The invention relates to a wastewater treatment process of an iron-copper-sulfur polymetallic mine slurry detention reservoir. The step includes the steps of 1,water intaking from the slurry detention reservoir, wherein wastewater can enter a slurry pool through a dirt leading pipe; 2, pretreatment, wherein impurities and sand particles are removed, homogeneity and averaged quantity are achieved, and meanwhile an oxidizing agent is fed to remove reducing substances; 3, preliminary physicochemical treatment, wherein a conditioning agent, coagulant, a heavy metal ion capturing agent and a flocculating agent are added, 4, secondary physicochemical treatment, wherein the conditioning agent, the coagulant, the heavy metal ion capturing agent and the flocculating agent are added, the PH value of wastewater is adjusted to 6.0-11.0, and zinc ions and various remaining metal ions are removed; 5, pH back conditioning; 6, slurry treatment, wherein slurry is dehydrated with a screw pump to form a dry filter cake. By means of the wastewater treatment process, the phenomenon of re-dissolution of heavy metal ions can be avoided; the treatment cost is low, less slurry is generated, and the situation of secondary pollution is avoided.