Fungicide composition

Abstract

The invention provides a fungicide composition containing an active component A and an active component B, and application thereof in preventing and controlling various agricultural fungal diseases. The active component A in the composition is one of two methoxyl acrylic ester compounds; and as shown above, the active component B of the compound A1 and the compound A2 is one of the following fungicide varieties: thiocarbamate compounds or salt thereof, aliphatic compounds or salt thereof, carbamate compounds or salt thereof, oxazole compounds or salt thereof, thiazole compounds or salt thereof, amide compounds or salt thereof, organophosphorus compounds or salt thereof, imidazole compounds or salt thereof, antibiotic compounds or salt thereof, pyridine compounds or salt thereof and triazole compounds or salt thereof.

Description

technical field

[0001] The invention belongs to the field of agricultural fungicides, and relates to a fungicide composition and its application for preventing and controlling agricultural diseases. Background technique

[0002] The mixed use of pesticides with a scientific basis can assist in solving new problems that cannot be solved or brought about by the single use of pesticides, so that the application of pesticides can obtain better economic, social and ecological benefits. Pesticide companies in Europe, America and other countries have many successful cases of pesticide mixed use. At present, there are many kinds of pesticides produced by pesticide manufacturers in my country, among which the mixed preparations of pesticides account for the majority. This plays a very important role in solving the problem of environmental pollution, controlling the problem of pest resistance, expanding the activity spectrum of a single agent and expanding the scope of application, a...

Examples

example 1

[0035] Example 1. Synthesis of intermediate (E)-1-(3-trifluoromethylphenyl)ethanone oxime

[0036]

[0037] Dissolve 1.9 g of m-trifluoromethyl acetophenone in ethanol, then add 1 g of hydroxylamine hydrochloride (dissolved in 2 ml of water), stir at room temperature, then add 0.6 g of sodium hydroxide (dissolved in 2 ml of water), and reflux reaction 2- After 4 hours, TLC detected that the reaction was complete, evaporated part of the solvent under reduced pressure, poured the reaction solution into ice water, added acetic acid to adjust the pH to about 6, precipitated a solid, filtered, washed with water, and rinsed with a small amount of ethanol to obtain the product.

example 2

[0038] Example 2. Compound A 1 Synthesis

[0039]

[0040] Dissolve 0.2 g of (E)-1-(3-trifluoromethylphenyl) acetoxime in 5 ml of N,N-dimethylformamide, add 0.10 g of 60% sodium hydride washed with petroleum ether, Stir for 0.5h. Add (E)-2-[2-(bromomethyl)phenyl]-3-methoxymethyl acrylate (prepared by known methods, see US4723034 and US5554578, etc.) 0.3g, and the reaction temperature is 40°C , stirred for 3h. After the reaction was monitored by TLC, the reaction solution was poured into 50 ml of saturated brine, extracted three times with 100 ml of ethyl acetate, and dried. After precipitation, it was purified by column chromatography (eluent: ethyl acetate and petroleum ether (boiling range: 60°C-90°C), volume ratio: 1:4, the same below) to obtain 0.18 g of viscous product.

[0041] NMR data ( 1 HNMR, 300MHz, internal standard TMS, solvent CDCl 3 )as follows:

[0042] δppm 2.26(3H, s), 3.69(3H, s), 3.82(3H, s), 5.17(2H, s), 7.18(1H, m), 7.34(2H, m), 7.50(2H, m), 7....

example 3

[0043] Example 3. Compound A 2 Synthesis

[0044]

[0045] Dissolve 0.2g trifloxystrobin in 5ml tetrahydrofuran, add dropwise a little excess of 25-30% methylamine aqueous solution, and then heat to reflux for 1h, after the reaction is monitored by TLC, desolventize, add water, and extract three times with 30ml ethyl acetate ,dry. After precipitation, the product was purified by column chromatography to obtain 0.16 g of an oily product.

[0046] NMR data ( 1 HNMR, 300MHz, internal standard TMS, solvent CDCl 3 )as follows:

[0047] δppm 2.22(3H, s), 2.95(3H, d), 3.95(3H, s), 5.14(2H, s), 6.75(1H, m), 7.20(1H, m), 7.37-7.52(4H, m ), 7.60 (1H, m), 7.79 (1H, m), 7.89 (1H, m).

