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Photonic crystal hydrogel microsphere for rapidly detecting pesticides, toxins and nano-particles, and preparation method and application thereof

A technology of photonic crystal microspheres and hydrogel microspheres, which is applied in the direction of analyzing materials through chemical reactions and observing the influence of chemical indicators on materials, etc. Displacement is difficult to observe, the color change is not large, etc., to achieve the effect of rapid non-marker detection of imprinted molecules, a large range of color change, and a simple method

Active Publication Date: 2017-12-19
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

CN 101793996 B discloses a photonic crystal film with a hydrogel inverse opal structure. The color of the film is red-shifted through the formation of ester bonds between phenylboronic acid and glucose molecules, and the recognition of glucose is realized. However, the preparation of the film is not easy to carry and detect solid imprinted molecule, which limits its application to some extent
[0004] Patent CN 102675531 A discloses a molecularly imprinted photonic crystal that can detect organophosphorus poisons. By preparing an inverse opal photonic crystal hydrogel film, the detection of organophosphorus poisons Sarin, Soman, VX and R-VX can be realized. However, judging by the change of reflection peak intensity, the displacement without reflection peak is not easy to observe
[0005] Patent CN 101279232 B discloses a method for preparing photonic crystal microspheres based on microfluidic technology. The liquid droplets of uniform size are obtained through the shearing action of the water phase and the oil phase, and the micron-sized opal structure is obtained by volatilizing the solvent at a constant temperature. The photonic crystal microspheres are suitable as drug carriers or templates; patent CN106124493 A discloses a combination of phenylboronic acid and hydrogel photonic crystal microspheres to detect glucose, glycoproteins, etc., but the reflected wave of its Bragg reflection is less than 20nm, The color change is not large enough to be recognized by the naked eye, and instrumental detection is still required to determine whether the imprinted molecules exist

Method used

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  • Photonic crystal hydrogel microsphere for rapidly detecting pesticides, toxins and nano-particles, and preparation method and application thereof
  • Photonic crystal hydrogel microsphere for rapidly detecting pesticides, toxins and nano-particles, and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0032] (1) SiO 2 Preparation of levodopa molecularly imprinted hydrogel microspheres with photonic crystal as template

[0033] A: Monodisperse 280nm SiO 2 The nanoparticles and water are formulated into a hydrosol with a mass fraction of 15%; Use a microchannel device or a syringe to shear and form uniform-sized droplets in silicone oil, and place the droplets in an oven at 60°C for 12h, SiO 2 Slowly arranged into a close-packed hexagonal opal photonic crystal structure, washed with petroleum ether several times to obtain pure SiO 2 The photonic crystal microspheres were placed in a muffle furnace and heated to 800° C. for continuous calcination for 3 hours to obtain the photonic crystal microsphere template.

[0034]B: Preparation of dopamine-containing hydrogel precursor: Weigh 0.01g of levodopa imprinted molecules, mix 4ml of methacrylic acid, 3ml of anhydrous methanol and 1ml of deionized water for 3 hours, add 2ml of ethylene glycol dimethacrylate and 0.04 g 2-hydrox...

Embodiment 2

[0040] (1) SiO 2 Preparation of Methylphosphonic Acid Molecularly Imprinted Hydrogel Microspheres Using Photonic Crystal as Template

[0041] A: Monodisperse 312nm SiO 2 The nanoparticles and water are formulated into a hydrosol with a mass fraction of 17%; Use a microchannel device or a syringe to shear in silicone oil to form droplets of uniform size, and place the droplets in an oven at 65°C for 11h, SiO 2 Slowly arranged into a close-packed hexagonal opal photonic crystal structure, washed with petroleum ether several times to obtain pure SiO 2 The microspheres were placed in a muffle furnace and heated to 700° C. for 4 hours to obtain the photonic crystal microsphere template.

[0042] B: Prepare the hydrogel precursor containing methylphosphonic acid: weigh 0.02g methylphosphonic acid, 4ml acrylic acid, 2ml absolute ethanol and 1ml deionized water and mix for 3 hours, add 2ml PEGDA 400 and 0.04g 2-hydroxy-4 -(2-Hydroxyethoxy)-2-methylpropiophenone, deoxygenated with ...

Embodiment 3

[0048] (1) Preparation of chloramphenicol molecularly imprinted hydrogel microspheres using PS / PMMA photonic crystal microspheres as a template

[0049] A: Mix monodisperse 258nm PS / PMMA nanoparticles and water to form a 15% mass fraction hydrosol; Use a microchannel device or a syringe to shear and form uniform-sized droplets in silicone oil, and place the droplets in an oven at 60°C for 24 hours. PS / PMMA slowly arranges into a close-packed hexagonal opal photonic crystal structure. After washing for one time, pure PS / PMMA microspheres were obtained. The washed PS / PMMA photonic crystal microspheres were washed three times with deionized water to obtain the photonic crystal microsphere template.

[0050] B: Prepare hydrogel precursor solution containing chloramphenicol: weigh 0.02g chloramphenicol, 3g acrylamide, 1g N-isopropylacrylamide, 3ml absolute ethanol and 1ml deionized water and mix for 3 hours, add 2ml PEGDA400 and 0.06g of 2,2-diethoxyacetophenone, deoxygenated wit...

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Abstract

A molecularly imprinted hydrogel dispersed system having self-expression characteristic, belonging to the technical field of medicine detection, is constructed at molecule, nanometer and micrometer level based on the comprehensive application of molecular imprinting, photonic crystals, sol-gel and other nanometer preparation technologies. An area to be detected is coated with photonic crystal hydrogel ink at normal temperature, and the red shift of the photon band gap of a photonic crystal hydrogel microsphere occurs and the color changes as imprinting molecules are dissolved in a solvent, so substances which can be detected with the hydrogel microsphere exist in the area to be detected. The microsphere can be applied to the detect of prohibited pesticides, toxins and heavy metal quantum dot nano-particles.

Description

Technical field: [0001] The invention belongs to the technical field of drug detection. Based on the comprehensive application of molecular imprinting, photonic crystal, sol-gel, microfluidic and other preparation technologies, a molecularly imprinted hydrogel dispersion with self-expression characteristics at the nanometer and micron levels is constructed. system, which can quickly qualitatively and semi-quantitatively detect biomolecules and nanoparticles by observing color changes, and can be applied to the detection of pesticides, toxins and nanoparticles. Background technique: [0002] Photonic crystals are formed by periodic and orderly arrangement of materials with different dielectric constants in space, which makes photonic crystals develop rapidly in the fields of fibers, mirrors, optical switches, sensors, and solar cells. Photonic crystal nanoparticles are a kind of nonlinear optical material with excellent performance. They have the characteristics of monodisper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78C08F220/06C08F222/14
CPCC08F220/06G01N21/78C08F222/102
Inventor 巍杰黄超
Owner BEIJING UNIV OF CHEM TECH
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