Soluble microneedle patch used for skin whitening and preparation method thereof

A soluble, microneedle patch technology, applied in the field of skin care products, can solve the problems of piercing the stratum corneum, poor mechanical strength of soluble microneedles, etc., and achieve the effects of lightening pigmentation, favorable for microneedle molding, and good mechanical strength.

Active Publication Date: 2017-11-24
GUANGZHOU NEWORLD PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical strength of soluble microneedles prepared by some cosmetic active ingredients and hyaluronic acid is poor, which is not enough to effectively pierce the stratum corneum to generate micropores for drug delivery. A major problem in the development of injection preparations

Method used

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  • Soluble microneedle patch used for skin whitening and preparation method thereof
  • Soluble microneedle patch used for skin whitening and preparation method thereof
  • Soluble microneedle patch used for skin whitening and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Dissolvable microneedle patches for whitening prepared with different prescriptions, the formulations of each raw material are shown in Table 1:

[0048] The raw material formula of table 1 dissolvable microneedle patch

[0049]

[0050] Note: HA refers to hyaluronic acid with a molecular weight of 2000kDa.

[0051] The preparation method is as follows:

[0052]According to the raw materials and their proportions shown in Table 1, weigh an appropriate amount of each raw material and place it in a 10ml centrifuge tube, use purified water 2.5 times the total mass of raw materials as a solvent, vortex to mix and dissolve, and prepare 8 kinds of needle tip solutions according to the prescription in Table 1. . Use a syringe to draw the needle tip liquid into the microneedle mold, inject 500 μl of the needle tip liquid into each piece, spread it flat, and centrifuge it in a refrigerated centrifuge (at a temperature of 4°C) at 3000 rpm for 2 minutes, absorb the excess nee...

Embodiment 2

[0054] The hardness and ductility of the 8 whitening dissolvable microneedle patches prepared in Example 1 were tested.

[0055] Place the needle tip of the microneedle patch upward on the horizontal test platform, pass through the P / 6 flat-head stainless steel cylindrical probe, at a stable speed of 0.1mm / sec, with an excitation force of 0.05N, apply an axial vertical force, and set the measurement parameters As in Table 2. The analyzer records the mechanical changes during the probe contact with the needle tip until reaching the preset height (microneedle height 400 μm).

[0056] Table 2 Test parameters

[0057]

[0058] After the test is completed, take out the tested microneedle samples on the stage, and use a microscope to observe the local morphology changes of the microneedles after the force applied by the texture analyzer probe.

[0059] Table 3 shows the results of testing the hardness and ductility of microneedles prepared by different formulations using textur...

Embodiment 3

[0071] The solubility determination of embodiment 3 dissolvable microneedle patch

[0072] Precisely weigh gelatin of different qualities, purified water, and sucrose according to the proportions in Table 4, place in a 50ml centrifuge tube, dissolve overnight in a water bath at 90°C, centrifuge, degas, quickly transfer to a transparent petri dish, cool, and solidify into gelatin sucrose gels with different water contents.

[0073] Table 4 Gelatin Gel Composition

[0074]

[0075] The 8 kinds of soluble microneedle patches prepared in Example 1 were inserted into the surface of the gel along the edge of the petri dish, observed from the side with an electron microscope at different time points, and recorded the dissolution conditions at different time points until no visible microneedles were observed. The needle body was used as the end point of dissolution, and the microneedle was taken out for further observation under a microscope to confirm the dissolution time point. ...

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Abstract

The invention relates to a soluble microneedle patch used for skin whitening and a preparation method thereof. The soluble microneedle patch comprises a needle point and a substrate, the needle point comprises the following raw materials in parts by weight: 1 part of arbutin, 15-30 parts of hyaluronic acid or its salt, and 5-25 parts of a forming material; wherein the hyaluronic acid or its salt is hyaluronic acid or sodium hyaluronate; and the forming material is selected from at least one of fructose, mannose, carboxymethylcellulose sodium and hydroxypropyl methylcellulose. The soluble microneedle patch has good mechanical strength, hardness and dissolvability, avoids the disadvantage that a traditional skin-caring mode cannot perform arbutin advantage, and has obvious effects for lightning color spots and whitening skin.

Description

technical field [0001] The invention relates to the field of skin care products, in particular to a whitening dissolvable microneedle patch and a preparation method thereof. Background technique [0002] Microneedle transdermal drug delivery technology is a new drug delivery method developed under the conditions of micro-electromechanical system processing technology and transdermal penetration enhancement technology. Microneedle arrays have the advantages of small size, high strength, precise control of puncture position and depth, and painless puncture. They can be used for transdermal drug delivery of chemical drugs, proteins, vaccines, etc., and have great development prospects. Microneedle technology has not only been widely used in the field of biomedicine, but also received unprecedented enthusiasm in the field of beauty. Microneedle beauty has been widely used in Europe, America, Japan, South Korea and other places. Microneedle has a wide range of uses in the field ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/60A61Q19/02
CPCA61K8/602A61K8/731A61K8/735A61K2800/782A61K2800/91A61Q19/02
Inventor 陈航平李革郑腾羿
Owner GUANGZHOU NEWORLD PHARMA CO LTD
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