205 results about "Methylamines" patented technology

The invention discloses a carbon fiber modified sizing agent as well as a preparation method and application thereof. The preparation method of the carbon fiber modified sizing agent comprises the following steps: (1) reacting 5-norbornene-2-methylamine with monofunctional epoxy resin to obtain slurry; and (2) dissolving the slurry prepared in the step (1) in an organic solvent to prepare the modified sizing agent. And then obtaining the modified carbon fiber through a dipping and sizing process. The method is simple in process, and the interface bonding strength of the carbon fibers and the polydicyclopentadiene can be greatly improved.

The invention discloses heat-resistant polymethyl methacrylate, a preparation method thereof and an optical film. The heat-resistant polymethyl methacrylate comprises a methyl methacrylate repetitive unit, a glutarimide repetitive unit and an N-methyl methacrylamide repetitive unit, and the sum of the number of the glutarimide constitutional unit and the number of the N-methyl methacrylamide constitutional unit is 1-20 mol% of the total number of the constitutional units. The glutarimide structural unit can be obtained by further cyclization reaction of an N-methyl methacrylamide structural unit, and the cyclization rate can be increased to 80-90% by adding a cyclization accelerator such as triethylamine, so that the thermal stability of the resin is improved, and the water absorption rate is reduced. The material can be used for preparing an optical film, has excellent heat resistance and moisture resistance, and is suitable for the field of optical display.

The invention relates to the field of agricultural bactericides, in particular to a suspending agent containing fenaminstrobin and validamycin A and application of the suspending agent. The bactericidal composition comprises a suspending agent containing fenaminstrobin and validamycin A, an active component, a stabilizer, an auxiliary agent and water, the active component accounts for 1-70% of the mass of the preparation, and the stabilizer accounts for 0.1-10% of the mass of the preparation; wherein the active ingredients are fenaminstrobin and validamycin A, and the stabilizer is meglumine (N-methyl-D-glucosamine). The suspending agent prepared by the technical scheme of the invention effectively inhibits the increase of the particle size of a sample in the thermal storage process of a preparation, effectively improves the suspension rate of fenaminstrobin after the thermal storage of the preparation, improves the utilization rate of a pesticide, and ensures the normal exertion of the efficacy of the pesticide at the same time. Meanwhile, the quality of the active components of the stabilizer-containing bactericide is stable within the shelf life, the addition of the stabilizer does not cause the decomposition of the active components, and the preparation does not have obvious physical or chemical change.

The application discloses a continuous system and method for converting low-value glyphosate by-products into high-value chemical products, comprising: pumping low-value glyphosate by-products and alkaline compounds into a constant-temperature conversion kettle for conversion and decomposition, and introducing nitrogen into the top of the constant-temperature conversion kettle to blow off and replace gaseous volatile products generated in the reaction; after gaseous products pass through a buffer tank to capture water vapor, the gaseous products enter a three-stage condenser to recover condensable components into a crude product receiving tank, and the non-condensable components are purified and impurities are removed by an acid absorption system and then utilized; liquid crude product is pumped into a low-temperature vacuum desolventizing kettle to realize separation of condensable components from liquid water, and then enters a two-stage condenser for deep dehydration and separation, and is recovered into a pure product receiving tank. The application realizes a new process for preparing high-purity N,N-diethylmethylamine, and forms a whole-process process system for converting low-value waste materials such as chloromethane, triethylamine and synthetic products thereof into high-value chemical products such as N,N-diethylmethylamine and ethylene.

The present application relates to a kind of catalyst composition and its application in catalytic preparation optically active secondary alcohol, the catalyst composition includes chiral ionic bridged aryloxyalkane rare earth complex and additive, the additive is selected from one or more of pyrimidine, N,N-dicyclohexylmethylamine, 4,4'-dipyridyl.The above-mentioned catalyst composition can be used for synergistically catalyzing asymmetric borohydration of chalcone and its derivatives with pinacol borane, and show high catalytic activity and high enantioselectivity, product yield is as high as 99%, ee value can reach 84%, provide a reliable new way for the efficient, high selective synthesis of optically active secondary alcohol.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

