43 results about "Biological media" patented technology

The invention relates to a method for evaluating the radiation dose of special public nearby a nuclear facility, and the method comprises the steps: estimating the concentration distribution of radionuclides in air, surface soil and a biological medium nearby the nuclear facility through collecting the radiation dose evaluation parameters of a target special public and combining an environment quality evaluation model; based on the data, the annual effective dose of the target special public at the nuclear facility boundary and the living quarter is calculated, and a plurality of ways such as inhalation internal irradiation, air immersion external irradiation, surface deposition external irradiation and ingestion internal irradiation are considered. In addition, a dynamic calculation method is also introduced, especially for the influence of year-by-year change of the cumulant of radionuclides deposited on the earth surface, factors such as decay, resuspension and infiltration into underground water of nuclides are fully considered, and the accuracy and foresight of evaluation are improved. Accurate and comprehensive technical support is provided for radiation protection of the special public around the nuclear facility, and the requirements of the nuclear facility public for dose monitoring and risk management are met.

The invention relates to the field of garbage treatment equipment, in particular to biological medium type oil stain separation sewage treatment equipment which structurally comprises a machine body, a garbage processor is mounted in the machine body, a discharging groove is further formed in the side edge of the machine body and connected with the discharging end of the garbage processor, and a stirring bin is arranged at the top of the machine body; the stirring bin comprises a bin body, a plurality of sets of rotatable stirring shafts are arranged in the bin body, bottom grooves are formed in the bottom of the bin body, a rotatable conveying belt is installed between the bottom grooves, a driving roller of the conveying belt penetrates through the side edge of the bin body, and the conveying belt rotates in the axial direction of the driving roller. When the conveying belt downwards moves and rotates towards one side of the auxiliary side plate, a cavity is formed between the surface of the conveying belt and the auxiliary side plate so that the biological balls needing to be cleaned can be concentrated, the biological balls can be turned over under rotary conveying of the belt body, and a better cleaning effect can be achieved under washing of a jet flow device; and peculiar smell caused by biological ball blockage is avoided.

A apparatus including: a silicone-based body oriented down a central axis, the silicone-based body comprising: a rigid frame having a top axial surface and a bottom axial surface, an outer surface, and a substantially arcuate inner surface; and a plurality of gas-permeable, flexible film membranes connecting the inner surface about a perimeter of the rigid frame at the top axial surface and the bottom axial surface respectively to define an internal void within the body, wherein the rigid frame has a plurality of corrugations along the top axial surface and the bottom axial surface, and wherein the internal void provides for a medically, biologically, chemically, or pharmaceutically active environment.

An apparatus including: a core including an annular body defining an internal void oriented down a central axis having a top axial surface and a bottom axial surface; at least one retainer including an annular body adapted to couple to the top axial surface or the bottom axial surface of the core to form a circumferential engagement cavity defined radially between the at least one retainer and the core; at least one ring seal disposed within the engagement cavity; and at least one flexible film membrane partially disposed within the engagement cavity, where the at least one flexible film membrane at least partially encloses the internal void to provide for a medically, biologically, or pharmaceutically active environment within the internal void of the core.

The utility model relates to the technical field of sewage treatment equipment, and discloses buried sewage treatment equipment for a clean workshop, which comprises a ground, a filtering tank is fixedly connected to the inner wall of the right side of the ground, the right side of the outer wall of the filtering tank is communicated with a water inlet pipe, and a plurality of brackets are connected to the middle upper part of the inner wall of the filtering tank at equal intervals; the adjacent sides of the multiple supports are each rotationally connected with a paddle fan, a blocking plate is fixedly connected to the middle of the inner wall of the filtering tank, multiple reactors are arranged on the inner wall of the blocking plate in a penetrating mode, and an air inlet is formed in the right end of the top wall of the filtering tank. According to the sewage treatment device, sewage to be treated is introduced into the filtering tank, the paddle fan is used for stirring the sewage, the mixing and stirring effects of the sewage are enhanced, a biological medium and a catalyst in the reactor are used for further decomposing and converting harmful substances in the sewage to ensure that the device can efficiently and stably run, and the expected sewage treatment effect is achieved.

