Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

32 results about "Electron micrographs" patented technology

An electron micrograph of a microsopic dust mite, which feeds off the dead skin of humans and animals. The accompanying electron micrograph shows good distribution of the silica particles.

Method for evaluating porosity of mud shale at objective layer segment

The invention relates to a method for evaluating the porosity of mud shale at an objective layer segment, and belongs to the technical field of exploration and development of petroleum, geology and mining industry. The method can be used for evaluating the total porosity, the organic porosity and the inorganic porosity of the mud shale at the objective layer segment in a shale gas well. The method comprises the following steps: (1) determining the mass of various ingredients in a mud shale sample skeleton in unit mass at each depth point of the objective layer segment and the density of each dried sample block body and calculating the total porosity of the mud shale in all the depth points via the combination of the actual density of various minerals; (2) calculating the organic porosity (Phi organic') formed by the hydrocarbon generation of the mud shale at the objective layer segment by utilizing chemical kinetics; (3) seeking a solution of the organic porosity (Phi organic) according to scanning electron micrographs of multiple argon ion polishing samples in the same depth point; (4) calibrating the organic porosity (Phi organic') calculated according to the chemical kinetics by utilizing the organic porosity (Phi organic); and (5) seeking a solution of the inorganic porosity by utilizing a difference value of the total porosity and the calibrated organic porosity.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)

Automatic measurement method for separated-out particles in steel and morphology classification method thereof

The invention discloses an automatic measuring and morphological classification method for particles precipitated from steel, comprising the steps as follows: firstly, the electron micrographs of the target particles precipitated from steel are subjected to image binary segmentation so as to obtain the binary images of the particles; the binary images of the target particles are denoised by a morphological filtering method, a seed filling method is adopted to fill holes, and the particles to be separated are determined by the domain value determined by experience criterion and the separation of agglomerate particles is carried out; the particles after separation are subjected to region labeling; finally, the neural network morphological classification models of the target particles precipitated from steel are established; and results are displayed and output in the form of graph files. The method can obtain ideal measuring and classification effect without omission inspection and re-inspection; the measurement accuracy of particle size can reach plus or minus 2 microns, the particle size distribution anastomotic rate can be more than 91.7 percent, and the anastomotic rate of morphological classification can be more than 90.5 percent; the particle measuring and classification of one view field cost only a few minutes; and the method has excellent universality and can be used in all the particle measuring and classification works with complex backgrounds and morphologies in the material field and biological field.
Owner:JIANGSU UNIV

Expandable polystyrenic resin particles and production process thereof, pre-expanded particles and molded foam product

Expandable polystyrenic resin particles having superior resistance to cracking of a molded foam product, having superior retention of blowing agent and maintaining expandability over a long period of time, a production process thereof, and a molded foam product are provided. These expandable polystyrenic resin particles contain a volatile blowing agent in polystyrenic resin particles obtained by impregnating and polymerizing a styrenic monomer in polyolefin resin particles to form a polystyrenic resin, wherein together with the styrenic monomer being used at 140 to 600 parts by weight to 100 parts by weight of the polyolefin resin particles, the average thickness of the surface layer observed in scanning electron micrographs obtained by immersing sections cut into halves through the center from the surface of the resin particles in tetrahydrofuran followed by extracting the polystyrenic resin component and capturing cross-sections of said sections is 15 to 150 μm, and the volatile blowing agent is contained at 5.5 to 13.0% by weight.
Owner:SEKISUI PLASTICS CO LTD

Identification and classification of virus particles in textured electron micrographs

The method is for the identification and characterization of structures in electron micrographs. Structures in a first image are selected. The structures have a first shape type deformed in a first direction. The selected structures are transformed to a second shape type different from the first shape type. The transformed structures of the second shape type are used to form a plurality of templates. A new structure in a second image is identified. The new structure has the first shape type. The second shape type structure of each template is deformed in the first direction. It is determined which template is a preferred template that best matches the new structure.
Owner:INTELLIGENT VIRUS IMAGING

Material for producing slab of semiconductor chip, preparation method and application thereof

The invention relates to a material for producing a slab of semiconductor chip, a preparation method and an application thereof. The material for producing the slab of semiconductor chip disclosed in the invention has s sandwich structure, wherein, a middle layer of the sandwich structure is composed of a semiconductor chip to be examined, layers at two sides of the sandwich structure are composed of Si substrate wafers, a binder used for binding inorganic nonmetallic materials is adopted to bind the middle layer and the layers at two sides of the sandwich structure. The invention further provides the preparation method for preparing the material for producing a slab of semiconductor chip, and the application of the material for producing a slab of semiconductor chip in producing the slab of semiconductor chip. The material for producing the slab of semiconductor chip prepared by the method disclosed in the invention has good observation effect of electron micrographs, and can be prepared without mold or resins. Because section area of grinding and polishing is small, the consumption of materials in grinding and polishing is reduced, the production time of a sample is short, the production cost of the sample is low, and wastes in the preparing process can be minimized.
Owner:PEKING UNIV FOUNDER GRP CO LTD +1

