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4 results about "Gelsolin" patented technology

Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency. Gelsolin is located intracellularly (in cytosol and mitochondria) and extracellularly (in blood plasma).

Gel proteins and opioid tolerance

This invention relates to compositions and methods for treating opioid tolerance in subjects, and to methods for selecting pain relief treatment regimens for subjects suffering from and / or at risk of developing opioid tolerance. Embodiments of the treatment methods of this invention include administering a gelling agent to produce a therapeutic effect against opioid tolerance in the subject.
Owner:UNIV OF MARYLAND BALTIMORE

Application of tin-added ferruginine in clerodendrum trichotomum to preparation of medicine for reducing blood pressure and protecting blood vessels

The invention discloses application of tin-added ferruginine in clerodendrum trichotomum to preparation of a medicine for reducing blood pressure and protecting blood vessels. The tin-added ferruginine has a good antihypertensive effect and a target organ protection effect on L-NNA induced hypertension rats, has high efficiency and safety, has a multi-target regulation characteristic, is derived from natural products, has relatively low toxic and side effects, and has a unique advantage in treatment of hypertension.
Owner:GUIZHOU MEDICAL UNIV

Compositions and synergistic methods for treating infections

The present invention relates to compositions and methods for treating microbial infections in subjects, in particular methods of administering a gelsolin agent and an antimicrobial agent to produce a synergistic therapeutic effect against a microbial infection in a subject. The present invention also relates to methods for treating viral infections in subjects, including methods that include delayed-dosing methods and / or synergistic methods.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1