Whitening liquid crystal composition as well as preparation method and application thereof

A liquid crystal composition and whitening technology, which can be applied in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of insufficient whitening effect, single effect, skin irritation, etc., and achieve effective penetration promotion, good stability, and improved The effect of load

Active Publication Date: 2018-08-28
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the problems of whitening products in the prior art with single effect, poor stability, insufficient whitening effect, and easy skin irritation, the present invention provides a whitening liquid crystal composition, which can be loaded with high-concentration whitening ingredients, and effectively controls the slow-down of the whitening active ingredients. Release, promote skin penetration, reduce irritation and improve whitening effect

Method used

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  • Whitening liquid crystal composition as well as preparation method and application thereof
  • Whitening liquid crystal composition as well as preparation method and application thereof
  • Whitening liquid crystal composition as well as preparation method and application thereof

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preparation example Construction

[0083] The present invention also provides a preparation method of the whitening liquid crystal composition described in the above technical solution, comprising the following steps:

[0084] A. Dissolving liquid crystal emulsifier and non-water-soluble whitening active ingredient in liquid lipid to obtain oil phase;

[0085] B. Dissolving co-emulsifier and emulsification thickener in water to obtain water phase;

[0086] C. Dissolving the water-soluble whitening active ingredient in water to obtain an aqueous solution of the whitening active ingredient;

[0087] D. Mix and emulsify the oil phase obtained in step A with the water phase obtained in step B, and micronize it to obtain a micron-scale dispersion;

[0088] E. Mix and emulsify the aqueous solution of whitening active ingredients obtained in step C with the micron-sized dispersion obtained in step D, and perform nano-processing to obtain a whitening liquid crystal composition;

[0089] There is no sequence limitatio...

Embodiment 1

[0107] In terms of mass percentage, 1.0% soybean lecithin, 2.0% cetearyl alcohol (and) cocoyl glucoside, 4.0% isopropyl palmitate, 2.0% isopropyl myristate and 2% glabridin Melt in a water bath at 70°C to obtain an oil phase for later use;

[0108] Mix 0.1% ferulic acid, 0.1% arbutin, 1.0% nicotinamide, 0.1% VC and its derivatives, 1.0% glycyrrhizinic acid, 5.0% tea polyphenols and 30% water, under the condition of 35 ℃ water bath Stir to obtain the whitening active ingredient aqueous solution, and set aside;

[0109] Dissolve 2.0% polyethylene glycol, 3.0% hexanediol and 0.01% hydroxyethyl acrylate into 46.6% water, stir in a water bath at 70°C to obtain a water phase, and set aside;

[0110] Mix the water phase with the oil phase, and after the mixing is completed, high-speed shear emulsification for 5 minutes at a rotation speed of 5500 rpm to obtain a micron-sized dispersion;

[0111] The micron-scale dispersion is mixed with the whitening active ingredient aqueous solut...

Embodiment 2

[0113] In terms of mass percentage, 0.5% hydrogenated lecithin, 0.5% hydroxystearyl alcohol and hydroxystearoside, 2.0% caprylic capric triglyceride, 2.0% propylene glycol dioctylcaprate and 1.0% VE were placed in a water bath at 65°C Melt down to get the oil phase, set aside;

[0114] Mix 3.0% α-arbutin, 3.0% nicotinamide, 1.0% vitamin C ethyl ether, 2.0% silymarin with 35% water, stir in a water bath at 40°C to obtain an aqueous solution of whitening active ingredients, and set aside;

[0115] 2.0% stearyl alcohol, 3.0% hexanediol, 2.0% sodium acrylate / sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80 and 3.0% Dissolve the bohm in 35% water, stir in a water bath at 65°C to obtain the water phase, and set aside;

[0116] Mix the water phase and the oil phase, and after the mixing is completed, high-speed shear emulsification for 1 min at a rotation speed of 5000 rpm to obtain a micron-sized dispersion;

[0117] Mix the micron-scale dispersio...

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Abstract

The invention relates to the field of cosmetics and provides a whitening liquid crystal composition. The whitening liquid crystal composition is prepared from whitening active ingredients and liquid crystal carriers, wherein the whitening active ingredients are prepared from at least two of an active ingredient for promoting exfoliation, a tyrosinase inhibitor, an active ingredient for inhibitingmelanosome migration, an antioxidant active ingredient, an anti-inflammation active ingredient and an anti-glycation active ingredient; the liquid crystal carriers are prepared from the following rawmaterials: a liquid crystal emulsifying agent, a co-emulsifier and an emulsification thickening agent; the whitening liquid crystal composition is also prepared from liquid-state lipide for dissolvingthe whitening active ingredients and the liquid carrier raw materials as well as water. According to the whitening liquid crystal composition, through compounding of different whitening mechanisms and load of the liquid crystal carriers, an obvious synergetic effect is achieved, the stability and the whitening effect of the whitening liquid crystal composition can be obviously improved, and meanwhile, the problem of skin irritation easily caused by the load of the whitening active ingredients with high concentration is solved.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a whitening liquid crystal composition and a preparation method and application thereof. Background technique [0002] Healthy and fair skin is the focus of most women's attention. Oriental women have always advocated the whitening effect of "skin like snow, condensed like fat". However, the current whitening skin care products on the market generally have the following problems: [0003] 1. Single whitening mechanism: most products only target one melanin formation and transfer mechanism, and cannot achieve full-effect whitening; [0004] 2. Poor product stability: When making most whitening products on the market, whitening ingredients are directly added to the formula, which can easily lead to discoloration and odor change of the product, and even layering and thickening of the paste; [0005] 3. Low whitening efficiency: Due to the skin's own barrier, it is difficult for whitening ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/67A61K8/63A61K8/60A61K8/55A61K8/49A61K8/365A61K8/02A61Q19/00A61Q19/02
CPCA61K8/0295A61K8/365A61K8/498A61K8/553A61K8/602A61K8/63A61K8/675A61K8/676A61K8/9789A61K2800/782A61Q19/00A61Q19/02
Inventor 刘卫洪延涵闻庆卞思静韩非郭赛红
Owner WUHAN BEST CARRIER NANO TECH
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