1021 results about "Methylamines" patented technology

The invention relates to a chemical method for in-situ large-area controlled synthesis of a perovskite type CH3NH3PBI3 membrane material based on a lead simple-substance membrane. The method comprises: sputtering the lead simple-substance membrane on the surface of a substrate, then horizontally immersing the substrate material possessing the lead simple-substance membrane in an organic solution containing a simple substance iodine and iodinated methylamine, and performing a constant-temperature reaction to prepare a CH3NH3PBI3 membrane material in situ; or putting the substrate possessing the lead simple-substance membrane in a steam atmosphere of a simple substance iodine to perform iodination to generate a lead iodide membrane, then immersing in an organic solution containing iodinated methylamine, and performing a constant-temperature reaction to prepare the CH3NH3PBI3 membrane material in situ. The method is simple in operation, low in energy consumption and low in cost, and has wide industrial application prospect. The obtained CH3NH3PBI3 membrane is high in purity, uniform in membrane-surface crystal and excellent in crystallinity.

The invention relates to the field of medicine, in particular to an oleanolic acid derivative shown as a formula I, and pharmaceutically acceptable salts, a preparation method and purpose thereof. The invention also discloses application of the compound shown by the formula I to the preparation of anti-tumor medicine of 2-cyano-3, 12-dioxo oleanane-1, 9(11)-diene-28-carboxylic acid (XI, CDDO), 2-cyano-3, 12-dioxo oleanane-1, 9(11)-diene-28-carboxylic imidazole (XIII, CDDO-Im) and 2-cyano-3, 12-dioxo oleanane-1, 9(11)-diene-28-carboxyl methylamine (XIV, CDDO-MA).

The invention provides a 3-methylamine tetrahydrofuran preparation method, wherein 1,4-butenediol is adopted as a raw material and is subjected to cyclization dehydration under the catalysis effect of a solid acid to produce 2,5-dihydrofuran, the 2,5-dihydrofuran reacts with water gas under the catalysis effect of cobalt acetate to produce 3-tetrahydrofuran formaldehyde, and the 3-tetrahydrofuran formaldehyde, ammonia gas and hydrogen gas are subjected to a hydrogenation reaction under the catalysis effect of 5% Pd/C to prepare the target product3-methylamine tetrahydrofuran, wherein the purity is 98.12%, and the total yield is 74.16%. According to the present invention, the preparation method has advantages of cheap and easily available raw materials, less steps, simple operation, high product purity, high yield, less three-waste pollution and production cost reducing, and is suitable for industrial production.

The invention discloses a thermally-reversible self-repairing electrostatic dissipation polyurethane membrane and a production method thereof. The method comprises the following steps: uniformly mixing 4,4-diphenylmethane diisocyanate, polycaprolactone glycol and N,N-dimethyl formamide, reacting, cooling to a temperature being smaller than 5DEG C, adding 2-furanmethanamine, reacting, heating to 95-105DEG C, adding maleimido group-containing hyperbranched polysiloxane and functionalized carbon nanotubes, uniformly mixing, reacting the above obtained solution at 50-55DEG C to obtain a pre-finished product, pouring the pre-finished product into a die, and drying to obtain the thermally-reversible self-repairing electrostatic dissipation polyurethane membrane. A Diels-Alder (DA) reaction is used to realize thermal reversing and self repairing of the electrostatic dissipation polyurethane membrane; the electrostatic dissipation polyurethane membrane has the advantages of excellent thermal stability and electrostatic dissipation ability, and wide sources of raw materials; and the production method has the characteristics of simple process, strong practicality and extensive applicability.

Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waster or inedible, such as the leaves, peel and immature, unripe fruit. The materials contain as least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methylamine. Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.

Polysubstituted catechol-based universal solid supports suitable for synthesizing oligonucleotides have been prepared. Following synthesis, cleavage of the oligonucleotide from the solid support and catechol-assisted elimination of the 3′-phosphate group is accomplished by treatment with standard basic media such as ammonium hydroxyde or¹ methylamine.