Polycarbonate Resin Composition and Molded Product Produced from the Same

The present invention relates to a polycarbonate resin composition having an excellent weld strength. The polycarbonate resin composition comprises:100 parts by weight of a mixture comprising (a) 60 to 95 parts by weight of an aromatic polycarbonate resin, (b) 4 to 39 parts by weight of a styrene / (meth)acrylonitrile-based copolymer produced by polymerizing at least a styrene-based monomer and a (meth)acrylonitrile-based monomer with each other in the presence of a rubber, and (b′) 1 to 36 parts by weight of a styrene / (meth)acrylonitrile-based copolymer produced by polymerizing at least a styrene-based monomer and a (meth)acrylonitrile-based monomer with each other in the absence of the rubber;0 to 40 parts by weight of a phosphorus-based flame retardant (c);0 to 5 parts by weight of a fluorinated polyolefin (d) and0 to 50 parts by weight of an inorganic filler (e), which (c), (d) and (e) are blended to the 100 parts by weight of the mixture in respective amount,the polycarbonate resin composition satisfying the following relational formula (1):Sg / (Sd / B2 / 3)≧0.5  (1)wherein B is a weight ratio (% by weight) of a sum of the components (b) and (b′) to a sum of the components (a), (b) and (b′) ((b+b′) / (a+b+b′)); Sd is an average occupation area (μm2) of a styrene / (meth)acrylonitrile-based copolymer domain (hereinafter referred to merely as an “AS domain”) dispersed in a polycarbonate resin matrix; and Sg is an average occupation area (μm2) of rubber particles dispersed in the AS domain in which Sd and Sg are values measured by subjecting an electron micrograph of the composition to image processing.
Owner:MITSUBISHI ENG PLASTICS CORP

Preparation method of hexagonal prism zinc oxide

InactiveCN109987623AFlat surfaceRealize controllable synthesis technologyZinc oxides/hydroxidesElectron micrographsFiltration
The invention discloses a preparation method of hexagonal prism zinc oxide. The preparation process of the method comprises the following steps: (1) taking a certain volume of deionized water and an ethylene glycol solution, and performing ultrasonic dispersion so as to obtain a mixed solution; (2) adding a zinc oxide precursor and a morphology control agent sequentially to the mixed solution, andperforming ultrasonic dissolution; (3) transferring the mixed solution to a hydrothermal kettle, and performing a reaction at high temperature for a period of time; (4) performing suction filtration,performing washing with ethanol, and performing drying at a high temperature; and (5) performing high-temperature calcination on the dried product finally. It can be seen through comparison with zincoxide X-ray diffraction standard cards that the product is a hexagonal crystal zinc oxide crystal, and at the same time, it can be clearly seen from field emission scanning electron micrographs thatthe product is of a hexagonal prism. The preparation method has the advantages that 1, hexagonal crystal prism zinc oxide particles with asymmetric morphology are obtained, 2, the zinc oxide crystal exposes different crystal faces, and the controllable crystal plane is key to application of zinc oxide.
Owner:EAST CHINA UNIV OF SCI & TECH

Productivity and Bioproduct Formation in Phototropin Knock/Out Mutants in Microalgae

Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these processes include phototropism, chloroplast movement and stomatal opening. In the green alga Chlamydomonas reinhardtii, phototropin plays a vital role in progression of the sexual life cycle and in the control of the eye spot size and light sensitivity Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out (PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown cultures (500 μmol photons m−2 s−1). Our results indicate the up-regulation of genes involved in photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1,5-bisphosphate carboxylase / oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in starch and lipid synthesis. In addition, transmission electron micrographs show increased accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a pond environment. In conclusion, our studies suggest that phototropin may be a master gene regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in wild type strains.
Owner:NMC INC +1

