48 results about "Hypobromite" patented technology

A process for preparing a pyridone derivative (4), which comprises reacting the compound (1) with a hypochlorite or a hypobromite or with lead tetraacetate to give the compound (2), and reacting the compound (2) with the compound (3). Said process is preferably especially from the standpoint of safety. wherein R1 is hydrogen, alkyl, substituted alkyl, etc.; Y1 is hydrogen, alky, substituted alky, etc.; Y2 and Y3 are indenpently hydrogen, halogen, etc.; and L is alkyl, substituted alkyl, etc.

The invention discloses a preparation method of an amino pyridine bromide compound, relating to the field of organic synthesis. The amino pyridine bromide compound takes pyridine bromide formamide as raw material, and is prepared according to the following formula of Hofmann degradation reaction which comprising the following steps of: (1) dropping liquid bromine into alkali liquid with the concentration of 2.0-4.0 mol / L at -5-0 DEG C, reacting for 1.0 hour to obtain sodium hypobromite or potassium hypobromite, wherein the alkali is sodium hydroxide, potassium hydroxide or sodium methoxide; (2) adding the pyridine bromide formamide with the general foumula I to the hypobromite solution at room temperature for dissolving, raising temperature to 50-80 DEG C, reacting for 0.5-2 hours, decreasing temperature to 0 DEG C for separating out solids, and filtrating to obtain crude products; extracting the filtrate with an organic solvent, removing the solvent, and merging the crude products; re-crystallizing by using petroleum ether, and drying to obtain amino pyridine bromide. Wherein, the mole ratio of the general formula I to the alkali is 1:4-8, the mole ratio of the general formula I to water is 1:80-160, and the mole ratio of the general formula I to the liquid bromine is 1:1-2; and the organic solvent is dichloromethane, chloroform or normal hexane. The invention has the advantages of one-step reaction, simple process, low requirement on equipment, and high product purity, and the yield coefficient is around 50 percent.

The present invention relates to a portable bio-chemical decontaminant system and methods of using the same. Specifically, the present invention provides a portable bio-chemical decontaminant system that is rapidly effective across a broad range of chemical and biological weapons agents. The disclosed portable bio-chemical decontaminant system electrochemically generates a decontaminant solution at the point of use obviating the need to transport corrosive or reactive chemicals, and dramatically simplifies the logistics of delivering an effective bio-chemical decontaminant system to wherever it may be needed. The portable bio-chemical decontaminant system electrochemically generates chlorine dioxide and hypobromite.

The invention is a process for the preparation of stabilized aqueous solutions of alkali hypobromites, which comprises reacting a concentrated alkali hydroxide aqueous solution with bromine, allowing the mixture to react, adding to the reaction product, which is a non-stabilized solution, an aqueous solution of a sulfamic compound, such as sodium sulfamate, and thus forming stabilized alkali hypobromite solution. This solution can be further stabilized by the addition of a sulfamate solution. The temperatures of all the above stages are comprised between −5 and +10° C.

Nucleoside compounds represented by formula (II) may be prepared by subjecting a 2′,3′,5′-triacyloxynucleoside compound represented by formula (I) to deacylation using alkali metal hydroxide in a 0.01- to 0.5-fold amount in a molar ratio relative to the moles of the 2′,3′,5′-triacyloxynucleoside compound. The production method of the nucleoside compound of formula (II) suppresses the formation of by-products, and the products amy be used for the production of nucleoside derivatives. In addition, oxidation of a nucleoside compound represented by formula (1) in the presence of a 2,2,6,6-tetramethylpiperidine-1-oxy catalyst, and hypochlorite or hypobromite, while adjusting pH to fall within 5 to 9, and further, extracting a nucleoside-carboxylic acid compound represented by the formula (2) into an organic solvent under acidic conditions, back-extracting the compound from the organic solvent into an aqueous alkali solution, and neutralizing the aqueous alkali solution by adding an acid thereto affords highly pure crystals of the compound of formula (2) or a salt thereof. wherein each symbol is as defined in the Description.

The method for surface inclusions detection, enhancement of endothelial and osteoblast cells adhesion and proliferation and sterilization of electropolished and magnetoelectropolished Nitinol implantable medical device surfaces uses an aqueous solution of chemical compounds containing halogenous oxyanions as hypochlorite (ClO−) and hypobromite (BrO−) preferentially 6% sodium hypochlorite (NaClO).

The invention relates to an improved synthesis method for hydantoin bromo and for preparing dibromohydantoin or bromo-3-chloro-5,5-dimethylhydantoin. The method comprises the following steps of: taking various hydantoins as raw materials, dissolving the hydantoins and the corresponding amount of bromide in 0.2g / mL saturation chlorate solution, electrolyzing the bromide solution and obtaining the corresponding hypobromite, generating hypobromous acid under the condition of addition of acid, further performing bromo reaction to the hydantoin, adjusting the bromide equivalent according to demand and synthesizing the corresponding dibromohydantoin or bromo-3-chloro-5,5-dimethylhydantoin. Reaction liquid can be repeated and used, and the reaction yield can reach more than 95%. The invention has the advantages of easy obtainment of raw materials by low cost, low production cost, simple post treatment, high yield, good purity and repetitive recycle of the mother liquid. By utilizing the electrolysis process, the process is simple, and the equipment has low requirement, safe operation and no toxicity or stimulation.