The invention discloses an aryl-substituted chalcones compound, a preparation method and an application. The aryl-substituted chalcones compound has a structure shown as a formula(I) or a formula(II), wherein, R1, R2, R3, R4, R5 are aromatic groups or aromatic groups with a substituent, the aromatic groups are phenyl, furan, thienyl, pyridyl, pyrimidyl, thiazolyl or pyrrolyl, the substituent is one or more selected from hydroxyl, methoxyl, ethoxyl, methyl, ethyl, trifluoromethyl, halogen, amino, methylamino or dimethylamino; R3 is selected from hydrogen, amino or-NHCOCH3. The aryl-substituted chalcones compound introduces the aromatic groups based on a phenyl skeleton to form a structure with steric hindrance, the molecule presents a V-shaped spatial conformation, compared with the current chalcone compounds, and the aryl-substituted chalcones compound has higher inhibitory activity to cancer cells and can be used for preparing the antitumor drugs.

The invention relates to a novel nano-composite double network hydrogel and a preparation method thereof. The preparation method of the hydrogel comprises the steps of: performing a condensation (polycondensation) reaction of amines and epichlorohydrin or polyalcohol and aldehydes in clay solution to obtain a condensate (polycondensate)/clay composite first; and adding a hydrophilic monomer under the action of an initiator and a cross-linking agent to obtain the nano-composite double network hydrogel through free radical crosslinking polymerization, wherein in the condensation (polycondensation) reaction, the amines are selected from dimethylamine, methylamine, ethylamine, propylamine, diethylamine, quadrol, propylene diamine, diethylenetriamine, triethylenetetamine and tetraethylenepentamine, the polyalcohol is selected from glycol, propanediol, glycerol, butanediol, neopentyl glycol, pentaerythritol, polyvinyl alcohol, polyethylene glycol, glucose, sucrose, sorbierite, soluble starch and chitosan, the aldehydes are selected from formaldehyde, malonaldehyde and glutaraldehyde, clay is selected from laponite, bentonite or hydrophilic modified bentonite, and the hydrophilic monomer is selected from acrylic acid, acrylamide, N-Isopropylacrylamide, methacrylic acid, acrylonitrile and propene sulfonic acid. The novel hydrogel has the excellent mechanical strength under the condition of high moisture content.

The invention relates to a perovskite material based light-emitting diode and a preparation method therefor. The perovskite material based light-emitting diode comprises a transparent substrate layer, a transparent conductive electrode, an electron barrier layer or a hole barrier layer, a perovskite light-absorbing layer, a hole barrier layer or an electron barrier layer, and a metal conductive layer from the surface layer to the inner layer in sequence, wherein the perovskite light-absorbing layer comprises a lead halide complex; and the lead halide complex is prepared by the steps of mixing anhydrous lead halide powder with dimethyl sulfoxide solvent, or N, N-dimethylformamide solvent, or a tetrahydrofuran solution of methylamine, enabling PbX2 powder to be fully dissolved into the dimethyl sulfoxide solvent, or the N, N-dimethylformamide solvent, or the tetrahydrofuran solution of methylamine; and then adding chlorobenzene solvent, stirring, mixing, standing and filtering to obtain precipitates. According to the perovskite material based light-emitting diode and the preparation method therefor, the crystal transformation conditions of CH3NH3PbX3-nYn are lowered, the PbX2 impurity residual is reduced, the flatness of the thin film is improved, and the light-emitting efficiency of the perovskite layer thin film is improved.

The invention discloses a pyrrole ring containing hemifumarate which serves as a proton pump inhibitor as well as an intermediate and pharmaceutical application thereof, and particularly discloses a pyrrole ring containing 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)phenoxy)-N-methylacetamide hemifumarate which serves as a proton pump inhibitor and has a formula (I) as shown in the specification, a method for synthesizing the same from 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)phenoxy)-N-methylacetamide and fumaric acid and an preparation intermediate of the 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)phenoxy)-N-methylacetamide hemifumarate. The pyrrole ring containing 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)phenoxy)-N-methylacetamide hemifumarate disclosed by the invention has good stability, excellent biological activity and a good gastric acid inhibition effect.

