40 results about "Foot swelling" patented technology

The invention relates to an oral medicinal combination and the preparing method, using Epimedium Herb, Coix Seed, Tangerine Peel, Perilla Leaf, Common Floweringqince Fruit and other Chinese drugs as raw materials, first decocting these raw materials to extract fragrant liquid, then decocting twice and filtering, combining the filtrate, fragrant liquid and auxiliaries and making the mixture into different preparations. It can remove damp and dredge meridian, and eliminating rheumatism and stop pain, and is used to relieve joint gall of toes and metatarsi caused by gout caused by damp and corruption. In addition, the curative effect test verifies that it can prohibit joint gall of sole of the foot of a rat caused by sodium urate (MSU), remarkably reduce white cells in joint liquid of a rabit with acute arthritis induced by MSU, remarkably prohibit the foot swelling of a rat caused by carageen glue and the ear swelling of a mouse caused by dimethylbenzene, and obviously prohibit the forming of granulation swelling of a rat.

The invention provides a health food composition for promoting the health of bones and bone joints, which is a preparation made from the materials containing traditional Chinese medicine oyster and hydrolyzed collagen. Wherein, the weight ratio of the oyster and hydrolyzed collagen is: oyster 500-2000 parts and the hydrolyzed collagen 100-2000 parts. The preparation is used for preventing and treating osteoporosis, hyperosteogeny and osteoarthritis with simultaneous effect to principal and subordinate symptoms The animal tests show that: the composition of the invention has a substantial action to the model of rat osteoporosis caused by ovary resection; it also has the substantial inhibition actions to the foot swelling and adjuvant type arthritis of rat caused by carrageenan. The composition has cooperation synergism, achieves positive functions in reducing bone and joint ache, reducing brittleness and increasing bone mineral density, and is suitable for wide application.

Belonging to the field of drugs or health care products, the invention in particular relates to a gynura formosana kitam. total flavone extract, a preparation method and anti-inflammatory and analgesic use thereof. The extract contains, by weight percentage, 80-85% of rutin. The experimental result of mouse ear swelling experiments and carrageenan induced rat foot swelling experiments shows that the extract has certain anti-inflammatory effect; the experimental result of mouse hot plate experiments and acetic acid writhing experiments show that a high and middle dose of the extract can reach good analgesic effect, therefore, the gynura formosana kitam. total flavone extract provided by the invention can be used as a potential anti-inflammatory and analgesic drug. According to the preparation method of the gynura formosana kitam. total flavone extract, after an extraction step, a compound enzyme composed of specific enzymes in specific proportion is selected for enzymolysis, and furtherthrough macroporous resin extraction concentration and macroporous resin separation and purification steps, the HPLC purity of rutin in the prepared gynura formosana kitam. total flavone extract canreach 80-85%.

The present invention relates to the anti-inflammatory activity of a paeonol homologue (5-bromo-2-n-hexadecyloxy-4-methoxyacetophenone) (as shown in Figure 1) and its application in the pharmaceutical field . Paeonol homologs can significantly reduce or eliminate the inflammatory response of mouse paw swelling induced by complete Freund's adjuvant, significantly reduce the content of lipid mediators COX-2 and PGE2 in the body of inflammatory mice, and reduce the content of free radical mediator MDA. Increase the content of T-AOC and SOD. Through the anti-inflammatory activity, the present invention also provides the use of paeonol homologues in the preparation of anti-inflammatory pharmaceutical dosage forms.

The invention discloses a foot clamp plate protector and a manufacturing method thereof. The foot clamp plate protector comprises an inner foot plate matched with the inner side of the foot of the human body in size, an outer inner foot plate matched with the outer side of the foot of the human body in size and a bottom foot plate matched with the bottom of the foot of the human body in size, wherein the inner foot plate, the outer foot plate and the bottom foot plate are of mutually independent split structures. The foot clamp plate protector is a split clamp plate protector, a patient does not feel the discomfort caused by different degrees of foot swelling when the protector is used, the split clamp plate protector can be tightly bound by adopting a binding tape, and the user is not prone to a foot sprain through a mutual acting force after the protector is tightly bound by adopting the binding tape.

The invention relates to medicinal application of phillygenin, in particular to application of the phillygenin in preparing a medicine for treating arthritis, belonging to the field of medicine. The invention aims at providing an arthritis treating medicine, which takes the phillygenin as a major active ingredient; the medicine, when used for treating rheumatoid arthritis or rheumatic arthritis, has the characteristics of concrete curative effect and low adverse reaction; animal experiments show that the medicine can greatly improve the pain threshold of a rat with the arthritis and can take effects on significantly lowering a foot swelling value and reducing an inflammatory factor TNF-alpha; and the phillygenin is suitable for preparing medicines for the clinical treatment of the arthritis.