[0048] Formulation example of the composition

[0049] The addition amount of each component is measured in parts by weight, wherein the active substance is the A and B components of the present invention and mixed and added according to the stated ratio.

[0050] Example 1. Preparation of 20% EC...

technical field

[0001] The invention belongs to the field of agricultural fungicides, and relates to a fungicide composition and its application for preventing and controlling agricultural diseases. Background technique

[0002] The mixed use of pesticides with a scientific basis can assist in solving new problems that cannot be solved or brought about by the single use of pesticides, so that the application of pesticides can obtain better economic, social and ecological benefits. Pesticide companies in Europe, America and other countries have many successful cases of pesticide mixed use. At present, there are many kinds of pesticides produced by pesticide manufacturers in my country, among which the mixed preparations of pesticides account for the majority. This plays a very important role in solving the problem of environmental pollution, controlling the problem of pest resistance, expanding the activity spectrum of a single agent and expanding the scope of application, a...

Examples

example 1

[0035] Example 1. Synthesis of intermediate (E)-1-(3-trifluoromethylphenyl)ethanone oxime

[0036]

[0037] Dissolve 1.9 g of m-trifluoromethyl acetophenone in ethanol, then add 1 g of hydroxylamine hydrochloride (dissolved in 2 ml of water), stir at room temperature, then add 0.6 g of sodium hydroxide (dissolved in 2 ml of water), and reflux reaction 2- After 4 hours, TLC detected that the reaction was complete, evaporated part of the solvent under reduced pressure, poured the reaction solution into ice water, added acetic acid to adjust the pH to about 6, precipitated a solid, filtered, washed with water, and rinsed with a small amount of ethanol to obtain the product.

example 2

[0038] Example 2. Compound A 1 Synthesis

[0039]

[0040] Dissolve 0.2 g of (E)-1-(3-trifluoromethylphenyl) acetoxime in 5 ml of N,N-dimethylformamide, add 0.10 g of 60% sodium hydride washed with petroleum ether, Stir for 0.5h. Add (E)-2-[2-(bromomethyl)phenyl]-3-methoxymethyl acrylate (prepared by known methods, see US4723034 and US5554578, etc.) 0.3g, and the reaction temperature is 40°C , stirred for 3h. After the reaction was monitored by TLC, the reaction solution was poured into 50 ml of saturated brine, extracted three times with 100 ml of ethyl acetate, and dried. After precipitation, it was purified by column chromatography (eluent: ethyl acetate and petroleum ether (boiling range: 60°C-90°C), volume ratio: 1:4, the same below) to obtain 0.18 g of viscous product.

[0041] NMR data ( 1 HNMR, 300MHz, internal standard TMS, solvent CDCl 3 )as follows:

[0042] δppm 2.26(3H, s), 3.69(3H, s), 3.82(3H, s), 5.17(2H, s), 7.18(1H, m), 7.34(2H, m), 7.50(2H, m), 7....

example 3

[0043] Example 3. Compound A 2 Synthesis

[0044]

[0045] Dissolve 0.2g trifloxystrobin in 5ml tetrahydrofuran, add dropwise a little excess of 25-30% methylamine aqueous solution, and then heat to reflux for 1h, after the reaction is monitored by TLC, desolventize, add water, and extract three times with 30ml ethyl acetate ,dry. After precipitation, the product was purified by column chromatography to obtain 0.16 g of an oily product.

[0046] NMR data ( 1 HNMR, 300MHz, internal standard TMS, solvent CDCl 3 )as follows:

[0047] δppm 2.22(3H, s), 2.95(3H, d), 3.95(3H, s), 5.14(2H, s), 6.75(1H, m), 7.20(1H, m), 7.37-7.52(4H, m ), 7.60 (1H, m), 7.79 (1H, m), 7.89 (1H, m).

[0048] Formulation example of the composition

[0049] The addition amount of each component is measured in parts by weight, wherein the active substance is the A and B components of the present invention and mixed and added according to the stated ratio.

[0050] Example 1. Preparation of 20% EC...

Images