The invention relates to the field of biological metal materials, in particular to application of an amorphous alloy in the field of biological metal materials, which comprises the following steps: preparing Zr, Cu, Al, Ag and Fe raw materials, preparing the raw materials into an alloy ingot with the component of Zr50Cu (34-x) FexAl8Ag8 according to atomic percent, putting the alloy ingot into a vacuum non-consumable arc melting furnace for melting, and then suction casting is carried out to prepare the amorphous alloy bar. The amorphous alloy Zr50Cu (34-x) FexAl8Ag8 is applied to be used as a biological metal material. By the adoption of the technical scheme, compared with Zr-Cu-Al-Ag, better corrosion resistance in a biological medium is obtained, and the content of the harmful element Cu in the alloy is reduced.

A random terpolymer of N-(2-hydroxypropyl) methacrylamide, carboxybetaine methacrylamide and sulfobetaine methacrylamide, and a polymer brush and to a functionalized polymer brush containing this terpolymer are disclosed. The random terpolymer increases the resistance of the substrate surface to non-specific adsorption of substances from biological media and / or to non-specific interaction with biological media components, and is suitable for use in the form of a polymer brush, for example in sensors or membranes.

The present invention relates to microfluidic technology, and particularly to a medium delivery system. A medium delivery system includes a driving component and a first flow channel. There is a driving medium and a working medium in the first flow channel. There is driving medium at both ends of the first flow channel, and the working medium is located between the driving media; both ends of the second flow channel are located between the two ends of the first flow channel. An inlet and an outlet communicating with an external pipeline are provided in the second flow channel. The working medium flows in the external pipeline. The working medium in the first flow channel and at least one second flow channel can flow along a first preset direction, so that the working medium flows from the inlet to the outlet. The driving component can drive the working medium in the first flow channel to flow in a direction opposite to the first preset direction through the driving medium to return to the initial position. The advantage is that the driving component indirectly drives the working medium through the driving medium, avoiding the mechanical structure in the driving component from damaging the biological medium.

The invention discloses a schistosomiasis transmission risk dynamic simulation method based on data fusion and AI, and relates to the technical field of intelligent medical treatment. The method comprises the following steps: firstly, collecting environment, biological media, crowd society and intervention measure multi-source heterogeneous data, and unifying the data to a standard spatio-temporal data cube; then data preprocessing is carried out, and feature variables strongly related to propagation risks are constructed; then the processed data and the characteristic variables are input into a risk simulation engine, the engine adopts a hybrid framework in which a mechanism model and an AI prediction model are deeply fused, a dynamic assimilation algorithm is introduced, and risk level maps of different spatial and temporal scales in the future are output; finally, intervention measure scene simulation is carried out based on the risk level map, the cost-benefit ratio is quantitatively evaluated, and an optimal prevention and control strategy suggestion is generated. According to the method, the hysteresis and static defects of a traditional method are overcome, and real-time sensing, dynamic prediction and intelligent decision support of the schistosomiasis transmission risk are achieved.

The present disclosure provides methods of training a deep learning (DL)-based classifier to classify a digital histopathology image with respect to a phenotype, methods of classifying a digital histopathology image with respect to a phenotype, and methods of identifying a biological mediator associated with a pathology, pathophysiology, or other clinical characteristic. The disclosure further provides systems for implementation of these methods.

Bioreactor and a Bioreactor Vessel A rigid-walled bioreactor vessel is provided for containing a biological medium. The vessel includes one or more heat exchange channels for exchanging heat with contents of the vessel. The or each channel is integrated into the wall of the vessel such that the material of the wall also forms the one or more 5 channels. The or each channel has a respective inlet configured to receive a flow of a heat exchange fluid into the channel, and a respective outlet configured to discharge the flow of the heat exchange fluid from the channel

A bioreactor includes a rigid-walled vessel for containing a biological medium, the vessel having a lid. The bioreactor further includes a probe passing through an aperture in the lid and having a sensing end inside the vessel and a remote end outside the vessel. The sensing end has plural electrodes for immersion in the biological medium, and the remote end is configured for coupling to external devices and transmission thereto of electrical or electromagnetic measurements made by the electrodes. One of the lid and the probe has one or more resiliently deformable mechanisms and the other of the lid and the probe has one or more respective complementary surfaces. The resiliently deformable mechanisms and the complementary surfaces are configured such that, on insertion of the probe through the aperture to assemble the probe to the lid, the one or more resiliently deformable mechanisms are first deformed on sliding against the one or more complementary surfaces and then resile when the probe reaches a predetermined insertion position relative to the lid to secure the probe to the lid. One of the lid and the probe carries a sealing element which seals the probe to the lid when the probe is secured at the predetermined position.