A membrane entrance mass spectrometer based method for analyzing content of dissolved nitrogen isotope comprises the following steps: 1, introducing helium into the liquid to be tested for 20 min to remove nitrogen dissolved in water; 2, adding an oxidant iodine hypobromite solution in the liquid to be tested with nitrogen removed to oxidize ammonia nitrogen into nitrogen; 3, determining a standard curve through a standard sample membrane entrance mass spectrometer; 4, measuring the liquid to be tested from the step 2 by the membrane entrance mass spectrometer, and calculating the content of nitrogen isotope in the ammonia nitrogen liquid; 5, removing the original ammonia nitrogen in the liquid to be tested treated in the step 2 by magnesium oxide, acidifying with sulfuric acid, then reducing nitrate to ammonia nitrogen by zinc powder, and then use the above step 2 to step 4 to obtain the content of nitrate nitrogen isotope in the solution. The method provided by the invention can fast and accurately measure and analyze the content of dissolved nitrogen isotope, and is conducive to promoting the application of nitrogen isotope tracer technique.

The invention provides a method for reducing bromine levels in brine solutions such as potassium chloride brine solutions. Bromide in solution is converted to hypobromite by the addition of an oxidant such as sodium hypochlorite. Hypobromite is precipitated by the addition of a metal cation such as magnesium under conditions of basic pH. The process is pH dependent such that the most efficient removal of bromine is achieved at a sodium hydroxide concentration of 90-200 mM. The pH optimum is also temperature dependent such that increased temperature lowers the optimal pH for bromide removal. The invention further provides a bromine-reduced potassium chloride product, suitable for uses in industrial applications. By the method of the invention bromine levels in a potassium chloride feed stock can be reduced by 97% or more.

Provided is a method for treating water containing cyanogen and ammonia with which cyanogen and ammonia are sufficiently decomposed even in cases where the concentration of soluble iron is high. This method for treating wastewater containing cyanogen and ammonia involves a step for oxidizing and decomposing cyanogen and ammonia by adding a chemical solution including hypobromous acid and / or hypochlorous acid to wastewater containing cyanogen and ammonia. A solution in which hypobromous acid and / or a hypobromite have / has been produced by mixing a bromide aqueous solution and a hypochlorite aqueous solution is added to wastewater containing cyanogen and ammonia. A sodium bromide aqueous solution and a sodium hypochlorite aqueous solution are mixed and added at an equimolar ratio or such that sodium hypochlorite is excessive.

A process is described for treating water, in particular for producing ultrapure water, in which a water stream is passed through a plurality of treatment stages in which inorganic and / or organic species which are present in the water are separated off, wherein an aqueous hypobromite solution is added to the water stream in at least one of the stages. Furthermore, a water treatment system for carrying out such a process is described, comprising one or more means for separating off inorganic and / or organic species from a water stream, characterized by at least one device for generating hypobromite solution, which device is connected to the water stream via at least one hypobromite feed line.

The invention relates to a preparation method for N-aminopiperidine hydrochloride, particularly relating to a method for synthesizing N-aminopiperidine hydrochloride by piperidine, which is characterized in that the following steps are adopted: a piperidine reacts with a cyanate under an acidic condition to derive an N-carbamoyl piperidine; the N-carbamoyl piperidine reacts with a hypochlorite or hypobromite under a basic condition; after the N-carbamoyl piperidine is rearranged by Hoffman and treated by hydrochloric, the N-aminopiperidine hydrochloride is derived. In the preparation method of the invention, the reaction time of each step is short, the reaction condition is mild (normal temperature and normal pressure reaction at most of the time), the after-treatment is quite easy and a column chromatography is not needed; the method of the invention is a simple operated, economical, practical and safe synthetic method with a yield of more than 60 percent.

The invention discloses a reaction system for halogenating ion exchange resins. The reaction system comprises a catalyst and a halogenating agent, wherein the catalyst is chloride and / or bromide; the mass of the catalyst accounts for 0.1%-5% of the mass of ion exchange resin to be halogenated; the halogenating agent comprises a solution A and a solution B, the solution A is hydrochloric acid of which the concentration is 0.1mol / L-12mol / L and / or hydrobromic acid of which the concentration is 0.1mol / L-12mol / L, the solute of the solution B is one or more hypochlorite, chlorate, perchlorate, hypobromite, bromate and perbromate. Furthermore, the invention also discloses a halogenation method of ion exchange resins. According to the reaction system for halogenating ion exchange resins disclosed by the invention, low-toxic salts and acids are adopted as halogen sources instead of chlorine and bromine with high toxicity, and all materials in the operation are liquid or solid and thus the potential safety hazard of toxic gas leakage is avoided and the reaction system is safer.

