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Alpha-arbutin co-conveying nanometer composition and preparation method and application thereof

A nano-composite, arbutin technology, applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of poor α-arbutin transdermal performance, insufficient whitening effect, poor stability and the like , to achieve the effect of improving skin retention, increasing drug loading and structural stability

Active Publication Date: 2018-11-02
WUHAN BEST CARRIER NANO TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the problems of poor transdermal performance, poor stability and insufficient whitening effect of α-arbutin in the prior art, the present invention provides a co-delivery nano composition of α-arbutin with high drug loading capacity, α-Arbutin and other effective substances have high skin permeability and high retention. The compounding of multi-target and multi-mechanism whitening active ingredients combined with nano drug carrier coating can significantly improve the whitening effect, high stability, and no significant effect on the skin. irritant

Method used

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  • Alpha-arbutin co-conveying nanometer composition and preparation method and application thereof
  • Alpha-arbutin co-conveying nanometer composition and preparation method and application thereof

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preparation example Construction

[0090] The present invention also provides a method for preparing the α-arbutin co-delivery nano composition described in the above technical solution, comprising the following steps:

[0091] A. Dissolving α-arbutin, other water-insoluble whitening active ingredients, emulsifiers, and co-emulsifiers in oil to obtain an oil phase;

[0092] B. Dissolving other water-soluble whitening active ingredients with water to obtain an aqueous phase;

[0093] C. Mix and emulsify the oil phase obtained in step A with the water phase obtained in step B, and micronize to obtain a micron-scale dispersion;

[0094] D, the micron-scale dispersion obtained in step C is subjected to nano-processing to obtain a nano-scale dispersion, which is a co-delivery nano composition of α-arbutin;

[0095] There is no sequence between the steps A and B.

[0096] According to the water solubility of other whitening active ingredients, the present invention is divided into water-soluble other whitening acti...

Embodiment 1

[0115] 0.01% glabridin, 5% vitamin E, 0.01% glycyrrhetinic acid, 0.1% carnosine, 25.0% polyoxyethylene sorbitan fatty acid ester, 7.0% sorbitan fatty acid ester, 5.0% polyoxyethylene Sorbitan fatty acid ester, 5.0% isopropyl myristate, 0.5% glyceryl laurate, 2.0% palmityl palmitate, 7.0% polyethylene glycol 400 and 8.0% propylene glycol were mixed and stirred in a water bath at 65°C , to obtain the oil phase and set aside;

[0116] Add 5.0% α-arbutin, 8.0% nicotinamide, and 2.0% vitamin C ethyl ether into 20.38% water, mix well in a water bath at 65°C to obtain a water phase, and set aside;

[0117] Add the oil phase solution to the water phase dropwise at a rate of 3 drops / second, and stir evenly at 65°C. After the dropwise addition, high-speed shear emulsification at 10,000 rpm for 1 min to produce a micron-sized dispersion of 2.8 μm;

[0118] The micron-scale dispersion is subjected to high-pressure homogenization treatment under the condition of a pressure of 1200 bar, an...

Embodiment 2

[0121] 3.0% phenylethyl resorcinol, 0.01% vitamin C tetraisopalmitate, 0.05% dipotassium glycyrrhizinate, 0.5% phloretin, 10.0% sorbitan fatty acid ester, 15.0% polyoxyethylene Sorbitan fatty acid ester, 13.0% polyoxyethylene fatty acid ester, 2.0% glyceryl laurate, 1.0% palmityl palmitate, 2.0% isopropyl palmitate, 13.0% propylene glycol, 5.0% glycerin and 1.0% 1, Mix and stir 3-butanediol in a water bath at 65°C to obtain an oil phase, which is set aside;

[0122] Add 0.05% α-arbutin, 17.0% nicotinamide, and 3.0% vitamin C glucoside into 14.39% water, mix well in a water bath at 65°C to obtain a water phase, and set aside;

[0123] Add the oil phase solution to the water phase dropwise at a rate of 3 drops / second, and stir evenly at 65°C. After the dropwise addition, high-speed shear emulsification at 8000rpm for 3min to make a micron-sized dispersion of 8.9μm;

[0124] The micron-scale dispersion is subjected to high-pressure homogenization treatment under the condition of...

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Abstract

The invention relates to the field of cosmetics and provides an alpha-arbutin co-conveying nanometer composition. The alpha-arbutin co-conveying nanometer composition comprises alpha-arbutin, other skin-whitening active components and a nanometer medicine carrier; the alpha-arbutin accounts for 0.05 to 20.0 percent of the total mass of the co-conveying nanometer composition; other skin-whitening active components comprise at least one of a tyrosinase inhibitor outside the alpha-arbutin, a melanosomal migration inhibitor, an antioxidant, an anti-glycation active substance and an anti-inflammatory agent; the raw materials of the nanometer medicine carrier comprise an emulsifier and a co-emulsifier; and the alpha-arbutin co-conveying nanometer compositionl also comprises grease and water. Remarkable synergistic effect is achieved through compounding of different skin-whitening mechanisms and loading of the nanometer medicine carrier; the melanin content of skin is obviously reduced through multi-target-point effect; and the co-conveying nanometer composition can realize sustained release and controlled release of medicines, has large medicine carrying quantity, high stability, high water solubility, high skin permeability and excellent skin-whitening effect, and can be widely applied to cosmetics.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to an α-arbutin co-delivery nanocomposition and its preparation method and application. Background technique [0002] Healthy and fair skin is the focus of most women's attention. Oriental women have always advocated the whitening effect of "skin like snow, condensed like fat". However, the current whitening skin care products on the market generally have the following problems: [0003] 1. Single whitening mechanism: most products only target one melanin formation and transfer mechanism, and cannot achieve full-effect whitening; [0004] 2. Poor product stability: When making most whitening products on the market, whitening ingredients are directly added to the formula, which can easily lead to discoloration and odor change of the product, and even layering and thickening of the paste; [0005] 3. Low whitening efficiency: Due to the skin's own barrier, it is difficult for whitening acti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60A61K8/34A61K8/35A61K8/36A61K8/49A61K8/63A61K8/67A61K8/73A61K8/9789A61Q19/02
CPCA61K8/34A61K8/347A61K8/35A61K8/36A61K8/4946A61K8/498A61K8/4986A61K8/602A61K8/63A61K8/671A61K8/673A61K8/676A61K8/678A61K8/73A61K8/735A61K2800/412A61K2800/413A61K2800/782A61Q19/02A61K8/9789
Inventor 刘卫吴航航吴培诚陈家铃闻庆
Owner WUHAN BEST CARRIER NANO TECH
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