The invention discloses a highly-oriented quasi-two-dimensional perovskite multi-wafer scintillator for X-ray detection imaging and a preparation method of the highly-oriented quasi-two-dimensional perovskite multi-wafer scintillator, and relates to the technical field of radiation detection and scintillation materials, the highly-oriented quasi-two-dimensional perovskite multi-wafer scintillator comprises phenethyl ammonium bromide, cesium lead tribromide and ammonium thiocyanate, the molar ratio of the phenethyl ammonium bromide to the cesium lead tribromide to the ammonium thiocyanate is 2: 4: 2, the scintillator contains a methylamine thiocyanate additive which accounts for 0-1 equivalent weight of the dosage of the ammonium thiocyanate, and the scintillator is of a flaky polycrystal structure; the perovskite crystal of the polycrystalline wafer has a quasi-two-dimensional layered crystal structure, and each crystal grain is arranged in a height orientation manner, so that the layered crystal face is parallel to the main plane of the scintillator sheet. According to the highly-oriented quasi-two-dimensional perovskite multi-wafer scintillator for X-ray detection imaging and the preparation method of the highly-oriented quasi-two-dimensional perovskite multi-wafer scintillator, a highly-oriented layered structure is formed in the crystal, diffuse scattering of emergent light is greatly reduced, brightness uniformity and spatial resolution of X-ray imaging are improved, and a finer imaging effect is achieved.

This invention provides a continuous method for preparing high-purity creatine monohydrate, comprising the following steps: a) adding chloroacetic acid aqueous solution dropwise to an aqueous methylamine solution, stirring at room temperature for 2 hours after the addition is complete; b) heating to 50-60°C and holding for 1 hour to remove most of the methylamine, then heating to 95°C to evaporate the methylamine aqueous solution for 1 hour; c) adding sodium hydroxide solution dropwise to the solution from step b) at 95°C, then heating to 105°C and concentrating under reduced pressure for 1.5 hours to approximately half the original volume, obtaining a creatine solution with a concentration of 30%-40%; d) cooling the solution from step c) to 40-60°C and adding a catalyst; e) drying to obtain pure creatine monohydrate. This invention reduces the methylamine equivalent, saving costs, and eliminates the need for purifying creatine for direct use in the next reaction; it can simultaneously lower the system reaction temperature and pH value to inhibit the formation of byproducts dicyandiamide and creatinine, and eliminates the need for debittering agents for purification and debittering, thus saving production costs.

The subject of the invention is N-substituted derivatives of l-(l-phenyl-3-aryl)-lH-pyrazol-4-yl)methanamine with the general formula 1, where ¥ represents CH or N, R1 represents hydrogen, R2 represents no substituent, R3 represents hydrogen, while R4 represents N-propylbenzamide, benzo[b]furan, dihydrobenzo [b] furan, methylenedioxybenzene, ethyl benzoate, or propyl benzoate, substituted accordingly, their method of production and application, and the method of obtaining and application of N-substituted derivatives of l-(l-phenyl-3-aryl)-IH-pyrazol-4-yl)methanamine with the general formula 1, where Y represents C, CH, or N, R1 represents hydrogen or a methyl group, R2 represents a methyl group or no substituent, R3 represents hydrogen or a methyl group, while R4 represents dimethylpyrazole, methylpyrazole, dimethylimidazo[l,2-a]pyrimidine, or isopropoxybenzene, substituted accordingly. The compounds that are the subject of the invention are obtained through reductive amination using borohydride derivatives as the reducing agent, advantageously sodium triacetoxyborohydride, in the amount of 1.4-2.0 eq, amine in the amount of 1.0-1.1 eq, advantageously in slight excess, base, advantageously triethylamine in the amount of 1.0-1.1 eq (in the case of using amine in the form of hydrochloride), and the starting aldehyde. The reaction is conducted in a nonpolar solvent environment, advantageously dichloroethane at a concentration of about 0.1 M. The crude product is purified by column chromatography on silica gel using a methanol in dichloromethane mixture as the eluent, in concentration ranges from 2% to 5%. In order to obtain a solid form and improve the physicochemical parameters, the free bases are converted into hydrochloride form, and then crystallized from a polar solvent, advantageously ethanol or propanol.

The invention discloses a preparation method of a high-quality perovskite thick film for an X-ray detector, and relates to the technical field of radiation detection materials and devices. The preparation method of the thick film comprises the following steps: preparing a precursor solution from lead iodide, cesium iodide, formamidine iodide, methylamine iodide, 4-guanidinobenzoic acid hydrochloride, N, N-dimethylformamide and acetonitrile; a bulk phase functional additive is introduced to optimize a large number of Schottky defects at the grain boundary of the perovskite thick film; depositing onto a heated conductive glass substrate using a spray coating technique; and in combination with a low-temperature solvent atmosphere annealing process, secondary growth of crystal grains and grain boundary healing are promoted, and a large-area polycrystalline thick film can be obtained.