Method for preparing micro-nano hole cobalt nickel alloy

Cobalt nickel alloy is a shape memory alloy which has super-elasticity and high damping characteristic, is remarkable in effects when being applied to the aspects of vibration control and noise control, and can be widely applied to the fields of high and new technologies such as navy sonar, a high-performance sensor, a micro-robot, microwave communication, intelligent devices and the like. The invention relates to a simple chemical method for preparing a series of cobalt nickel porous alloy having the aperture size scale within the micro-nano level; and the test result shows that the alloy is pure cobalt nickel, and the scanning electron micrograph shows that the series of product has a reticular three-dimensional structure and the hole size within the range of about 1-10 microns, so that compared with the porous alloy which is synthesized by other scholars and has the aperture size scale of about 100 microns, the cobalt nickel porous alloy has the aperture size scale which is reduced by one or two order(s) of magnitude. Due to the larger porosity and micro-nano aperture, the cobalt nickel porous alloy is ensured to have the characteristics of light weight and high strength; and due to the hollow linked micro-nano detail structure, the interior of the cobalt nickel porous alloy has larger extra superficial area, and the super-elasticity and the high damping characteristic of the cobalt nickel porous alloy are remarkably improved.
Owner:BEIHANG UNIV

Multilayered structure

[Problems] To provide a multilayered structure which eliminates the need of providing any particular adhesive layer, enables the ethylene / vinyl alcohol copolymer to exhibit excellent oxygen-barrier property to a sufficient degree, and can be effectively used even when a polyolefin resin is used as the inner and outer layers.[Means for Solution] A multilayered structure having an adhesive intermediate layer of a blend of an ethylene / vinyl alcohol copolymer (A) and a maleic anhydride-modified olefin resin (B) between an inner layer and an outer layer, the adhesive intermediate layer containing the ethylene / vinyl alcohol copolymer (A) and the maleic anhydride-modified olefin resin (B) at a weight ratio of 4:6 to 8:2, the phase structure of the adhesive intermediate layer being a sea-island structure with the maleic anhydride-modified olefin resin (B) as the sea or being a bicontinuous phase, and the adhesive intermediate layer having a standard deviation of not less than 65 when a contrast profile of the ethylene / vinyl alcohol copolymer (A) and the maleic anhydride-modified olefin resin (B) in the adhesive intermediate layer near the interface thereof is numerically expressed on a scanning electron microphotograph of the cross section of the multilayered structure in the direction of thickness by using an image analysis software.
Owner:TOYO SEIKAN KAISHA LTD

Metrology of semiconductor devices in electron micrographs using fast marching level sets

Apparatuses and methods for metrology on devices using fast marching level sets are disclosed herein. An example method at least includes initiating a fast marching level set seed on an image, propagating a fast marching level set curve from the fast marching level set seed to locate boundaries of a plurality of regions of interest within the image, and performing metrology on the regions of interest based in part on the boundaries.
Owner:FEI CO

A method for evaluating the porosity of shale in the target interval

The invention relates to a method for evaluating the porosity of mud shale at an objective layer segment, and belongs to the technical field of exploration and development of petroleum, geology and mining industry. The method can be used for evaluating the total porosity, the organic porosity and the inorganic porosity of the mud shale at the objective layer segment in a shale gas well. The method comprises the following steps: (1) determining the mass of various ingredients in a mud shale sample skeleton in unit mass at each depth point of the objective layer segment and the density of each dried sample block body and calculating the total porosity of the mud shale in all the depth points via the combination of the actual density of various minerals; (2) calculating the organic porosity (Phi organic') formed by the hydrocarbon generation of the mud shale at the objective layer segment by utilizing chemical kinetics; (3) seeking a solution of the organic porosity (Phi organic) according to scanning electron micrographs of multiple argon ion polishing samples in the same depth point; (4) calibrating the organic porosity (Phi organic') calculated according to the chemical kinetics by utilizing the organic porosity (Phi organic); and (5) seeking a solution of the inorganic porosity by utilizing a difference value of the total porosity and the calibrated organic porosity.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)

Automatic measurement method for separated-out particles in steel and morphology classification method thereof

The invention discloses an automatic measuring and morphological classification method for particles precipitated from steel, comprising the steps as follows: firstly, the electron micrographs of the target particles precipitated from steel are subjected to image binary segmentation so as to obtain the binary images of the particles; the binary images of the target particles are denoised by a morphological filtering method, a seed filling method is adopted to fill holes, and the particles to be separated are determined by the domain value determined by experience criterion and the separation of agglomerate particles is carried out; the particles after separation are subjected to region labeling; finally, the neural network morphological classification models of the target particles precipitated from steel are established; and results are displayed and output in the form of graph files. The method can obtain ideal measuring and classification effect without omission inspection and re-inspection; the measurement accuracy of particle size can reach plus or minus 2 microns, the particle size distribution anastomotic rate can be more than 91.7 percent, and the anastomotic rate of morphological classification can be more than 90.5 percent; the particle measuring and classification of one view field cost only a few minutes; and the method has excellent universality and can be used in all the particle measuring and classification works with complex backgrounds and morphologies in the material field and biological field.
Owner:JIANGSU UNIV

