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Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres and method of making same

Inactive Publication Date: 2011-01-13
FIGULY GARRET D +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0023]c) allowing the dimensionally stable, shaped article to swell and disaggregate upon exposure to a physiological aqueous fluid present in or surrounding the lumen or void, thereby forming at least partially swollen hydrogel microspheres, which totally or partially block or fill the lumen or void.

Problems solved by technology

Therefore, the problem to be solved is to provide water-swellable hydrogel microspheres in the form of a dimensionally stable article which can be formed in a variety of shapes.

Method used

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  • Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres and method of making same
  • Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres and method of making same
  • Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres and method of making same

Examples

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example 1

Preparation of a Disk-Shaped Pellet Comprised of Dried, Aggregated, Water-Swellable Hydrogel Microspheres

[0084]The purpose of this Example was to demonstrate the preparation of a disk-shaped pellet comprised of dried, aggregated, water-swellable hydrogel microspheres prepared from acrylic acid and 2-hydroxylethyl methacrylate.

[0085]Hydrogel microspheres containing 95% acrylic acid and 5% 2-hydroxylethyl methacrylate were prepared according to the method described by Figuly et al. in U.S. Patent Application Publication No. 2007 / 0237956, Example 28.

[0086]In a 150 mL preweighed, coarse fritted funnel, was added 0.503 g of the dried hydrogel microspheres. The stem of the funnel was sealed with a rubber stopper. Then, the funnel was placed on a filter flask and 150 mL of distilled water, an amount sufficient to completely swell the microspheres, was added to the funnel and its contents at room temperature. The contents were left undisturbed for 15 min. The stopper was then removed from t...

example 2

Preparation of a Disk-Shaped Pellet Comprised of Dried, Aggregated, Water-Swellable Hydrogel Microspheres

[0089]The purpose of this Example was to demonstrate the preparation of a disk-shaped pellet comprised of dried, aggregated, water-swellable hydrogel microspheres prepared from acrylic acid and 2-hydroxylethyl acrylate.

[0090]Hydrogel microspheres containing 95% acrylic acid and 5% 2-hydroxylethyl acrylate were prepared according to the method described by Figuly et al., supra, Example 31.

[0091]The dried hydrogel microspheres were suspended in water, weighed to determine swell, and then evaporatively dried as described in Example 1 to give an aggregated microsphere, disc-shaped pellet. FIGS. 2a and 2b show electron micrographs of the aggregated microsphere pellet at low and high magnification, respectively. As can be seen from the figures, the surfaces of the microspheres are integrated to some degree, resulting in a dimensionally stable pellet that can be handled without breaking...

example 3

Preparation of a Disk-Shaped Pellet Comprised of Dried, Aggregated, Water-Swellable Hydrogel Microspheres

[0092]The purpose of this Example was to demonstrate the preparation of a disk-shaped pellet comprised of dried, aggregated, water-swellable hydrogel microspheres prepared from acrylic acid.

[0093]Hydrogel microspheres containing 100% acrylic acid were prepared according to the method described by Figuly et al., supra, Example 1.

[0094]The dried hydrogel microspheres were suspended in water, weighed to determine swell, and then evaporatively dried as described in Example 1 to give an aggregated microsphere disc-shaped pellet.

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Abstract

Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres are described. The microspheres are aggregated together without the use of a binding agent. When exposed to an aqueous medium in a container, the dimensionally stable, shaped article swells slowly and disaggregates, forming at least partially swollen hydrogel microspheres, which take the shape of the container. The dimensionally stable, shaped articles disclosed herein have many potential applications, including medical applications such as a medical implant.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority under 35 U.S.C. §119 from U.S. Provisional Application Ser. No. 61 / 070201, filed Mar. 20, 2008.FIELD OF INVENTION[0002]The invention relates to hydrogel microspheres. More specifically, the invention relates to dimensionally stable, shaped articles comprised of dried, aggregated, water swellable microspheres. The shaped articles have many potential applications, including use as medical implants.BACKGROUND OF THE INVENTION[0003]Hydrogel microspheres have many potential applications, including medical applications. For example, microspheres with high density, yet a large capacity to swell in an aqueous environment, are useful for absorption applications such as small-scale spill control and for delivery applications in which they carry and release active ingredients such as fertilizers, herbicides, pesticides, cosmetics, and shampoos. Medical applications of hydrogel microspheres include tissue augmentation,...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L27/52
CPCA61L27/50A61L31/145A61L31/14A61L27/52
Inventor FIGULY, GARRET D.MAHAJAN, SURBHI
Owner FIGULY GARRET D
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