The invention provides a GAOH derivative of a new structure. The compounds have great curative effects on inflammatory bowel diseases, hepatitis viruses, foot swelling, ear swelling, arthritis, pneumonia, nephritis, rhinitis, cerebral apoplexy, myocardial ischemia, atherosclerosis, arrhythmia, autoimmune disease, senile dementia, depression, schizophrenia, malignancy and tumor adjuvant therapy, virus infectious diseases, peptic ulcer, analgesia, antianaphylaxis, antiendotoxin, antishock and diabetes or diabetic complication.

Belonging to the technical field of medicine, the invention in particular relates to application of a tetrastigma hemsleyanum comprehensive extract in preparation of drugs controlling rheumatoid arthritis. Animal experiments verify that the tetrastigma hemsleyanum comprehensive extract extracted from tetrastigma hemsleyanum can effectively alleviate the foot swelling degree of CIA mice, significantly inhibit the joint lesions of CIA mice and show good therapeutic effect, from the aspect of genetic expression, the tetrastigma hemsleyanum comprehensive extract can inhibit the expression of RORgammat and RANKLmRNA genes, thus controlling rheumatoid arthritis.

This invention is referred to the field of medicine, namely preventative treatment, and may be used as a means of synergetic minimization of negative impact of flights on human health (brain, stomach, lungs, blood vessels, heart etc.) with application of known substances and medicines with newly discovered pharmacological properties in new conditions. The ultimate technical solution of this invention would be synergetic minimization of negative impact of flying on human health without foot swelling, belching, jet-lag, tiredness and fatigue etc. The claimed technical result is achieved by the method of synergetic minimization of negative impact of air flights on human health, including consumption of substances that improve osmotic concentration of blood plasma, in the form of oral rehydration solution, split into two intakes as a minimum, first intake in the amount of at least 0.3 liters up to 1 liter before boarding and further during the flight from half an hour to 2 hours at least 0.3 liters to 1 liter and on as-needed basis.

The invention discloses a preparation method of a Herba Sambuci Adnatae extract and an application thereof in rheumatoid arthritis, and relates to the technical field of a plant extract, and a preparation method and an application thereof. The preparation method comprises the following steps: after pulverizing Herba Sambuci Adnatae, adding 5-10 times of a solvent; repeatedly extracting for 4 times at the temperature of 35-100 DEG C; and then heating a concentrated solution and carrying out freeze drying to obtain the Herba Sambuci Adnatae extract. The prepared Herba Sambuci Adnatae extract is used for treating rat rheumatoid arthritis induced by II type collagen, and the result shows that the Herba Sambuci Adnatae extract can remarkably improve level of rat foot swelling caused by the rheumatoid arthritis induced by a freund's adjuvant, the IL-6 level of a skin reaction factor in serum can be reduced remarkably, and the food intake of a rat is not affected.

The invention discloses a pharmaceutical composition for treating qi deficiency and blood stasis-type apoplexy and a preparation method thereof. The pharmaceutical composition comprises scammoniae radix, Wahlenbergia marginata, wild goose fat, euonymus bungeanus, radix artocarpi styracifolii, Pternopetalum nudicaule, madder root, corydalis amabilis, acanthopanax, Galium elegans, wild chervil, white plum flower, herba asari, gleditsia japonica, bayberry root, aquilaria wood, Limonium sinense, sweet broomwort herb, barley, areca peel, Parthenocissus tricuspidata and phoenix tree leaf as main materials and evening primrose oil, gentrin knotweed extract and phosphatidylcholine bilayer as accessory materials. The pharmaceutical composition is used for treating qi deficiency and blood stasis-type apoplexy symptoms such as hemiplegia, sluggish speech or mutistic, palpitation, loose stool and hand and foot swelling, contains the main medicinal materials with effects of tonifying qi, promoting blood circulation, dredging collaterals, removing stasis, reducing phlegm and inducing resuscitation, tonifying qi and invigorating spleen, and disinhibiting dampness and auxiliary medicinal materials with effects of adjusting blood pressure and blood fat, has good prevention and control effects on hypertension, cerebral apoplexy and heart disease, is safe, has no toxic or side effect and provides a novel drug choice for patients suffering from qi deficiency and blood stasis-type apoplexy.