Multilayered structure

Provided is a multilayered structure that can make full use of the excellent oxygen-barrier properties of an ethylene / vinyl-alcohol copolymer without the provision of a separate adhesive layer, and can be effectively applied even when a polyolefin resin is used for inner and outer layers. The multilayered structure is provided with an adhesive middle layer between inner and outer layers, said adhesive middle layer comprising a blend of an ethylene / vinyl-alcohol copolymer (A) and a maleic anhydride modified olefin resin (B) mixed using a weight ratio between 4:6 and 8:2. The phase structure of the adhesive middle layer is either a sea-island structure with the maleic anhydride modified olefin resin (B) as the sea, or a bicontinuous phase. Using a scanning electron microscope to take a cross-sectional micrograph across the thickness of the multilayered structure, and using image-analysis software to quantify the contrast distribution in the neighborhood of phase boundaries between the ethylene / vinyl-alcohol copolymer (A) and the maleic anhydride modified olefin resin (B) in the adhesive middle layer, the standard deviation is at least 65.
Owner:TOYO SEIKAN KAISHA LTD

Printed makeup product and makeup method

The printed makeup product of the present invention includes a base sheet 1, an inorganic solid layer 3 provided on the base sheet, and an ink-jet printed image 5 formed on the inorganic solid layer 3. A makeup material is applied onto the ink-jet printed image 5. The surface of the inorganic solid layer 3, upon observation in an electron micrograph at a magnification of 100, is a rough surface where indefinitely shaped protrusions are present in a proportion of 10 to 30% per unit area. Of the indefinitely shaped protrusions, 50 to 300 of them per mm2 are observed having a major diameter of 10 to 300 μm.
Owner:TOKUYAMA CORP

Productivity and Bioproduct Formation in Phototropin Knock/Out Mutants in Microalgae

Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these processes include phototropism, chloroplast movement and stomatal opening. In the green alga Chlamydomonas reinhardtii, phototropin plays a vital role in progression of the sexual life cycle and in the control of the eye spot size and light sensitivity Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out (PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown cultures (500 μmol photons m−2s−1). Our results indicate the up-regulation of genes involved in photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1,5-bisphosphate carboxylase / oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in starch and lipid synthesis. In addition, transmission electron micrographs show increased accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a pond environment. In conclusion, our studies suggest that phototropin may be a master gene regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in wild type strains.
Owner:TRIAD NAT SECURITY LLC +1

Method for automated unsupervised ontological investigation of structural appearances in electron micrographs

The method is for dividing dark objects, substructures and background of an image from an electron microscope into segments by analysing pixel values. The segments are transformed and aligned so that the transformed objects, sub-structures and background are meaningfully comparable. The transformed segments are clustered into classes which are used for ontological investigation of samples that are visualized by using electron microscopy. A triangle inequality comparison can be used to further cluster groups of objects to transfer understanding from different interactions between objects and to associate interactions with each other.
Owner:INTELLIGENT VIRUS IMAGING

ABS based resin and its prepn method

A molding of an ABS-based resin has rubber particles located at a depth of 0.5-1.5 mu m from a surface of the molding, and the particles morphologically comprise at least the following two types of particles: (1) A particles having an a / b ratio not greater than 1.5, wherein a and b represent a major axis and a minor axis, respectively, and (2) B particles having an a / b ratio not smaller than 5, wherein a and b have the same meanings as defined above. When a section taken by a microtome in parallel with a surface of the molding is observed in an electron micrograph, and assuming that the total area of the rubber particles as observed in the electron micrograph is 100%, the total area of the A particles accounts for at least 10% and that of the B particles is in a range of 0.01-90%.
Owner:MITSUI CHEM INC

Analysis method for internal holes of powder particles

The invention discloses a method for analyzing internal holes of powder particles, and belongs to the technical field of analysis. The analysis method comprises the following steps: mixing to-be-detected powder and an embedding medium, and preparing to obtain a cured sample; determining an observation surface of the cured sample, and carrying out argon ion polishing treatment on the observation surface; observing the observation surface subjected to argon ion polishing by using a scanning electron microscope, and randomly shooting the observation surface in a set view field to obtain a plurality of scanning electron microscope images; analyzing the plurality of scanning electron micrographs to obtain parameters related to the properties of the holes so as to analyze the internal holes of the powder particles; the parameters comprise the total number of powder particles in a plurality of scanning electron micrographs, the total number of holes in the plurality of scanning electron micrographs, the sum of the diameters of all the holes, the average diameter of the holes, the total number of the particles with the holes in the plurality of scanning electron micrographs, the sum of the diameters of all the particles with the holes and the average diameter of the particles with the holes. The method is suitable for quantitative and qualitative analysis of internal holes of powder particles with the particle size of 2-10 [mu] m.
Owner:BC P INC CHINA NAT PETROLEUM CORP +2

