, 0.251 moles) 50 ml of methanol solution was dropped in 4 hours, the water bath was removed, and the reaction was continued for 2 hours at room temperature. Under ice-water cooling, 200 milliliters of water and 200 milliliters of dichloromethane were added to the reaction solution, then the pH value was adjusted to 3 with concentrated hydrochloric acid, the layers were separated, the aqueous layer was extracted with 200 milliliters of dichloromethane, the organic layers were combined, and the organic layer was Wash with 200 ml of saturated aqueous sodium chloride, dry over anhydrous magnesium sulfate, and precipitate under reduced pressure to obtain 24 g of yellow oil B1.

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Abstract

An alpha-(pyrazole-formyl) acetylphenylamine compound with high bactericiding activity and its formula are disclosed.

Description

technical field [0001] The invention belongs to the field of fungicides. Background technique [0002] Because fungicides or their compositions are used for a period of time, bacteria will develop resistance to them, therefore, there is a constant need to invent new and improved fungicidal compounds and compositions. In addition, considering factors such as economy and environment, it is also necessary to invent fungicides with different action mechanisms from existing fungicides. [0003] The preparation of certain α-(benzoyl)acetanilides has been reported (J. Chem. Soc. Perkin II, 1977, 2028-2032). However, the α-(pyrazole carboxyl)acetanilide compound and its fungicidal activity as shown in the present invention have not been disclosed. Contents of the invention [0004] The present invention provides a novel α-(pyrazole carboxyl)acetanilide compound, as shown in general formula (I): [0005] [0006] in: [0007] R 1 for C 1 -C 4 Alkyl, C 2 -C 6 Alkenyl, C ...

Claims

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Application Information

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IPC IPC(8): A01N43/56C07D231/12
Inventor 李斌张珂良李志念王力钟邹军贾永刚刘振龙吴鸿飞
Owner 中国中化股份有限公司
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