The application belongs to the technical field of organic synthesis, and discloses a preparation method of N-ethyl-2-(N-methyl pyrrolyl) pyrrole, which comprises the following steps: dissolving 1-furfuryl pyrrole, ethylamine and ethanol in water, adding hydrochloric acid into the water, heating and reacting, the reaction temperature is 150-180 DEG C, and the reaction time is 15-35 h; and the target product is obtained. The 1-furfuryl pyrrole is prepared by condensation reaction of 2-furfurylamine and 2,5-dimethoxy tetrahydrofuran, and then the target product N-ethyl-2-(N-methyl pyrrolyl) pyrrole is prepared by reaction of the 1-furfuryl pyrrole and ethylamine, and the raw materials are relatively cheap and have high industrial value.

The invention relates to a preparation method of a metal halide perovskite-coated three-dimensional cobalt porphyrin-based COFs (Covalent Organic Frameworks) composite material, which comprises the following steps: S1, reacting an aldehyde precursor with an amine precursor in a first organic solvent, and after the reaction is finished, performing post-treatment to obtain a three-dimensional cobalt porphyrin-based COFs material; wherein the aldehyde precursor is 5 ', 5 '', 5'' '', 5'' ''''-(5, 10, 15, 20-tetrayl) tetra (([1, 1': 3 ', 1 ''-terphenyl]-4, 4''-diformyl))-21H, 23H-cobalt porphyrin (II), and the amine precursor is 4, 4'-diamino terphenyl and 2 ', 5'-bis ((methylthio) methyl)-[1, 1 ': 4', 1 ''-biphenyl]-4, 4''-diamine; s2, in a second organic solvent, enabling the three-dimensional cobalt porphyrin-based COFs material to react with lead bromide, and after the reaction is finished, performing post-treatment to obtain a PbBr2 (at) 3D Co-COFs material; and S3, in a third organic solvent, carrying out a reaction on the PbBr2 (at) 3D Co-COFs material and methylamine bromide, and after the reaction is finished, carrying out post-treatment to obtain the metal halide perovskite (at) three-dimensional cobalt porphyrin-based COFs composite material. The preparation method has the advantage that the photocatalytic activity and stability are improved.

The present application relates to a kind of preparation methods of 2-methylamino-3-formylpyridine, comprising the following steps: 3-cyanopyridine and dimethyl sulfate are heated to reflux reaction in organic solvent I, then base is added, continue to react under heating reflux condition, and obtain intermediate product 2-methylamino-3-formylpyridine.The raw material used in the preparation method of the present application is cheap and easy to obtain, the preparation process has few side reactions, and is easy to purify.Only the steps of extraction and heavy crystallization are needed to achieve high purity, and strict control of anhydrous reaction conditions is not required.The yield and purity are high, and the prepared 2-methylamino-3-formylpyridine is suitable for industrial large-scale production of 2-methylamino-3-hydroxymethylpyridine, and further preparation of eslicarbazepine acetate and / or eslicarbazepine acetate sulfate.

This invention relates to an isosorbide dinitrate pharmaceutical composition injection and its preparation method. In addition to isosorbide dinitrate, the injection formulation also contains meglumine and glutathione. The preferred specifications are 5ml:5mg and 10ml:10mg. The isosorbide dinitrate injection prepared according to the formulation and process of this invention has the characteristics of high excipient safety, simple process, extremely high quality stability and good safety, which is significantly better than the prior art.

The invention discloses vonoprazan fumarate, intragastric retention tablets of the vonoprazan fumarate and application of the vonoprazan fumarate to gastrointestinal tracts, and relates to the technical field of medicines.The vonoprazan fumarate is prepared through a synthesis method comprising the following steps that in the presence of an organic solvent and alkali, 5-(2-fluorophenyl) pyrrole-3-formaldehyde and pyridine-3-sulfonyl chloride are subjected to a reaction, and the vonoprazan fumarate is obtained. Hydroxypropyl-beta-cyclodextrin is added into a reaction system, and a compound WNLZ-1 is generated; reacting the compound WNLZ-1 with methylamine, and then reducing to obtain a compound WNLZ-3; the compound WNLZ-3 and fumaric acid are subjected to a salt forming reaction, and vonoprazan fumarate is obtained. According to the preparation method, hydroxypropyl-beta-cyclodextrin is introduced as a reaction accelerant in the synthesis step, the yield and purity of an intermediate are improved, meanwhile, hydroxypropyl-beta-cyclodextrin and xanthan gum are jointly used in the preparation, and the whole process optimization from raw material medicine synthesis to preparation performance is achieved.