The invention discloses a pesticide composition which takes indoxacarb and methylamino abamectin benzoate (be called emamectin benzoate for short) as the active component for killing pests. The invention is characterized in that the weight ratio of indoxacarb and memamectin benzoate is (1 to 100): 1, either emulsifiable oil, emulsion in water, microemulsion, suspension agent, wettable powder, or water dispersing granule is made by preparing moderately addition agent and the excipient. The pesticide composition has the advantages of effectively preventing and curing the major pests for the agriculture, being particularly applicable to prevent and cure the pest for the vegetables and cotton, significantly demonstrating less consumption, wide insecticidal spectrum, good drug efficacy, safe use, no hurt to human, livestock, and natural enemies.

The invention belongs to the pharmaceutical and chemical fields and particularly relates to a synthetic method of high-purity bortezomib and an intermediate of the high-purity bortezomib. According to the invention, N-(2- pyrazine carbonyl)-L-phenylalanine benzyl ester is obtained from condensation reaction between 2-pyrazine carboxylic acid and L-phenylalanine benzyl ester; then the product is catalyzed and hydrogenated; and then the product is condensed and hydrolyzed with the hydrochloride of (aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-alpha-(2-methyl propyl)-4,6-methano-1,3,2- benzodioxoborane-2-methylamine or trifluoroacetate so that the bortezomib is obtained. The preparation process disclosed by the invention has the advantages of simplicity in operation, high purity and low cost. The bortezomib obtained through the method disclosed by the invention is in the form of white powder or crystals, the content is 99.8% or higher, and the total content of SS- and RR-isomers is not greater than 0.1%.

The invention belongs to the technical field of chemical synthetic medicines and particularly relates to water soluble salts of an organic acid of 5-(2-fluorophenyl)-N-methyl-1-(3-pyridyl sulfonyl)-1H-pyrrole-3-methylamine and an injection thereof for treating gastric acid related diseases and a preparation method thereof. The invention discloses the salts of the organic acid of 5-(2-fluorophenyl)-N-methyl-1-(3-pyridyl sulfonyl)-1H-pyrrole-3-methylamine shown as the following general formula in the specification, wherein n is 1 or 1/2 and HA is an organic acid. According to the salts of the organic acid, which are disclosed by the invention, the solubility of the salts in water or an artificial gastric and intestinal juice is far greater than TAK438, and the solubility of pyroglutamate and lactate in water is greater than 1g/mL.

The invention discloses a quaternary phosphonium salt pillared layered zirconium phosphate material, and a preparation method and an application thereof. The chemical formula of the quaternary phosphonium salt pillared layered zirconium phosphate material is as follows, R is methyl, butyl, phenyl or alkane with the length of a carbon chain of 8-20; X is Cl or Br; and m is 1, and n is 0.00288-0.174462. The preparation method comprises the steps of utilizing methylamine to prop up an interlayer spacing interval of zirconium phosphate, obtaining a methylamine-zirconium phosphate precursor, then adding a quaternary phosphonium salt into the methylamine-zirconium phosphate precursor for continuously carrying out reaction for a certain time, replacing the methylamine in the precursor and obtaining the quaternary phosphonium salt pillared layered zirconium phosphate material with white or light gray external appearance, and the quaternary phosphonium salt pillared layered zirconium phosphate material can be added into plastics, rubber, fibers, coatings, adhesives, paper and other materials for preparing an antibacterial or flame-retardant functional material, and be also used for removing algae in water and governing large-area red tide and water blooms in fresh water.