A bioreactor system for carrying out a biological process including a vessel for receiving a liquid biological medium, and a gassing installation for controlled supply of different gases from gas sources into the vessel. The gassing installation has a plurality of gas outlet lines which open into gassing devices and / or into an overlay gas outlet in the interior of the vessel. Each gas outlet line is connected to a plurality of gas sources via a respective gas supply line or via a respective branch from a gas supply line. A mass flow controller connected to a controller is arranged in each gas supply line and in each branch. The system may include a controller with a master controller for a controlled variable, at least one sensor associated with the master controller, and one or more slave controllers having actuators, the manipulated variables of which purposefully influence the controlled variable.

An apparatus including: a core including an annular body defining an internal void oriented down a central axis having a top axial surface and a bottom axial surface; at least one retainer including an annular body adapted to couple to the top axial surface or the bottom axial surface of the core to form a circumferential engagement cavity defined radially between the at least one retainer and the core; at least one ring seal disposed within the engagement cavity; and at least one flexible film membrane partially disposed within the engagement cavity, where the at least one flexible film membrane at least partially encloses the internal void to provide for a medically, biologically, or pharmaceutically active environment within the internal void of the core.

The invention discloses a microwave terahertz wave modulation method for medical imaging, which comprises the following steps that: a transmitting end generates a terahertz carrier signal through a frequency multiplication technology, and removes irrelevant frequency components by using a band-pass filter; a baseband signal and a terahertz carrier signal are modulated, and a Gaussian noise and temperature noise module is combined to simulate a transmission environment; a receiving end recovers the baseband signal through band-pass filtering, demodulation, low-pass filtering and quantization judgment, and carries out signal reconstruction and comparison; the method is used for constructing a biological medium model according to dielectric constant characteristics of biological tissues in a terahertz frequency band, and simulating the propagation process of signals in the biological tissues, including attenuation, dispersion and scattering phenomena. The method provided by the invention has the following advantages: (1) high-precision modulation and demodulation of terahertz carrier signals under complex conditions can be realized; (2) the method is used for a biological medium model, effectively simulates the propagation law of signals in biological tissues, and adapts to the influence of dielectric properties of different tissues; (3) binary amplitude keying (2ASK) modulation is adopted, the system is simple in design and easy to realize, and the demodulation process is high in precision; (4) the system simulation is simple for the establishment of a hardware system, and is convenient for practical engineering application; and (5) the robustness of signal reconstruction is improved, a noise interference environment is adapted, and the accuracy and stability of signal transmission are ensured.

Described herein are electrochemical capacitive biosensors, methods of making same, and methods of using same. The electrochemical capacitive biosensors are especially useful for detecting pathogens, including viruses, bacteria, and allergens, in aerosols and complex biological media.

The invention relates to a module for determining the viscoelastic properties, referred to as the module, of a moving biological medium of variable thickness, referred to as the medium, at least partially enclosed in an elastic biological environment. The module comprises a processing unit arranged to calculate, from propagation data of at least one shear wave in the medium, a dispersion curve of the at least one shear wave in the medium, and to determine, from the dispersion curve of the at least one shear wave in the medium and a propagation mode of the at least one shear wave in the medium, a thickness of the medium and / or the viscoelastic properties of the medium. Figure for the abstract: FIGURE 3

The invention discloses a preparation method of a 3D cell culture body. The preparation method comprises the following steps: (A) constructing a framework based on a sacrificial material; (B) arranging a first culture cell and a curable biological medium around the skeleton, and then curing the biological medium to form a cured biological medium block; (C) covering the biological medium block with a curable packaging material, then curing the packaging material, and forming a packaging layer on the outer side of the biological medium block; and (D) removing the skeleton so as to form a perfusion structure in the biological medium block, thereby obtaining the 3D cell culture body.

Femtosecond pulse near-infrared Gaussian laser is adopted as a unified light source and is simultaneously used for time-sharing scanning optical tweezers capturing and two-photon fluorescence excitation, and a light path part is sequentially provided with a height adjusting assembly, a galvanometer scanning element, a beam expanding assembly and a telescope assembly. The light is reflected by a dichroscope configured on an inverted microscope platform, strong focusing is realized in a PDMS sample chamber by a high numerical aperture objective lens, bright field illumination is provided by a white light LED lamp, and a two-photon fluorescence signal is collected by a CMOS camera; a high-precision biosensing system based on a CRISPR / Cas12a system is constructed on the surface of a microsphere enriched with a detection signal output unit, quenching-recovery conversion of a fluorescence signal is realized, and two-photon fluorescence imaging is carried out in a multiple optical capture microsphere array formed by time-sharing scanning optical tweezers. The method has the advantages of high detection accuracy and sensitivity, low background signal, good imaging stability, strong anti-interference capability in a complex biological medium and the like.

