The invention relates to the technical field of medical assistant equipment and discloses a prone position operation face position adjusting device which comprises a base, wherein the base comprises arod I, a rod II, a rod III and a rod IV; and the base is provided with a forehead pad, a lower jaw pad, face pads, side pads, a groove, support plates, lifting devices, support blocks, threaded rods,knobs, limiting round blocks, sliding tracks and sliding rods. The device is applicable to patients of which lengths and widths of faces are different, the purpose that different parts on the faces are alternatively pressed in the operation process is achieved, and skin pressure damage caused by long-term continuous stressing of a same stressed part can be effectively prevented; and meanwhile, the device is applicable to patients of different shapes and convex arches of corresponding parts of faces, the stressing uniformity of different parts of the faces can be further improved, and the comfort of the patients can be improved.