The invention relates to a radial artery puncture fixing compression plate which comprises a plate body. The plate body comprises an arm plate and a hand plate, and the position, between the end portion of the arm plate and the arm plate, of the hand plate is in a bending shape. According to the radial artery puncture fixing compression plate, the two ends of a wrist joint are fixed through the hand plate and the arm plate respectively, and an optimal puncture body position is provided for the wrist joint before puncture so that the success rate of radial artery puncture can be improved; the optimal body position of the wrist joint is maintained in the monitoring process, pipeline bending is reduced, one more body position adjustment and one more puncture needle fixation are reduced in the monitoring process, and interference with blood pressure monitoring and operations is reduced. The arm plate is provided with a detachable compression block, after sufficient gas is filled when radial artery pressure measuring is completed, a compression air bag and the compression block are matched so that a compression puncture point with proper pressure can be provided, personnel waste is reduced, the pressure is more stable and suitable, air bag soft compression can be achieved, the pressure is even, bruising can be avoided, the compression effect is better, cross infection caused by repeated usage is avoided, the applied range is wide, and safety and reliability are achieved.