6 results about "Foot swelling" patented technology

The present application belongs to the technical field of medicine, and particularly relates to the use of tetrahydrojatrorrhizine or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating rheumatoid arthritis. Experimental results show that tetrahydrojatrorrhizine can effectively alleviate the foot swelling level of CIA rats, reduce the arthritis score, and inhibit the progression of rheumatoid arthritis. Blood routine analysis shows that the administration of tetrahydrojatrorrhizine reduces the number of immune cells in the blood and weakens the immune level of the body. In addition, the experimental results also show that tetrahydrojatrorrhizine can inhibit synovial hyperplasia and relieve joint damage. Therefore, tetrahydrojatrorrhizine has the prospect of being developed into an oral medicament for treating rheumatoid arthritis, provides more treatment options for clinically treating rheumatoid arthritis, and has important social and economic values.

The invention provides a tribenzoyl substituted vakognavine type diterpenoid alkaloid, a preparation method and application of the tribenzoyl substituted vakognavine type diterpenoid alkaloid, and a pharmaceutical composition. After rats are treated by the tribenzoyl substituted vakognavine type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

The invention provides C20 type diterpenoid alkaloid, a preparation method and application thereof and a pharmaceutical composition. After rats are treated by the C20 type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

The invention provides tetrabenzoyl substituted vakognavine type diterpenoid alkaloid as well as a preparation method, application and a pharmaceutical composition of the tetrabenzoyl substituted vakognavine type diterpenoid alkaloid. After rats are treated by the tetrabenzoyl substituted vakognavine type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

The invention provides vakognavine type diterpenoid alkaloid, a preparation method and application of the vakognavine type diterpenoid alkaloid, and a pharmaceutical composition. After rats are treated by the vakognavine type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

This invention relates to the field of medical device technology. To address the problems of existing ankle compression braces that cannot switch between cold and hot compress modes and cannot dynamically adjust according to the reduction of foot swelling, this invention proposes a compression patch brace for treating ankle sprains. The brace includes: a foot plate with an adjustment groove; a support plate assembly slidably positioned above the foot plate; and a patch structure embedded inside the support plate assembly, comprising a dorsum-of-the-foot airbag and an ankle airbag assembly, configured to inflate synchronously to apply pressure to the dorsum of the foot and ankle, aiding in the recovery of the sprained area. This invention enables flexible switching between cold and hot compresses, adapting to the clinical nursing needs of different rehabilitation stages of ankle sprains. Simultaneously, it can adaptively adjust the pressure according to the dynamic process of foot swelling reduction and can achieve precise positioning of the bony prominences of the ankle joint, improving the comfort and fit of the brace.