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Polypeptide composition for skin whitening and spot relieving

A polypeptide composition and the technology of the composition are applied in the directions of drug combinations, preparations for skin care, tetrapeptide components, etc., which can solve the problems of not recommending long-term use, good light absorption, and unstable vitamin C.

Active Publication Date: 2016-03-02
宇肽生物(东莞)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, vitamin C is unstable and difficult to be absorbed by the skin, so it is difficult to be widely used; arbutin is a compound containing phenolic groups. Although it is safe, it has a slow inhibitory effect on tyrosinase and has good light absorption, so it is not suitable for daytime use. Use; kojic acid is the most obvious ingredient in whitening and freckle removal. It is extracted from the fermentation broth of Aspergillus and Penicillium. It contains certain toxicity and is not recommended for long-term use; Chinese medicine extracts still need to be tested for efficacy. More in-depth research; phenylethylresorcinol is a compound discovered in recent years, and its inhibitory effect on tyrosinase activity is stronger than kojic acid / arbutin
[0005] Most of the whitening products on the market are tyrosinase inhibitors, and the production of melanin is very complicated, and the effect of lightening and whitening is not very satisfactory

Method used

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  • Polypeptide composition for skin whitening and spot relieving
  • Polypeptide composition for skin whitening and spot relieving
  • Polypeptide composition for skin whitening and spot relieving

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Whitening Serum

[0038] Prescription (1kg of serum):

[0039]

[0040] Configuration method:

[0041] Add the prescribed amount of sodium hyaluronate to the water, stir to mix evenly, then heat to 80-85°C, keep stirring for uniform dispersion. When the temperature drops below 40°C, add glycerin, aloe vera gel, nonapeptide-1, decapeptide-12, phenethyl resorcinol, sodium hyaluronate, caprylyl glycol and 1,2-hexanediol, and stir evenly. Adjust the pH of the solution to about 5.5 with 15% triethanolamine.

Embodiment 2

[0043] Prescription (1kg of serum):

[0044]

[0045]

[0046] Configuration method:

[0047] Add the prescribed amount of sodium hyaluronate to the water, stir to mix evenly, then heat to 80-85°C, keep stirring for uniform dispersion. When the temperature drops below 40°C, add glycerin, aloe vera gel, nonapeptide-1, tetrapeptide-27, phenethyl resorcinol, sodium hyaluronate, caprylyl glycol and 1,2-hexanediol, and stir evenly. Adjust the pH of the solution to about 5.5 with 15% triethanolamine.

Embodiment 3

[0049] Prescription (1kg of serum):

[0050]

[0051] Configuration method:

[0052] Add the prescribed amount of sodium hyaluronate to the water, stir to mix evenly, then heat to 80-85°C, keep stirring for uniform dispersion. When the temperature drops below 40℃, add glycerin, aloe vera gel, nonapeptide-1, tetrapeptide-27, oligopeptide-68, phenethyl resorcinol, sodium hyaluronate, caprylyl glycol and 1,2-hexanediol alcohol, mix well. Adjust the pH of the solution to about 5.5 with 15% triethanolamine.

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Abstract

The invention provides a polypeptide composition for skin whitening and spot relieving. The polypeptide composition comprises an MC1-R antagonist (namely an alpha-MSH competitive antagonist) and / or a composition of polypeptides inhibiting alpha-MSH expression and / or a tyrosinase inhibitor. The polypeptide composition can reduce the generation of melanin, and contributes to skin brightening, so as to achieve the purposes of relieving color spots (chloasma, butterfly rash, freckle and the like), improving sallow tone and whitening skin. The concentration of each polypeptide is 0.0001-5%. The polypeptide composition provided by the invention can be prepared into various beauty and skin-care products as well as medical products.

Description

technical field [0001] The invention belongs to the field of medicine and cosmetic products, and relates to a polypeptide composition for whitening, brightening and lightening spots. Various dosage forms including creams, essences, emulsions, freeze-dried powders, facial masks, etc. are prepared by the method of compounding active polypeptides. For the treatment of pigmentation (melasma, mottled spots and freckles, etc.), in order to achieve the purpose of improving dullness and whitening the skin. Background technique [0002] The following description contains background information that may be useful in understanding the present invention. However, it is not an admission that any information provided herein is prior art to the presently claimed invention or related applications, nor is it an admission that any specific or implied reference is made to the disclosed prior art. [0003] Melanin has the greatest impact on skin color, and the route of formation in the skin is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K45/06A61K38/07A61K38/08A61Q19/02A61Q19/00A61P17/00A61L15/32
CPCA61K8/64A61K38/07A61K38/08A61K45/06A61K2800/782A61L15/32A61Q19/00A61Q19/005A61Q19/02A61K2300/00
Inventor 丁文锋
Owner 宇肽生物(东莞)有限公司
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