A composition for carbon dioxide (CO2) capture includes 2-aminocyclohexanol, cis-1,2-diaminocyclohexane, meglumine, or combinations thereof. A process of CO2 capture includes mixing a CO2-containing gas with the composition. A system includes a component for receiving a gas and the composition, which absorbs CO2 from the gas. A further composition includes a first amine solvent selected from 2-aminocyclohexanol, cis-1,2-diaminocyclohexane, and meglumine and a second amine solvent independently selected from 2-aminocyclohexanol, cis-1,2-diaminocyclohexane, meglumine, ethyl diethanolamine, dimethylethanolamine, piperidine, 2-amino-2-methyl-1-propanol, and monoethanolamine. A further process includes reacting CO2 with an amine selected from 2-aminocyclohexanol, cis-1,2-diaminocyclohexane, and meglumine.

The solvated metal particle-coating system includes a metal additive and a polar outer-sphere electron transferring solvent. The metal additive is solvated in the polar outer-sphere electron transferring solvent. The polar outer-sphere electron transferring solvent may include liquid ammonia, methylamine, and / or hexamethylphosphoramide. The metal additive may include an alkali metal and / or an alkaline earth metal. The solvated metal additive within the polar outer-sphere electron transferring solvent may be used to coat a metal particle and / or a metalloid particle as a layer. As the polar outer-sphere electron transferring solvent evaporates, the solvated metal additive is coupled to the metal particle and / or the metalloid particle.

The invention belongs to the technical field of organic synthesis, and particularly provides a preparation method of (trimethylsilyl) methylamine hydrochloride. The preparation method provided by the embodiment of the invention comprises the following steps: carrying out reduction reaction on N-[(trimethylsilyl) methyl] benzylamine, and salifying with hydrochloric acid to generate (trimethylsilyl) methylamine hydrochloride. According to the preparation method disclosed by the embodiment of the invention, milder reduction hydrogenation operation is selected, severe conditions such as high temperature and high pressure are avoided, and the reaction yield and the product purity are improved.

The invention discloses a methylamine-free perovskite thin film with high thermal stability and a preparation method of the methylamine-free perovskite thin film. The perovskite thin film is prepared from an FAPbI3 perovskite precursor solution doped with 2-(methylsulfonyl) ethylamine hydrochloride. A proper amount of 2-(methylsulfonyl) ethylamine hydrochloride is added into the perovskite precursor solution, the compact and uniform FAPbI3 perovskite thin film with photovoltaic activity is obtained under the condition that methylamine ions are not introduced, the thin film has excellent thermal stability, the service life of a perovskite solar cell can be prolonged, and the service life of the perovskite solar cell is prolonged. And the positive significance is realized on the commercialized application of the perovskite battery.

The application relates to the field of catalytic synthesis, and discloses a methylamine synthesis method, which comprises the following steps: reacting methanol and ammonia in the presence of a zeolite catalyst treated by an organic alkali to generate a methylamine-containing stream; the acid amount of the zeolite catalyst treated by the organic alkali is 200-400 mu mol.g ‑1 The methylamine synthesis method can reduce the selectivity of trimethylamine in the reaction product, reduce the content of trimethylamine in the product, and ensure high methanol conversion rate.

The present application relates to the technical field of high polymer material modification, and particularly relates to a kind of heat-reversible crosslinking polyethylene material based on Diels-Alder synthesis and a preparation method thereof.The preparation method comprises: maleic anhydride polyethylene is melt grafted with excess furan methylamine, then is treated by high temperature and high pressure dehydration ring closure to form stable furan functionalized polyethylene; then melt blend with bismaleimide, and by low temperature long time annealing treatment, to promote Diels-Alder reaction to proceed fully, so as to build a perfect heat-reversible crosslinking network.The present application has the beneficial effects that the obtained heat-reversible crosslinking polyethylene material has excellent temperature mechanical strength, solvent resistance and clear heat-reversible characteristics, and can be uncrosslinked at higher than 150 DEG C to realize melt reprocessing, and the network is reconstructed after cooling, and the strength retention rate is still higher after two times of recycling.The present application solves the problem of non-recyclable traditional crosslinking polyethylene, and is particularly suitable for recyclable products such as packaging and pipe.

