44 results about "Iodophenol" patented technology

Photodynamic therapy-based methods of treating diseases such as cancer and malaria are disclosed. These methods include administering 5-aminolevulinic acid (ALA), luminol and artemisinin (ART). ART and ALA administered in combination with luminol can kill malaria parasites without host toxicity. In some aspects, the methods further include administration of a luminol enhancer such as 4-iodophenol. The disclosed methods can also be used to remove potential malaria pathogens from the blood supply.

The invention discloses a preparation method of 4, 4'-biphenol. The preparation method comprises the following steps: adding 4-iodophenol, zinc powder, alkali and a solvent into a reaction bottle, replacing air in the reaction bottle with nitrogen for three times, adding triethylamine formate into the reaction bottle under the protection of nitrogen, stirring for 30-60 minutes, heating to reflux,reacting for 1-16 hours, cooling the reaction liquid to room temperature, filtering, and concentrating filtrate to dryness to obtain 4, 4'-biphenol.

Provided is a method for simultaneously detecting oxytetracycline, tetracycline and kanamycin based on ABEI modified flower-shaped nanogold. The method is characterized by comprising the steps that the chemiluminescence time can be effectively prolonged based on a N-(4-ammonia butyl)-N-ABEI-H2O2-p-iodophenol (PIP) steady-state chemiluminescence system constructed by a microwell plate; a sulfhydrylation complementary chain is connected with ABEI modified flower-shaped nanogold to be used for a signal probe; aptamers fixed on the microwell plate are used as molecular recognition elements, and the aptamers of three antibiotics are fixed on three regions of the microwell plate respectively to provide spatial resolution for simultaneous detection of targets. The constructed aptamer sensor can achieve simultaneous detection on oxytetracycline, tetracycline and kanamycin, and the chemiluminescence intensity of the sensor is in negative logarithm correlation with the quantity of the targets. In addition, the sensor is used for practical sample detection, and the good property of the sensor is proved.

To provide a process for producing 2-iodophenol derivatives or 2,6-diiodophenol derivatives by iodinating phenol derivatives at ortho position which can dispense the recovery of iodine and makes it possible to produce the objective iodinated derivatives at low cost, in high yield, and with high quality. High-quality 2-iodophenol derivatives or 2,6-diiodophenol derivatives can be obtained in high yield by reacting a phenol derivative with molecular iodine in the presence of a pyridine and either hydrogen peroxide or iodic acid as oxidizing agent through efficient iodination with a nearly theoretical amount of iodine based on the starting phenol derivative.

The invention discloses a preparation method of 4,4'-biphenyldiphenol, which comprises: adding 4-iodophenol, zinc powder, alkali and solvent into a reaction bottle, replacing the air in the reaction bottle with nitrogen three times, and protecting the reaction bottle with nitrogen. Add triethylamine formate to the reaction bottle, stir for 30-60 minutes, heat to reflux, react for 1-16 hours, cool the reaction solution to room temperature, filter, and concentrate the filtrate to dryness to obtain 4,4'-biphenyl diphenols.

The invention discloses a supermolecular disc liquid-crystal compounds and process for preparation, wherein the compound has the structural formula disclosed in the specification, wherein n=1-6, its preparation process comprises, introducing alkyl into 2-methoxyl-5-iodophenol, carrying out Ullmann coupling, free radical coupling and demethylating reaction, constructing triphenylene precursor, then introducing lateral chain with ester group as the end group, and hydrolyzing the ester group into acids.

The invention discloses a photodynamic treatment medical composition which consists of a photosensitizer and a chemical activator, wherein the photosensitizer is expressed by the formula I; the chemical activator comprises luminol, p-iodophenol, horse radish peroxidase and hydrogen peroxide; and the proportion of the photosensitizer expressed by the formula I, to the luminol to the p-iodophenol to the horse radish peroxidase to the hydrogen peroxide in the composition is 8-12muM:0.4-0.7mM:1-1.5mM:0.01-0.02mg / mL:2-3mM. In the composition of the invention, active oxygen generated by bioluminescence energy transfer between the photosensitizer expressed by the formula I and the luminol is utilized to kill cells and fungi. Compared with the traditional photodynamic treatment method, the composition can be used for treating in deep tissues; and damages to normal tissues, which are caused by long-time irradiation by an external light source, can be avoided; and meanwhile, the composition has a profound influence on the aspects of the clinic treatment of tumors and pathogenic bacteria infection.

The present invention relates to the synthesis process of 2-methoxyl-5-iodophenol. The synthesis process includes the following steps: the reaction of 2-methoxyl-phenol and p-toluenesulfonyl chloride in triethylamine solvent to prepare p-toluenesulfo-(2-methoxyl) phenol ester; the reaction of p-toluenesulfo-(2-methoxyl) phenol ester, metal chloride and iodine monochloride to produce great amount of solid; suction filtering, washing with glacial acetic acid and water washing to obtain p-toluenesulfo-(2-methoxyl-5-iodo) phenol ester; and final deprotection of p-toluenesulfo-(2-methoxyl-5-iodo) phenol ester to obtain 2-methoxyl-5-iodophenol. The present invention has the advantages of simple operation, low material cost, high yield, high product purity, etc. and is suitable for industrial production.