The invention relates to a bioreactor system (10) for carrying out a biological process, comprising a container (12) for accommodating a liquid biological medium and a gas supply system for the controlled delivery of different gases from a gas source (38, 40, 42, 44) into the container (12). According to the invention, the gas supply system has a plurality of gas outlet lines (28, 30, 32) which open into the one or more gas supply devices (20) and / or into the cover gas outlets in the interior of the container (12). Each gas outlet line (28, 30, 32) is connected to a plurality of gas sources (38, 40, 42, 44) via a respective gas delivery line (46, 52, 56, 58) or a respective branch (48, 50, 54, 60) of the gas delivery line (46, 52, 56, 58). A mass flow closed-loop controller (62) connected to the control unit is provided in each gas delivery line (46, 52, 56, 58) and in each branch (48, 50, 54, 60). Such a bioreactor system for performing a biological process preferably comprises an open-loop control mechanism comprising a main closed-loop controller for closed-loop control of variables, at least one sensor associated with the main closed-loop controller, and one or more servo closed-loop controllers with regulating elements (14, 62), the control variable of the control element influences the closed-loop control variable in a targeted manner. The open-loop control mechanism is configured such that a desired value for a closed-loop control variable can be preset for the main closed-loop controller, and the at least one sensor is used to repeatedly determine an actual value of the closed-loop control variable, and the main closed-loop controller provides an output signal related to the deviation of the actual value of the closed-loop control variable from the expected value of the closed-loop control variable to the servo closed-loop controller. An open-loop control curve is assigned to the servo closed-loop controller, the open-loop control curve relating to an output signal of the main closed-loop controller. According to a first alternative, the open-loop control curve contains a desired value for a regulating element (14, 62) of the servo closed-loop controller, and the open-loop control mechanism is configured such that the desired value for the regulating element (14, 62) can be input in physical units of its regulating variable. According to a second alternative, the open-loop control curve contains a desired value for a parameter which is directly dependent on the biological process and which can be influenced in a targeted manner by the regulating element (14, 62), and the open-loop control mechanism is configured such that it automatically assigns a desired value for the regulating element of the servo closed-loop control for the parameter desired value.

Described herein are electrochemical capacitive biosensors, methods of making same, and methods of using same. The electrochemical capacitive biosensors are especially useful for detecting pathogens, including viruses, bacteria, and allergens, in aerosols and complex biological media.

A system, a kit, and a method of cleaning a bioreactor in which wastewater is treated, the bioreactor housing biomedia in suspension in the wastewater. The method includes withdrawing at least some of the wastewater from the bioreactor into a separator. The wastewater includes a mixture of sludge and water. The method further includes processing the withdrawn wastewater to separate at least some of the sludge from water. The method further includes returning at least some of the processed wastewater from the external housing to the bioreactor, the processed wastewater having a lower sludge content than the sludge content in the wastewater of the bioreactor before it was processed.

The application relates to the field of biosensors, and particularly relates to a biosensor based on a graphene double-material gate tunneling field effect transistor, which comprises a graphene channel, a source electrode, a drain electrode, an insulating medium layer, a silicon substrate, a gate medium layer, a first gate electrode, a second gate electrode, a biological medium layer and a biological nanocavity; the silicon substrate, the insulating medium layer, the graphene channel and the gate medium layer are sequentially stacked from bottom to top; the source electrode and the drain electrode are located on the left and right sides of the graphene channel; the biological medium layer and the second gate electrode are respectively stacked on the left and right end portions of the upper surface of the gate medium layer, and the biological medium layer is hollow to form the biological nanocavity; the first gate electrode is stacked on the upper surface of the biological medium layer; the work functions of the metal materials of the first gate electrode and the second gate electrode are different. The application can comprehensively control the energy band of the graphene channel, can realize energy band tunneling between the graphene without doping the graphene, has a relatively simple manufacturing process, and has high sensitivity.