The application discloses a coating liquid for preparing a PCBM electron transport layer and application thereof. The coating liquid comprises a PCBM precursor, a lithium salt, an organic polymer and a methylamine halide salt. The coating liquid provided by the application improves the conductivity of the PCBM electron transport layer, increases the electron mobility, reduces the series resistance, increases the carrier recombination resistance, reduces the carrier recombination, improves the electron transmission and extraction efficiency, and further improves the open-circuit voltage, the short-circuit current and the fill factor of the prepared perovskite solar cell, finally improves the efficiency of the perovskite solar cell and the assembly; and the application method provided by the application is simple in process, low in cost and beneficial to commercial application.

This invention relates to the field of perovskite solar cell technology, and discloses a method for preparing a low-dimensional perovskite thin film and its solar cell. The method for preparing the low-dimensional perovskite thin film is as follows: Step 1, weighing p-fluorophenylethylamine iodine, methyl iodide, lead iodide, formamidine iodide, methyl ammonium chloride, and lead chloride, and dispersing them in a mixed solution composed of dimethylformamide and dimethyl sulfoxide to obtain a low-dimensional perovskite precursor solution; Step 2, dropping the low-dimensional perovskite precursor solution onto a substrate, rapidly spin-coating for 10-20 seconds, and then subjecting it to reverse-order cooling annealing to obtain a low-dimensional perovskite thin film. This invention rapidly forms a low-dimensional perovskite wet film through high-speed spin-coating, followed by reverse-order cooling annealing, which not only enables the preparation of low-dimensional perovskite thin films with vertically grown multiphase structures, but also has good repeatability and reduces the manufacturing cost of battery devices. The reverse-order cooling annealing process described in this invention is simple and suitable for industrial production.

The preparation of high-value-added aromatic carboxylic acids via CO2 carboxylation coupling through activation of the benzyl C-H bond in alcohols / amines is a green and sustainable pathway to achieve CO2 resource utilization and contribute to carbon neutrality. However, this field currently faces challenges such as poor catalyst selectivity, low CO2 activation efficiency, and a narrow substrate applicability range, making it difficult to meet practical application needs. To address this issue, this patent discovers that in a heterogeneous electrocatalytic system, cuprous selenide (V2), rich in selenium vacancies, can be used... Se -Cu 2‑x Using Se as the core catalyst, it can not only efficiently promote the synergistic activation of benzyl C-H bonds and CO2 carboxylation, significantly improving the overall catalytic activity of the reaction, but also achieve precise chemoselective carboxylation control for different types of substrates. Specifically, this V Se -Cu 2‑x Se electrocatalysts can efficiently and selectively activate the benzyl C-H bond in alcohols and subsequently induce CO2 carboxylation, exhibiting excellent chemoselectivity in the conversion of benzyl alcohol to mandelic acid and its derivatives. Simultaneously, they also demonstrate excellent catalytic performance for amines, selectively catalyzing the carboxylation of amine substrates such as benzylamine with CO2 to directionally generate phenylglycine and aromatic amine-derived carboxylates. Crucially, in addition to typical benzyl alcohol and benzylamine, the substrate applicability of this catalytic system can be extended to various alcohols and amine derivatives, realizing the carboxylation transformation from simple model substrates to diverse functional molecules, providing a new approach for the large-scale preparation of high-value-added aromatic carboxylates.

The application discloses a preparation method of a trans-7H-pyrrolo[2,3-d]pyrimidine compound, and the full name of the trans-7H-pyrrolo[2,3-d]pyrimidine compound is trans-N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexylmethanesulfonamide maleate, which is prepared from trans-4-[(tert-butoxycarbonyl)amino]cyclohexane carboxylic acid and 4-chloro-7H-pyrrolo[2,3-d]pyrimidine as starting materials through reduction, chlorination, substitution, oxidation, methylation, condensation and salt formation reactions. The preparation method has the advantages of few reaction steps, simple operation, low production cost, high production efficiency, high yield, high product purity and suitability for scale-up production.

