9 results about "Foot swelling" patented technology

The present application belongs to the technical field of medicine, and particularly relates to the use of tetrahydrojatrorrhizine or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating rheumatoid arthritis. Experimental results show that tetrahydrojatrorrhizine can effectively alleviate the foot swelling level of CIA rats, reduce the arthritis score, and inhibit the progression of rheumatoid arthritis. Blood routine analysis shows that the administration of tetrahydrojatrorrhizine reduces the number of immune cells in the blood and weakens the immune level of the body. In addition, the experimental results also show that tetrahydrojatrorrhizine can inhibit synovial hyperplasia and relieve joint damage. Therefore, tetrahydrojatrorrhizine has the prospect of being developed into an oral medicament for treating rheumatoid arthritis, provides more treatment options for clinically treating rheumatoid arthritis, and has important social and economic values.

The present invention belongs to the field of biopharmaceutical technology and specifically relates to a notoginsenoside Fe composition and its use in preparing PTGS2 protein inhibitors and drugs for preventing and treating PTGS2 diseases. The notoginsenoside Fe composition provided by the present invention is composed of notoginsenoside Fe, ginsenoside Rg5, ginsenoside Rk1, quercetin, and eriodictyol. The present invention is the first to discover a novel PTGS2 inhibitor, notoginsenoside Fe, and prepare it into a notoginsenoside Fe composition, providing a new solution for the research and development of drugs for preventing and treating PTGS2-related diseases. The notoginsenoside Fe composition provided by the present invention can reduce the levels of inflammatory factors in mice in colitis, gastritis, and arthritis models, improve colon length, and alleviate foot swelling.

The invention provides a tribenzoyl substituted vakognavine type diterpenoid alkaloid, a preparation method and application of the tribenzoyl substituted vakognavine type diterpenoid alkaloid, and a pharmaceutical composition. After rats are treated by the tribenzoyl substituted vakognavine type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

The invention provides C20 type diterpenoid alkaloid, a preparation method and application thereof and a pharmaceutical composition. After rats are treated by the C20 type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

The invention provides tetrabenzoyl substituted vakognavine type diterpenoid alkaloid as well as a preparation method, application and a pharmaceutical composition of the tetrabenzoyl substituted vakognavine type diterpenoid alkaloid. After rats are treated by the tetrabenzoyl substituted vakognavine type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

The invention provides vakognavine type diterpenoid alkaloid, a preparation method and application of the vakognavine type diterpenoid alkaloid, and a pharmaceutical composition. After rats are treated by the vakognavine type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

The utility model belongs to the technical field of shoes, and particularly relates to a diabetic foot nursing shoe which comprises a sole, an upper, an air bag and a fixing strap are arranged on the sole, the upper is composed of a foot front piece, two foot side pieces, a foot rear piece and a tongue baffle, the foot front piece is located in the front of the top end of the sole, and the air bag is arranged in the air bag. The two foot side pieces are located on the two sides of the top end of the shoe sole respectively, the foot rear piece is located on the rear portion of the top end of the shoe sole, the tongue baffle is connected with the foot front piece, the tongue baffle is provided with a through hole facilitating penetrating connection of the fixing belt, the foot front piece is provided with a first connecting ring, and the foot rear piece is provided with a second connecting ring. The first connecting ring and the second connecting ring are connected with one end of the first adjusting belt and one end of the second adjusting belt respectively, the other end of the first adjusting belt and the other end of the second adjusting belt are arranged on the foot side piece, the width of the shoe upper can be adjusted, the shoe can rapidly adapt to foot swelling of a patient, the wearing comfort of the patient in the swelling period can be improved, and the shoe is convenient to use. And the foot injury is prevented from being aggravated.

The invention discloses a pair of shoes capable of adjusting the tightness of insteps and easy to put on and take off, belongs to the technical field of shoes, and is suitable for diabetic patients, old people and other people with easily-swollen feet or limited limb movement and common users. The shoe aims at solving the problems that an existing shoe needs to be manually adjusted to be put on and taken off and is difficult to adapt to foot swelling. The technical scheme is characterized in that a vamp body is made of breathable knitted fabric; the shoe tongue is internally provided with a shape memory resin supporting piece (which is provided with a hollow area and is overlapped and sewn to form an upper warping surface body) to prevent inward rolling; a multi-curved-surface resin protective shell is embedded in the shoe heel part, so that one-step pedaling is realized, and heel falling is prevented; the instep is provided with a magic tape adjusting belt (which can be integrally or split into three independent sub-belts) with the width of 4-6cm, and the girth can be adjusted; the lining is of a buffering structure, and feet are prevented from being placed. The wearing and taking-off time is shorter than or equal to 2 seconds, the oppression disappearance rate of a diabetic patient after swelling regulation is 88%, the cost is low, mass production is easy, and convenience and comfort are achieved.

This invention relates to the field of medical device technology. To address the problems of existing ankle compression braces that cannot switch between cold and hot compress modes and cannot dynamically adjust according to the reduction of foot swelling, this invention proposes a compression patch brace for treating ankle sprains. The brace includes: a foot plate with an adjustment groove; a support plate assembly slidably positioned above the foot plate; and a patch structure embedded inside the support plate assembly, comprising a dorsum-of-the-foot airbag and an ankle airbag assembly, configured to inflate synchronously to apply pressure to the dorsum of the foot and ankle, aiding in the recovery of the sprained area. This invention enables flexible switching between cold and hot compresses, adapting to the clinical nursing needs of different rehabilitation stages of ankle sprains. Simultaneously, it can adaptively adjust the pressure according to the dynamic process of foot swelling reduction and can achieve precise positioning of the bony prominences of the ankle joint, improving the comfort and fit of the brace.