The invention provides a mixed cation perovskite and a preparation method therefor. The mixed cation perovskite is characterized in that the mixed cation perovskite is formed by the mixing of methylamine cation, organic amine cation, metal cation and halogen anion according to a certain ratio. According to the invention, the performance of the prepared perovskite material is detected, and is represented through an X-ray diffraction. The perovskite material is compared with CH3NH3PbI3, thereby obtaining a similar spectrogram. The apparent characteristic peaks can be observed nearby 14.1 degrees, 28.5 degrees, 31.9 degrees, 40.5 degrees and 43.1 degrees, thereby indicating that the new perovskite material is obtained. A UV visible near-infrared spectrophotometer indicates that the absorption spectrum of the material covers the whole visible light range within 800nm. A fluorescence spectrophotometer indicates that the material has good photoluminescence quality, has an apparent fluorescence peak nearby 800nm, and accords with the fluorescence peak of the CH3NH3PbI3. Therefore, the prepared perovskite material is similar to the conventional CH3NH3PbI3, and has the good optical performance.

The present invention relates to a synthesis method of high-purity amlodipine besylate. In particular, o-chlorobenzaldehyde, 4-(2-phthalyl imino radical ethoxy) acetoacetic ester and 3-amino methyl cro-tonate are used as raw materials for ring closure in an alcohol solvent, and when the amount of the 3-amino methyl cro-tonate is three times, the intermediate for ring closure can be prepared; the intermediate is refined by toluene/glacial acetic acid, dissolved in methylamine to form a salt in the aqueous solution, and the high-purity amlodipine besylate can be acquired after recrystallization with ethyl alcohol.

The present invention provides Mannich base derivatives of N,N′-dimethyl secondary diamine polymers including Mannich base derivatives of methylamine-terminated poly-(N-methylazetidine) and Mannich base derivatives of methylamine-terminated poly-(N-methylazacycloheptane). Amine curing agent compositions and amine-epoxy compositions containing Mannich base derivatives of N,N′-dimethyl secondary diamine polymers are also disclosed.

The invention relates to a derivative of an aza-aryl compound as shown in the formula I, and the derivative is capable of adjusting erythropoietin (EPO). The derivative comprises the sodium salt, meglumine salt, hydrobromic acid and hydrochloride of the aza-aryl compound as shown in the formula I, and is high in solubility and water stability in an aqueous medium. In addition, the inventor discovers that the derivative is effective for treating cancers and related anemia.

The invention belongs to the field of medicines, and relate to a method for reducing palladium residue in a compound and a preparation method of high-purity fosaprepitant dimeglumine by applying the method. In the method, tributyl phosphane and triphenyl phosphine are used as palladium removing agent to treat compound solution. After palladium is removed by using the method, the high-purity fosaprepitant dimeglumine can be obtained through crystallization with poor solvent in one step. The residue of tributyl phosphane and triphenyl phosphine in a finished product is low, and the palladium residue limit is less than 1 ppm, therefore, the requirement of limit of palladium residue in crude drug for injection is satisfied, and the industrial production after magnification is further adapted.

The invention provides a novel preparation method of Apalutamide. According to the novel preparation method, 2-fluoro-4-bromo-N-methyl benzene methanamine amide, 1-amino cyclobutyl carboxylate hydrochloride, and the like are taken as initial raw materials, and substitution reaction is carried out so as to obtain 1-((3-fluoro-4-(methyl carbamyl)phenyl)amino) cyclobutane-1-carboxylic acid, wherein synthesis yield is higher than 70%, and purity is higher than 97.2%; then esterification is carried out so as to obtain 1-((3-fluoro-4-(methyl carbamyl)phenyl)amino) cyclobutane-1-carboxylic ester, wherein synthesis yield is higher than 83%, and purity is higher than 97.8%; and at last, ring closing reaction with 2-cyan-3-trifluoromethyl-5-isothiocyano pyridine is carried out so as to obtain Apalutamide, wherein yield is higher than 68%, and purity is higher than 98.1%. The preparation method possesses following advantages: the raw materials are easily available; technology is simple; operationis convenient; yield is high; and cost is low.