This invention discloses a method for surface processing of medical metal instruments with anti-adhesion properties, comprising the following steps: S1, pretreating the substrate surface of the medical metal instrument; S2, using a femtosecond laser to scan and etch the pretreated substrate surface to construct a biomimetic microtexture with micron-level structural features and nanometer-level roughness; S3, immersing the surface treated in step S2 in a stearic acid-ethanol solution for chemical modification to form a hydrophobic molecular layer on the surface of the biomimetic microtexture, thereby obtaining a superhydrophobic anti-adhesion surface. This invention can stably construct biomimetic micro / nanostructures with excellent superhydrophobic properties on the surface of medical metal instruments, thereby significantly reducing the adhesion of biological media such as blood and tissue, improving surgical efficiency and instrument lifespan.

A system and / or method is disclosed to suppress adsorption and / or biofouling on a surface in a biological medium by means of an alternating electric field. For example, one or more insulating electrodes may be disposed near the surface. For example, insulation may limit the current between the biological medium and the electrodes, and / or between the surface and the electrodes, and / or between the plurality of electrodes. In some embodiments, the alternating charge near the surface may suppress the accumulation of multiple biofilms and / or adsorption onto the surface. For example, the system may be used to suppress fouling of an implantable medical device (e.g., a catheter).

A bioprocessing installation comprising a reservoir tank, one or more fluid lines, one or more receiving containers and an electronic control unit. The fluid line fluidically connects the reservoir tank to a receiving container. The liquid biological medium can be transferred from the reservoir tank through the fluid line into the at least one receiving container. The bioprocessing installation comprises a sensor arrangement with at least one gas bubble sensor, which sensor arrangement is configured to detect one or more gas bubbles or foam or separated phases in the liquid biological medium by a gas bubble sensor and to generate one or more corresponding sensor signals, and the electronic control unit is configured to monitor the transfer of the liquid biological medium from the reservoir tank in the direction of the at least one receiving container based on the sensor signals generated by the sensor arrangement.

The invention belongs to the technical field of nano motors, and particularly relates to an MXene (at) Au photo-thermal nano motor and a preparation method and application thereof. The MXene (at) Au composite nano motor provided by the invention comprises a modified single-layer MXene nanosheet and an active component loaded on the surface of the modified single-layer MXene nanosheet, the active component is a gold nano-cluster coated with bovine serum albumin; the modified single-layer MXene nanosheet is obtained by modifying with a cationic surface active agent; the loading is realized through an electrostatic adsorption effect. The MXene (at) Au nano motor provided by the invention generates an asymmetric thermal gradient under illumination to drive the nano motor to realize self-propelling movement in a solution, so that the diffusion efficiency and the A beta targeted enrichment capacity in a complex biological medium can be remarkably enhanced, and further efficient recognition and photo-thermal degradation of A beta protein aggregates are realized.

Bioreactor, a Bioreactor Vessel and a Closure Component for a Bioreactor Vessel A closure component is provided for closing an upper opening of a rigid-walled bioreactor vessel, in use the vessel containing a biological medium and the upper opening providing access to the interior of the vessel. The component has: a lid having a mounting for fixing to a rim of the upper opening such that the lid closes the upper opening; a shaft which extends downwards from the lid; and one or more impellers mounted to the shaft. The mounting forms a bearing with the rim of the opening when fixed thereto. The lid, the shaft and the one or more impellers are integrally formed such that the component is a one-piece assembly in which the lid, the shaft and the one or more impellers are rotatable together as a single unit to stir the contents of the vessel.

A system and / or method are disclosed to inhibit sorption to a surface in a biological medium and / or biofouling by means of an alternating electric field. For example, one or more insulated electrodes may be positioned near the surface. For example, insulation may limit electric current flow between the biological medium and the electrode and / or between the surface and the electrode and / or between the electrodes. In some embodiments, the alternating charge in the vicinity of the surface may inhibit the buildup of biological films and / or sorption to the surface. For example, the system may be used to inhibit fouling of an implanted medical device (e.g. a catheter).

A sensor positioning system for a bioprocess engineering unit, wherein a container is provided for receiving a biological medium which, when installed, extends in the axial direction from an upper container end to a lower container end, wherein a holder is provided for holding the container when installed, wherein a sensor is provided for fixing to the container. A positioning aid device for positioning the sensor to be fixed is provided on the container, the positioning aid device has a positioning aid that can be applied directly to or near the container on the holder, which can be brought into different vertical positions and / or circumferential positions relative to at least one reference point provided on the container and / or holder, and the positioning aid device has a technical storage medium or analog print medium with an allocation list.