This invention belongs to the field of chemical pharmaceutical technology, and particularly relates to a method for preparing an anti-puncture flash evaporation material. Addressing the issue that the hydrophilicity of the molecular structure in existing technologies needs improvement, this invention provides a maleic methylamine polyethylene glycol activated ester and its preparation method, comprising a reaction condensation of 3-maleimide propionic acid and tert-butyl methylamine polyethylene glycol propionate, followed by acid hydrolysis of the ester, and then adding the activated ester for a catalytic reaction to obtain the final product Mal-CH2CH2COO-N(CH3)-(PEG). n -CH2CH2COONHS. This invention creatively designs a maleic methylamine polyethylene glycol activated lipid structure. The methylamine structure can increase solubility in aqueous media, making it more hydrophilic than the existing Mal-CH2CH2COO-PEG-COONHS molecular structure, which is more conducive to the binding of drugs to the human body environment.

The invention discloses an ultra wide band gap perovskite thin film and application thereof, and belongs to the technical field of solar cells. The ultra-wide-band-gap perovskite thin film is prepared by the following steps: coating a perovskite precursor solution, carrying out post-treatment on a perovskite wet film by using an inducer, and then annealing to obtain a perovskite thin film, the inducer is selected from oleylamine chloride, methylamine chloride, formamidine chloride, guanidine chloride, octyl ammonium chloride, dodecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium chloride, octadecyl trimethyl ammonium chloride, dimethyl dioctadecyl ammonium chloride and tetradecyl trimethyl ammonium chloride. According to the invention, the chlorine source is introduced as an inducer, and post-treatment is carried out in the wet state of the thin film, so that homogenization of the surface of the thin film is realized, and the process can effectively solve the wrinkle problem of high fluctuation of the surface of the ultra-wide band gap perovskite, and provides a new solution for preparation of an efficient and stable full-perovskite triple-junction solar cell.

The present application relates to a kind of methods for producing taurine, methyl taurinate and methyl taurine using ethylene oxide, comprising: preparing taurine by ethylene oxide method, and obtaining taurine mother liquor;Mixing taurine mother liquor and methylamine, adding basic catalyst to carry out amination reaction, and obtaining reaction liquid;Evaporating ammonia and methylamine from the reaction liquid to obtain methyl taurinate solution;Preparing methyl taurine solution using the methyl taurinate solution;Concentrating and crystallizing the methyl taurine solution to obtain methyl taurine.The present application avoids the problem of recycling and using mother liquor in the production of taurine, reduces the possibility of impurity generation, and simultaneously realizes quantitative conversion to methyl taurinate and methyl taurine by controlling the molar ratio of raw materials and catalyst in the reaction.

This invention discloses a method for synthesizing a tenapano hydrochloride intermediate. The synthesis method includes the following steps: (1) condensing the compound 3-bromophenylacetaldehyde and the compound N-methyl-(2,4-dichlorophenyl)methylamine under dehydration conditions to obtain an enamine intermediate; (2) subjecting the enamine intermediate to an intramolecular cyclization reaction in the presence of an acid catalyst to obtain the tenapano hydrochloride intermediate 4-(3-bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline. The synthetic route provided by this invention requires only two steps to construct the key framework, and has the advantages of short reaction steps, high overall yield, and no need to use highly toxic liquid bromine. This process has high atom economy, reduces the emission of waste gas, wastewater, and solid waste, and is suitable for large-scale industrial production under mild conditions.

This invention relates to a method for preparing a graphene-based coated iron catalyst for the deep removal of trace amounts of acetylene and ethylene impurities from electronic-grade hydrogen chloride, belonging to the field of catalyst technology. The method involves dispersing phenolic resin and graphene quantum dots in toluene, adding allyltrimethylammonium bromide, ferrocene methylamine, and sodium ethoxide, heating and stirring the reaction, and adjusting the pH with acetic acid. Citric acid and ferric acetylacetone are then added, and the mixture is stirred. Sodium borohydride is added in two stages, and the reaction is continued with stirring to obtain a gel precursor. The gel precursor is then ultrasonically dispersed, dried, and subjected to staged heating in a nitrogen-hydrogen atmosphere to obtain the resin-based coated iron catalyst. The catalyst prepared by this invention can effectively remove trace amounts of acetylene and ethylene impurities from electronic-grade hydrogen chloride, improving the purity of electronic-grade hydrogen chloride.