The invention discloses an amphiphilic anticancer photosensitizer with a big two-photon absorption section as well as preparation and application thereof. The preparation of the amphiphilic anticancer photosensitizer comprises the following steps: under the action of ZnP, BD, 4-iodophenol tetrakis (triphenylphosphine) palladium and CuI, preparing an intermediate BD-ZnP-OH; then enabling the intermediate to react with diiodo tetraethylene glycol under the action of potassium carbonate and preparing an intermediate BD-ZnP-I; finally preparing the amphiphilic anticancer photosensitizer BD-ZnP-P through the intermediate and the triphenylphosphine. Through spectroscopic analysis, the obtained very high singlet oxygen quantum yield of the photosensitizer is 49 percent; finally, as the photosensitizer has the very big two-photon absorption section, 1725 GM is reached; meanwhile, in-vitro photodynamic test results in HeLa, A549, MCF-17 and HK-1 tumor cells show that the amphiphilic anticancer photosensitizer has very good tumor cell permeability and tumor cell killing ability under photo-induction.

The present invention relates to the technical field of drug synthesis, in particular to a method for preparing 2,4,6-triiodoresorcinol, that is, in sulfuric acid methanol solution, using resorcinol as a substrate, potassium iodide as an iodine reagent, and dropping Hydrogen peroxide aqueous solution is added, and the highly active, nascent atomic iodine and resorcinol generated by the oxidation of potassium iodide by hydrogen peroxide react to produce products; the by-products are water and inorganic salts. The method for synthesizing iodophenol of the present invention is an oxidation iodization process, and the highly active iodide iodine chloride generated in the process is immediately generated and consumed by iodine immediately, and the by-products of the reaction are water and potassium sulfate; the reaction is green, efficient, and Safe and controllable.

The invention provides a chemiluminescent substrate solution, which comprises the following components: 0.2-1.2g / L of Luminol, 0.1-5g / L of cinnamic acid, 0.05-0.6g / L of 4-iodophenylboronic acid, 0.05-0.6 g / L of p-iodophenol, 5-50ml / L of dimethylformamide (DMF), 2.5-7.5 g / L of polyvinyl alcohol (PVA), 5-15g / L of polyvinyl pyrrolidone (PVP), 1.5-5g / L of polyethylene glycol 600 (PEC -600), 1-10g / L of ethylene diamine tetraacetic acid (EDTA), 400,000-4,000,000 unit / L of gentamicin sulfate, 0.1-1.0g / L of carbamide peroxide and 0.1mol / L of tris buffer solution with a pH vale being 9.0. The chemiluminescent substrate solution is a solution which can be directly used, and maintains wide linear detection range, good stability and high sensitivity, thus solving the problem that a traditional chemiluminescent substrate solution consists of a solution A and a solution B which are stored separately; and after the solution A and the solution B are isovolumetrically mixed for 10 minutes, signal values are decreased sharply, the detection range is narrowed and the stability is poor. In addition, the chemiluminescent substrate solution provided by the invention is easy to prepare, low in cost and simple to operate, environmentally friendly, and non-toxic and harmless to human bodies and the like.

Provided is a method for simultaneously detecting oxytetracycline, tetracycline and kanamycin based on ABEI modified flower-shaped nanogold. The method is characterized by comprising the steps that the chemiluminescence time can be effectively prolonged based on a N-(4-ammonia butyl)-N-ABEI-H2O2-p-iodophenol (PIP) steady-state chemiluminescence system constructed by a microwell plate; a sulfhydrylation complementary chain is connected with ABEI modified flower-shaped nanogold to be used for a signal probe; aptamers fixed on the microwell plate are used as molecular recognition elements, and the aptamers of three antibiotics are fixed on three regions of the microwell plate respectively to provide spatial resolution for simultaneous detection of targets. The constructed aptamer sensor can achieve simultaneous detection on oxytetracycline, tetracycline and kanamycin, and the chemiluminescence intensity of the sensor is in negative logarithm correlation with the quantity of the targets. In addition, the sensor is used for practical sample detection, and the good property of the sensor is proved.

The invention discloses an industrial preparation method of 2-bromo-5-iodophenol. According to the industrial preparation method of the 2-bromo-5-iodophenol, ortho-nitroaniline serves as an initial raw material, and the 2-bromo-5-iodophenol is synthesized by iodination, diazotization bromination, reduction and diazotization phenol hydroxylation four-step reaction. The 2-bromo-5-iodophenol obtainedin the process is blue solid with the purity of 97.5%, raw material conversion rate in each step reaches 100%, and the total yield of the whole process reaches 17%.

The invention discloses chemiluminescent substrate liquid, which is mainly composed of radiant agent luminol, reinforcing agent p-Iodophenol, oxidant urea peroxide, and is applied to a detection system taking HRP as enzymatic reaction. The chemiluminescent substrate liquid has the characteristics of short reaction time, long detection platform period, good stability and the like, and can enhance the sensitivity of a kit, broaden linear range and prolong the period of validity of the kit.