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The use of Lohan pine fruit polysaccharide

A technology of pine nuts and arhats, which is applied in the field of medical technology and health food to achieve the effect of good safety and tumor shrinkage

Inactive Publication Date: 2020-10-09
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is impossible for professionals in the field to predict whether Podocarpus polysaccharide has anti-liver cancer effect and how effective it is.

Method used

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  • The use of Lohan pine fruit polysaccharide
  • The use of Lohan pine fruit polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 100g of dried Podocarpus pine, put it into a round bottom flask, add water 10 times the actual amount of Podocarpus pine, soak for 30 minutes, heat and extract in a water bath at 80°C for 2 hours, filter, take the filtrate, add 8 times the actual amount of Podocarpus pine to the filter residue A certain amount of water was extracted by heating in a water bath at 80°C for 1 hour, filtered, the filtrates extracted twice were combined, and the volume was recorded, and concentrated under reduced pressure at 80°C until the remaining volume was 5% of the initial volume, and absolute ethanol was added to the concentrated solution to the final volume. The final concentration is 90%, precipitate for 24 hours, centrifuge with a centrifuge at a speed of 4000 rpm for 30 minutes, remove the supernatant, take the precipitate, add 5 times the amount of water to dissolve the precipitate, place it in a separatory funnel, and The mixed solvent composed of n-butanol and chloroform in ...

Embodiment 2

[0023] Take 300g of podocarpus fresh fruit, put it into a round bottom flask, add 7 times the amount of water of Podocarpus solid mass, heat and extract in a water bath at 80°C for 1 hour, filter, take the filtrate, add water 6 times the solid mass of Podocarpus cypress to the filter residue , heated and extracted in a water bath at 80°C for 1 hour, filtered, combined the filtrates extracted twice, recorded the volume, concentrated under reduced pressure at 80°C until the remaining volume was 10% of the initial volume, and added absolute ethanol to the concentrated solution to a final concentration of 85%, precipitated for 48 hours, centrifuged with a centrifuge at a speed of 3500 rpm for 30 minutes, removed the supernatant, took the precipitate, added 7 times the amount of water to dissolve the precipitate, placed it in a separatory funnel, and mixed it with n-butanol and The mixed solvent composed of chloroform at a volume ratio of 1:5 was used as the extractant to extract 5 ...

Embodiment 3

[0025] Take 100g of dried Podocarpus pine, put it into a round bottom flask, add 8 times the actual amount of Podocarpus pine, soak for 30 minutes, heat and extract in a water bath at 100°C for 1.5 hours, filter, take the filtrate, add 6 times the actual amount of Podocarpus pine to the filter residue A certain amount of water was heated and extracted in a water bath at 100°C for 1 hour, filtered, the filtrates extracted twice were combined, the volume was recorded, and concentrated under reduced pressure at 80°C until the remaining volume was 8% of the initial volume, and absolute ethanol was added to the concentrated solution to the final volume. The concentration is 90%, precipitate for 48 hours, centrifuge at a speed of 3000 rpm for 30 minutes with a centrifuge, remove the supernatant, take the precipitate, add 8 times the amount of water to dissolve the precipitate, place it in a separatory funnel, and The mixed solvent composed of n-butanol and chloroform in a volume rati...

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Abstract

The present invention relates to application of Podocarpus macrophyllus fruit polysaccharide in preparation of a medicament for preventing and treating liver cancer or a health food. The Podocarpus macrophyllus fruit polysaccharide is obtained by taking fruits of Podocarpus plants in Podocarpaceae, that is, Podocarpus macrophyllus(Thunb.)D. Don or Podocarpus macrophyllus(Thunb.)D. Don var. maki(Sieb.)Endl. as raw materials, and conducting water extraction, protein removal and column chromatography purification. The Podocarpus macrophyllus fruit polysaccharide has a significant inhibitory effect on tumor growth of liver cancer-bearing mice. The Podocarpus macrophyllus fruit polysaccharide can be made into capsules, oral liquids or granules after appropriate pharmaceutical adjuvants in a certain proportion are added. When used in prevention and treatment of liver cancer, the Podocarpus macrophyllus fruit polysaccharide has no toxic and side effects such as nausea, vomiting, alopecia andmyelosuppression and other common effects in cytotoxic antitumor drug, and is a purely natural safe effective plant polysaccharide.

Description

technical field [0001] The invention belongs to the field of medical technology and health food, and specifically relates to the use of podocarpus polysaccharide in the preparation of medicine or health food for preventing and treating liver cancer. Background technique [0002] Podocarpus macrophyllus (Thunb.) D.Don or Podocarpus macrophyllus (Thunb.) D.Don var .maki (Sieb.) Endl. fruit extraction, isolation and purification. Podocarpus is mainly distributed in Guangxi, Jiangsu, Fujian, Taiwan, Zhejiang and other places in my country. It has been planted on a large scale in Beihai City, Guangxi, with a planting area of ​​more than 10,000 mu, and a large amount of Podocarpus is produced every year. Podocarpus fruit is the fruit of Podocarpus, which consists of a receptacle and seeds. In the place where Podocarpus is planted, the receptacle of Podocarpus can be eaten directly as fruit, or made into fruit wine for drinking; the seeds are mainly used for breeding. At present...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P35/00A23L33/105
CPCA23L33/105A23V2002/00A61K31/715A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P35/00A23V2200/308A23V2250/50
Inventor 黄增琼曾凡艳林乐珍
Owner GUANGXI MEDICAL UNIVERSITY
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