The present invention provides a process for preparing a tribromomethylsulfonylpyridine, which comprises reacting a methylthiopyridine and a hypobromite in the presence of a base and water in a heterogeneous system. According to the present invention, it is possible to prepare a tribromomethylsulfonylpyridine industrially advantageously, and with high yield and high purity.

The invention provides a synthesis method of 2, 3-dichloropyridine, which comprises the following steps: reacting cyclopentanone with hydroxylamine hydrochloride, and taking sodium hydroxide as an acid-binding agent to obtain a compound A; carrying out Beckmann rearrangement reaction on the compound A under the action of thionyl chloride to obtain a compound B; reacting the compound B with sodiumborohydride under the catalysis of cobalt acetate to obtain a compound C; reacting the compound C under the catalysis of ammonium chloride to obtain a compound D; reacting the compound D with chlorineunder the action of azodiisobutyronitrile to obtain a compound E; and reacting the compound E with tert-butyl hypobromite to obtain 2, 3-dichloropyridine. The method is simple in operation steps, theused reaction raw materials are cheap and easy to obtain, the total molar yield is 68.88%, the purity of the produced 2, 3-dichloropyridine is 98.0% or above, the product quality is good, and the method is suitable for industrial production.

The invention relates to a rapid high-selectivity hypobromous acid fluorescence probe, and a preparation method and an application thereof. The fluorescence probe is a 1-(2-aminoethyl)piperidine compound, and can be used for measuring, detecting or screening hypobromite and carrying out living cell fluorescence imaging as a hypobromite fluorescence probe. The probe can realize at least one of high-selectivity identification of hypobromite, rapid response to hypobromite, ultra-sensitive analysis of hypobromite and detection of hypobromite under physiological level conditions, and also has the advantages of strong anti-interference capability, simplicity in synthesis, and stable properties.

The invention provides a preparation method of 4-alkyl-5-formoxyl thiazole or 5-formoxyl thiazole shown by a formula II, which comprises the following step of: in mixed phase formed by organic solvent and a water solution with the pH value of 7-9, enabling a compound shown by a formula I to have oxidation reaction with oxidizing agent under the conditions that catalyst exists and the reaction temperature is 0-40 DEG C to generate a compound shown by the formula II, wherein R1 is H or linear chain or branched chain alkyl group of C1-C3, the oxidizing agent is hypochlorite or hypobromite of alkaline-earth metal or alkaline metal, and the catalyst is 2, 2, 6, 6-tetramethyl piperidine 1-oxy-free radical (Tempo) and derivatives of the 2, 2, 6, 6-tetramethyl piperidine 1-oxy-free radical (Tempo). The method is mild in reaction conditions, low in price of raw materials, easy in obtaining of raw materials and smaller in reaction molar volume, does not need KBr for catalysis, and is simple in aftertreatment, thus being suitable for industrial production and environment-friendly; and the method can be used for producing 4-methyl-5-formoxyl thiazole which is high in yield and purity and is a key intermediate of cefditoren pivoxil.

Provided is a method for treating ammonia-containing water in which the generation of hazardous gas is prevented even at the time of decomposing high concentrations of ammonia, and that is also suitable for partially decomposing ammonia. This method for treating wastewater containing ammonia involves a step for oxidizing and decomposing ammonia by adding a chemical solution including hypobromous acid and / or hypochlorous acid to wastewater containing ammonia. A solution in which hypobromous acid and / or a hypobromite have / has been produced by mixing a bromide aqueous solution and a hypochlorite aqueous solution is added to wastewater containing ammonia. A sodium bromide aqueous solution and a sodium hypochlorite aqueous solution are mixed and added at an equimolar ratio or such that sodium hypochlorite is excessive.

Provided are: a semiconductor treatment liquid containing a hypobromite ion, in which the concentration of the hypobromite ion is 0.1 μmol / L or more and less than 0.001 mol / L; a RuO4 gas generation inhibitor containing an onium salt composed of an onium ion and a bromine-containing ion, in which the hypobromite ion concentration is 0.1 μmol / L or more and less than 0.001 mol / L; and a method of producing a halogen oxyacid, the method including allowing a bromine salt, an organic alkali, and a halogen to react with each other to obtain the halogen oxyacid.

The invention is a process for the preparation of stabilized aqueous solutions of alkali hypobromites at low temperatures, which comprises reacting a concentrated alkali hydroxide aqueous solution with bromine, and adding to the reaction product, which is a non-stabilized solution, an aqueous solution of a sulfamic compound, such as sodium sulfamate, thus forming a stabilized alkali hypobromite solution.