The invention discloses a high-efficiency slow-release fertilizer for high-efficiency cultivation of coix seeds in saline land. The high-efficiency slow-release fertilizer is prepared from, by weight, oyster shells, polylactic acid, activated nano attapulgite, viscid loess, almond residues, tea waste residues, rice chaff ash, modified sea mud, perlite, vermiculite powder, VA mycorrhiza, saccharomycetes, exogenous proline, ardealite, a proper amount of hydrogen peroxide, a proper amount of ammonia water and the like. The almond residues, the tea waste residues, the rice chaff ash, the modified sea mud, the perlite, the vermiculite powder and the like are matched with nutrient substances to prepare the coated slow-release fertilizer after fermentation, and the fertilizer contains rich fermented micromolecular organic matter, the inorganic moisture regulator vermiculite powder and the like itself, is easily absorbed and utilized by plants. In addition, the pH value of saline and alkaline land is automatically regulated by adopting the inorganic moisture regulator, and the resistance of the coix seeds in the saline land is improved. A coating layer capable of supplying oxygen and dynamically regulating pores is adopted, the fertilizer efficiency time is long, organic matter nutrients can be released for a long time, high-efficiency cultivation of the coix seeds in the saline land is promoted, and the high-efficiency slow-release fertilizer can be widely applied and popularized.