The invention discloses application of cinchonain Ib to preparation of a medicament for preventing and treating rheumatoid arthritis and a healthy food for preventing rheumatoid arthritis. Experimentsshow that the cinchonain Ib can significantly inhibit the auricle swelling of mice caused by xylene and effectively relieve foot swelling of rats caused by carrageenin. An acetic acid abdominal constriction test and a hot plate test show that the cinchonain Ib has a certain analgesic effect, and the acting effect becomes more remarkable along with the acting time. Moreover, the cinchonain Ib hasa good antagonistic effect on primary plantar swelling induced by adjuvants, which indicates that the cinchonain Ib is to have a very good application prospect in the prevention and treatment of rheumatoid arthritis.

The invention provides a GAOH derivative of a new structure. The compounds have great curative effects on inflammatory bowel diseases, hepatitis viruses, foot swelling, ear swelling, arthritis, pneumonia, nephritis, rhinitis, cerebral apoplexy, myocardial ischemia, atherosclerosis, arrhythmia, autoimmune disease, senile dementia, depression, schizophrenia, malignancy and tumor adjuvant therapy, virus infectious diseases, peptic ulcer, analgesia, antianaphylaxis, antiendotoxin, antishock and diabetes or diabetic complication.

The present invention relates to the field of medicine, and provides a formula of varicose vein dredging capsules, and a production process of the varicose vein dredging capsules, wherein the varicose vein dredging capsules have effects of blood activating and blood stasis dissipating, qi regulating and blood activating, blood vessel dredging, wind-evil dispelling and dampness eliminating, stasis removing and cambium growing, analgesia, blood circulation improving, blood flow increasing, blood vessel softening, blood vessel elasticity recovering and blood return enhancing, and are used for treatment of varicosis. The varicose vein dredging capsules comprise the following drugs: achyranthes bidentata, dan-shen root, suberect spatholobus stem, combined spicebush root, clematis chinensis osbeck, rehmannia dride rhizome, white peony root, centipede, scorpion, safflower, frankincense and myrrh. After treating with the varicose vein dredging capsules, the symptoms of vein bulging, vein kinking, vein conglobating and foot swelling disappear, the treatment course is short, and the cost is low, such that the varicose vein dredging capsules of the present invention are worth to popularize.

The invention discloses Artemisia japonica homogeneous polysaccharides as well as a preparation method and an application thereof. The Artemisia japonica homogeneous polysaccharides are obtained through column chromatographic separation and purification after water extraction and alcohol precipitation of all grass of Artemisia japonica, are inulin type fructan which is connected by fructose through 1,2 and contains a glucosyl group at the terminal, contain no uronic acid and have the weight-average molecular weight ranging from 1 kDa to 20 kDa. Experiment results indicate that the Artemisia japonica homogeneous polysaccharides can obviously reduce the foot swelling degree of mice suffering from collagen-induced arthritis and levels of inflammatory factors IL-6 and IL-17A in serum of the mice, are expected to be used as a major or unique active ingredient for preparation of health-care food or pharmaceutic preparations for preventing or / and treating rheumatoid arthritis, and have the important significance in research and development of Artemisia japonica pharmaceutic preparations having the clinical application value; besides, the preparation method is simple, high-purity Artemisia japonica homogeneous polysaccharides can be obtained, and the method is suitable for large-scale production and good in practicability.

A kind of iron foot grass detoxification detumescence tea wine and its preparation method, relating to a kind of health wine, which is made of the following raw materials in parts by weight: 25-30 parts of iron foot grass, 20-25 parts of Potentilla lentils, and golden spoon leaves 15‑20 parts of Herba Grass, 13‑18 parts of Herbs, 10‑15 parts of Daphne Flower, 10‑12 parts of Baiwei Leaf, 8‑12 parts of Fenbai Chai, 7‑10 parts of Zanxinlian, 5‑8 3-5 parts of clam orchid leaves, 30-35 parts of black tea, 800-900 parts of rice wine; specific preparation process: (1) pretreatment of raw materials; (2) brewing tea; (3) mixing; (4) clarification and sterilization . The iron foot grass detoxification and swelling tea wine of the present invention can be used for long-term drinking, and can clear away heat and detoxify, promote dampness and reduce swelling, and resist inflammation and bacteria.

