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169results about How to "Reduce local pressure" patented technology

Solution formulations of sirolimus and its analogs for CAD treatment

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
Owner:WYETH LLC

Injectable formulations of taxanes for cad treatment

InactiveUS20050272806A1Minimize potential risk of damageReduce frictionBiocideOrganic active ingredientsAntioxidantBlood vessel
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices. Liquid formulations, including solutions and suspensions of the various drugs, agents and/or compounds, may be locally or regionally delivered. In each of these instances, antioxidants are utilized to prolong product integrity.
Owner:CARDINAL HEALTH SWITZERLAND 515 GMBH

Local vascular delivery of cladribine in combination with rapamycin to prevent restenosis following vascular injury

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
Owner:WYETH LLC

Thrombectomy and tissue removal method

A device for removing a thrombus or other tissue deposit from the cardiovascular system, natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one jet at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet(s) is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet(s) can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the tip of the catheter.
Owner:MEDRAD INC.

Trailing arm suspension with optimized I-beam

ActiveUS7484744B2Reduces amount of contactReduce amount of flexureBearing componentsInterconnection systemsVehicle frameTrailing arm
A suspension system for suspending a vehicle frame above a plurality of ground-engaging wheels includes a wheel-carrying axle comprising a first end a second end, and a pair of frame bracket assemblies each comprising a resiliently-bushed pivotable connection defining a pivot axis, wherein the frame bracket assemblies are operably coupled to opposite sides of the frame bracket, and wherein the resiliently-bushed pivotable connection comprises a substantially cylindrically-shaped bushing. The suspension system also includes a pair of trailing arms each comprising a first end operably coupled to the first end and the second end of the axle, respectively, and a second end comprising an aperture that receives the bushing of one of the frame bracket assemblies therein, wherein the aperture of the second end of each trailing arm is nonsymmetrical, thereby causing a nonsymmetrical compression of the bushing about the pivot axis. The suspension system also includes embodiments wherein the aperture of the second end of each trailing arm is nonuniform, thereby reducing rotation of the bushing with respect to the trailing arm, wherein a mating surface of each trailing arm operably coupled to the first and second end of the axle comprise a cavity, thereby reducing a localized stress transferred from the trailing arm to the axle, wherein the second end of each trailing arm further comprises a lip extending radially outward from the aperture and at least one engagement surface extending radially outward from the lip and adapted to abut a bushing-removal tool, as well as other improvements.
Owner:THE HOLLAND GROUP

Self-propelled drilling method and pulsed cavitation swirling jet nozzle

The invention relates to a self-propelled drilling method and a nozzle. The self-propelled drilling method is formed by coupling a pulsed jet method, a cavitation jet method and a swirling jet method, wherein, an impeller body arranged in the nozzle can rotate under the impact action of a fluid, a part of forward jet orifices arranged at the head of the nozzle as well as a part of backward jet orifices which are arranged on the nozzle and are opposite to the forward jet orifices can be closed during the rotation process of the impeller body, the fluid is ejected from the other part of the forward jet orifices and the backward jet orifices so as to form jet flow, and the forward jet orifices are alternately closed so as to generate pulsed jet during the rotation process of the impeller body; the fluid entering the nozzle is driven to rotate by the rotating impeller body, and then the rotating fluid is ejected from the jet orifices so as to generate swirling jet; and the central pressure in the nozzle can be reduced by means of rotation of the impeller body so as to form cavitation jet. In the self-propelled drilling method, advantages of the three types of jet flow are integrated so as to greatly improve the drilling efficiency; and the self-propelled drilling method and the nozzle are applicable to drilling holes in a ground layer.
Owner:CHINA UNIV OF PETROLEUM (BEIJING)

Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
Owner:WYETH LLC
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