A 
catheter and 
patch electrode system is provided for use with an apparatus, such as an 
ablation generator, having a 4-wire interface for improved impedance measurement. The 4-wire interface includes a pair of source connectors across which an 
excitation signal is produced and a pair of sense connector wires across which the impedance is measured. The 
RF ablation generator may also produce an 
ablation signal across a source wire and an indifferent return 
patch electrode. The 
system further includes a cable that connects the generator to a 
catheter. The 
catheter includes a shaft having a proximal end and a distal end, with an 
ablation tip 
electrode disposed at the distal end. A source lead is electrically coupled to the tip 
electrode and extends through the shaft to the proximal end where it is terminated. An optional sense lead is also electrically coupled to the tip 
electrode and extends through the shaft to the proximal end. The 
system further includes a source return (e.g., 
skin patch) and a sense return (e.g., 
skin patch), either or none of which may be combined with the indifferent return, and if used may be placed on opposite sides of the patient for 
improved performance. The 
impedance sensor circuit produces an 
excitation signal across the source connectors, which is then carried to the catheter by the cable, then to the tip electrode, travels through the complex load (
tissue volume), and returns to the generator via a 
patch electrode. The impedance is measured by observing the 
voltage drop across the sense connectors caused by the 
excitation signal.