The invention discloses a pharmaceutical composition for preventing and curing gouty arthritis and functions thereof. The composition is made of active ingredients and auxiliary materials, wherein the active ingredients include homopterocarpin. The pharmaceutical composition can relieve foot swelling caused by gouty arthritis, reduces the content of inflammatory factors FGE2 and NO in swollen foot tissue, and accordingly relieves inflammatory reactions of the foot tissue.

The invention discloses an application of equisetin in preparation of an anti-arthritis drug. The content of the equisetin is greater than or equal to 0.1 [mu] M. A transdermal absorption preparationprepared by taking the equisetin as a raw material has the characteristic of direct and remarkable inhibition effect on carrageenan-induced acute arthritis, is good in treatment effect, can be used for effectively relieving foot swelling of mice, and can be used for treating arthritis and other related diseases. Moreover, the preparation can also effectively inhibit the expression of inflammatoryfactors IL-1, IL-6 and TNF-alpha, reduce the content of inflammatory factors in serum and reduce inflammation. The preparation is externally and directly applied to an affected part, is convenient touse and has extremely high use value.

The invention relates to anti-inflammatory activity of a paeonol homolog (5-bromo-2-n-hexadecyloxy-4-methoxyacetophenone) as shown in figure 1, and application of the paeonol homolog in the field of pharmacy. The paeonol homolog can obviously mitigate or eliminate the inflammatory response, i.e., foot swelling, of mice induced by complete Freund's adjuvant, obviously reduce the contents of lipid mediums COX-2 and PGE2 in the mice with inflammations, decrease the content of a free radical medium MDA and increase the contents of T-AOC and SOD. The invention also provides application of the paeonol homolog in preparation of an anti-inflammatory dosage form.

The invention provides a medicine for treating damp-heat foot swelling of a duckling. Every 100g of the medicine is prepared from 3g of rhizoma atractylodis, 2g of talc, 3g of cortex phellodendri, 1g of rhizoma acori graminei, 1g of radix achyranthis bidentatae, 15g of Chinese granesbill, 15g of herba aleuritopteris subvillosa, 6g of herba juncus bufonius, 30g of root or stem of delavay rockvine, 15g of Omei Mountain bambusa, 30g of herba monochoria vaginalis, 3g of root of ampelopsis japonica, 5g of radix scutellariae and 12g of flos chrysanthemi indici. When the rhizoma atractylodis, the talc, the cortex phellodendri and the rhizoma acori graminei are prepared, impurities are picked out, and the raw barks are scraped; when being used, the rhizoma atractylodis, the talc, the cortex phellodendri and the rhizoma acori graminei are smashed, or the raw barks are scraped, and then the rhizoma atractylodis, the talc, the cortex phellodendri and the rhizoma acori graminei are soaked in warm boiled water for a while, then sliced and dried in the air. The medicine can radically treat the symptom of damp-heat foot swelling of the duckling without causing side effects; through cooperation of the rhizoma atractylodis, the cortex phellodendri and the rhizoma acori graminei, blood circulation can be promoted, the metabolism is accelerated, the dead cells on the surface are removed, and the heat is cleared, the dampness is dried, the wind is dispelled and the toxin is removed; additionally, since the properties of clearing heat and removing toxicity of the herba monochoriae vaginalis, the root of ampelopsis japonica, the radix scutellariae and the flos chrysanthemi indici, the symptom of damp-heat foot swelling of the duckling is effectively treated.

The invention relates to a preparation method of a honeysuckle leaf anti-inflammatory active component. The preparation method comprises the following steps: 1) performing petroleum ether degreasing treatment on the crushed dry honeysuckle leaves and performing reflux extraction by using methanol to obtain a viscous crude extract; 2) dissolving the viscous crude extract by using secondary water toobtain suspension, extracting by using normal butanol and performing reduced-pressure concentration to obtain a normal butanol phase; and 3) performing column chromatography isolation on the normal butanol phase, eluting by using a methanol aqueous solution of 10 percent, 20 percent, 30 percent, 40 percent, 50 percent, 60 percent and 70 percent separately, and eluting the obtained fraction by selecting a methanol aqueous solution of 50 percent. Through research on the inhibition effect of 5-LOX, research on the anti-inflammatory effect of a mouse macrophage system RAW264.7 and research on theanti-inflammatory effect of rat foot swelling, the invention discovers that the honeysuckle leaf anti-inflammatory active component (M1) has excellent anti-inflammatory activity and can provide theoretical basis for the research and development of the anti-inflammatory medicine.