Using convolution neural networks for on-the-fly single particle reconstruction

Convolutional neural networks (CNNs) of a set of CNNs are evaluated using a test set of images (electron micrographs) associated with a selected particle type. A preferred CNN is selected based on theevaluation and used for processing electron micrographs of test samples. The test set of images can be obtained by manual selection or generated using a model of the selected particle type. Upon selection of images using the preferred CNN in processing additional electron micrographs, the selected images can be added to a training set or used as an additional training set to retrain the preferredCNN. In some examples, only selected layers of the preferred CNN are retrained. In other examples, two dimensional projections of based on particles of similar structure are used for CNN training orretraining.
Owner:FEI CO

Printing sheet and mold sheet for forming printing surface on the printing sheet

InactiveUS20140234580A1Preventing printed imagePrevent printed imageSpecial paperDuplicating/marking methodsElectron micrographsFiber
A printing sheet 1 comprising a base sheet 5 and an inorganic solidified matter layer 3 laminated on the surface of the base sheet 1, the surface 3a of the inorganic solidified matter layer 3 serving as the printing surface, wherein, in an electron microphotograph magnified by 100 times, the printing surface is a surface on where continuous flat surfaces and indefinite protuberances surrounded by said flat surfaces are present being mixed together, the protuberances being present at a ratio of 10 to 30% per a unit area and being observed having sizes or long diameters of 10 to 300 μm and in a number of 50 to 300 per 1 mm2. With this printing sheet, the fiber is effectively prevented from adhering on the surface of the inorganic solidified matter layer on which the printing is to be executed, and images can be finely printed maintaining in good quality without being blurred.
Owner:TOKUYAMA CORP

Productivity and bioproduct formation in phototropin knock/out mutants in microalgae

Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these processes include phototropism, chloroplast movement and stomatal opening. In the green alga Chlamydomonas reinhardtii, phototropin plays a vital role in progression of the sexual life cycle and in the control of the eye spot size and light sensitivity Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out (PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown cultures (500 μmol photons m−2 s−1). Our results indicate the up-regulation of genes involved in photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1,5-bisphosphate carboxylase / oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in starch and lipid synthesis. In addition, transmission electron micrographs show increased accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a pond environment. In conclusion, our studies suggest that phototropin may be a master gene regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in wild type strains.
Owner:NMC INC +1

Construction method and application of transgenic animal with increased blood-brain barrier permeability

The invention discloses a construction method and application of a transgenic mouse with increased blood-brain barrier permeability. The method for constructing transgenic engineering mice with increased blood-brain barrier permeability includes modifying the gene to increase the expression of slit protein, and obtaining a transgenic animal model with increased blood-brain barrier permeability. The study found that the overexpression of slit protein caused enlargement of the lateral ventricles of mice, severe damage to the structure of the choroid plexus, and loss of tight junctions of epithelial cells. Observing the vascular structure of the brain of Slit-Tg mice by immunofluorescence staining found that the cerebral vascular bifurcation was less, and the microvessels were more, and the shape of the blood vessels was incomplete and the distribution was irregular. Transmission electron micrographs also showed that the endothelial cells of Slit-Tg mice were damaged, extremely irregular, and the vascular basement membrane was incomplete. Evans? blue? The assay detected the increased permeability of the mice, indicating that the blood-brain barrier permeability of Slit-Tg mice was increased, which can be applied to the animal experiments of central nervous system drugs for the screening, development and efficacy evaluation of neurological drugs.
Owner:GUANGDONG PHARMA UNIV

Electron microscopy sample support including porous metal foil

An electron microscopy sample support comprises: a support member; and a metal foil comprising a porous region. The support member is configured to give structural stability to the metal foil, and theporous region of the metal foil is configured to receive an electron microscopy sample. Also provided is a method of manufacturing such an electron microscopy sample support, a method of imaging using such an electron microscopy sample support and an apparatus operable to perform such imaging. An electron microscopy specimen support in accordance with aspects and embodiments may reduce particle motion and / or sample charging in electron microscopy, thus improving information content available from electron micrographs. Appropriately designed and constructed supports may lead to an increased resolution per particle and increased accuracy of angular assignments in 3D reconstructions of for example, biological specimens. This may enable the determination of structures of smaller and more difficult proteins than was previously possible using EM techniques.
Owner:英国研究与创新署
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products