Disclosed is a shoe including a sole and an upper, wherein the upper includes an inner upper and an outer upper, wherein the inner upper includes 90% or more of a wool fiber and the outer upper includes a combination of 50 to 80% by weight of the wool fiber and 20 to 50% by weight of a synthetic fiber, based on the total weight of the outer upper.The shoe according to the present invention can facilitate discharge of sweat generated during exercise through the upper made of natural wool fiber and thus offer fresh wear sensation and can be worn without socks. In addition, elasticity of wool fabric can reduce resistance of shoes depending on shape change of feet during exercise or in a daily life, thus impairing foot comfort. As a result, people whose feet swell readily, such as pregnant women, can wear the shoes without irritation. Furthermore, the shoes according to the present invention are suitable for diabetic patients whose feet need to be protected from injury because they are made of wool which is a soft elastic fiber.

The invention discloses red bean yoghourt containing rice embryo and a preparation method thereof, and belongs to the technical field of food processing. The red bean added in the yoghourt is rich inprotein, vitamin B and various minerals, foot swelling can be prevented and treated when eating many of the red beans, and the crystal soda of the red bean can also increase gastrointestinal peristalsis, reduce constipation, promote urination, and eliminate edema caused by heart or kidney diseases. Besides, the red bean yoghourt is a combination of animal and plant proteins, so that the nutritioncomplementation is achieved; the rice embryo contains abundant protein, fat and vitamin E, can prevent the deposition of cholesterol in blood vessels and prevent diabetes, and the rice embryo has a better anti-aging effect due to the abundant vitamin E. The red bean yoghourt containing the rice embryo has the dual functions of nutrition and health, enriches the flavors of the yoghourt, has the market development prospect, and can promote the development of the dairy product industry.

The invention discloses an aristolic acid derivative and application thereof in preparation of anti-inflammatory drugs. Experiments prove that the aristolic acid derivative can remarkably inhibit foot swelling of rats caused by carrageenan and can obviously reduce the amount of pleurisy pleural exudate and leukocyte migration of the rats caused by carrageenan. Therefore, the aristolic acid derivative disclosed by the invention has a remarkable anti-inflammatory effect, can be used for preparing anti-inflammatory drugs, and shows good application and development prospects.

The invention discloses a multifunctional outdoor breathable sports shoe in the technical field of boots. The multifunctional outdoor breathable sports shoe comprises a sole, an inner vamp and an outer vamp, the sole is fixedly connected to the bottom of the inner vamp, a plurality of breathable holes are formed in the two sides and the top of the inner vamp, toe openings are formed in the positions, close to toes, of the inner vamp, and the outer vamp wraps the outer side of the inner vamp; the bottom of the outer side of the outer vamp is wrapped by first wrapping cloth, the bottom of the first wrapping cloth is fixedly connected with a rubber strip, the inner side of the rubber strip is fixedly connected with a first son hook-and-loop fastener, the first son hook-and-loop fastener is provided with a first mother hook-and-loop fastener in an adhesive mode, the first mother hook-and-loop fastener is fixedly connected to the outer side of the sole and a zipper strip is arranged on the outer vamp close to the heel. The problems that feet often feel cold when wearing existing sports shoes with a good ventilation effect in winter, sports shoes with a poor ventilation effect fail to volatilize foot sweat of a user in summer, foot odor and beriberi are caused if the foot sweat is light, foot swelling is possibly caused if the foot sweat is serious, and the use feeling of a user is severely reduced are solved.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a prinsepiol sublingual tablet and a preparation method thereof. The prinsepiol sublingual tablet comprises 1-10 parts of prinsepiol cyclodextrin inclusion, 15-20 parts of filling agent, 1-5 parts of polyethylene glycol 400, 1-6 parts of disintegrant, 1-5 parts of corrigent and 0.5-5 parts of lubricant. Application of prinsepiol in preparing medicine compositions with antipyretic, analgesic and anti-inflammatory functions is provided for the first time. It is proved through a mouse hot plate method and rat carrageenin caused foot swelling experiments that prinsepiol has excellent antipyretic and anti-inflammatory functions. The novel preparation of the prinsepiol sublingual tablet is provided for the first time, the formula is reasonable, the dissolution rate, the disintegration degree and stability tests meet the requirements, and the excellent antipyretic and anti-inflammatory effects are obtained; the prinsepiol sublingual tablet is very convenient to use, is taken by a patient sublingually, is high in compliance and can reduce the pressure of conventional tablet taking, andthe sublingual tablet makes people have an psychological effect of enhancing the antipyretic and anti-inflammatory functions.