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Collagen dressing for promoting wound healing and preparation method of collagen dressing

A technology of wound healing and collagen peptides, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of hindering the epithelialization of tissue cells, poor control of absorption time, and tensile strength Fast loss and other problems, to achieve the scientific and reasonable design of the preparation process, promote wound healing, and promote the effect of wound healing

Active Publication Date: 2018-02-02
河南东肽生物有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dressings have their own advantages and disadvantages. Gauze dressings will hinder the epithelialization of tissue cells and delay wound healing. Although biological dressings play an important role in the treatment of burns and skin grafts, they lose their tensile strength quickly in digestive juices and infection environments. , the absorption time is not well controlled
[0005] Chinese patent (CN102228715A) discloses a liquid dressing containing chitosan derivatives and its preparation method, and Chinese patent (CN104667335A) discloses a recombinant human collagen product with skin barrier function and its preparation method. Contains collagen, but because the molecular weight of collagen is too large, the solubility is small and the stability is poor. In addition, the liquid dressings use chemically synthesized preservatives and antibacterial agents, so the safety is also worth considering
Although the development of biological dressings is very rapid, none of the dressings can meet the requirements of ideal dressings, and all types of dressings have their insurmountable shortcomings

Method used

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  • Collagen dressing for promoting wound healing and preparation method of collagen dressing
  • Collagen dressing for promoting wound healing and preparation method of collagen dressing
  • Collagen dressing for promoting wound healing and preparation method of collagen dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A collagen peptide dressing that promotes wound healing is characterized in that the weight percentage of its components is as follows:

[0047] Bovine Collagen Oligopeptide 50%,

[0048] Modified chitosan solution 0.5%,

[0049] Sea cucumber oligopeptide 5%,

[0050] Ginseng Oligopeptide 5%,

[0051] Glycerin 10%,

[0052] The balance is solvent medical purified water.

[0053] Among them, bovine collagen oligopeptide is extracted from bovine bone, and its specific process is as follows:

[0054] ;

[0055] 1) High pressure cooking: the time is 5h. The pressure is 0.2MPa, the temperature is 100°C, and the ratio of solid to liquid is 1:20;

[0056] 2) Solid-liquid separation treatment: use filter cloth to filter for separation, and the filter cloth used is 200 mesh;

[0057] 3) Centrifugal separation: use 4000r / min, centrifuge for 10min;

[0058] 4) Enzymatic hydrolysis treatment: use alkaline protease (2.4AU / g, Novozymes, Denmark). The enzymatic hydrolysis ...

Embodiment 2

[0075] A kind of collagen peptide dressing that promotes wound healing, the weight percentage of its each composition is as follows:

[0076] Bovine collagen oligopeptide 60%,

[0077] Modified chitosan solution 1%,

[0078] Sea cucumber oligopeptide 10%,

[0079] Ginseng Oligopeptide 1%,

[0080] Propylene Glycol 10%,

[0081] The balance is solvent medical purified water.

[0082] Among them, bovine collagen oligopeptide is extracted from bovine bone, and its specific process is as follows:

[0083] ;

[0084] 1) High pressure cooking: the time is 6h. The pressure is 0.5MPa, the temperature is 120°C, and the ratio of solid to liquid is 1:20;

[0085] 2) Solid-liquid separation treatment: use filter cloth to filter for separation, and the filter cloth used is 200 mesh;

[0086] 3) Centrifugal separation: use 4000r / min, centrifuge for 10min;

[0087] 4) Enzymatic hydrolysis treatment: use neutral protease (0.8AU / g, Novozymes, Denmark). The enzymolysis conditions ar...

Embodiment 3

[0104] A kind of collagen peptide dressing that promotes wound healing, the weight percentage of its each composition is as follows:

[0105] Bovine Collagen Oligopeptide 50%,

[0106] Modified chitosan solution 2%,

[0107] Sea cucumber oligopeptide 5%,

[0108] Ginseng Oligopeptide 5%,

[0109] Propylene Glycol 10%,

[0110] The balance is solvent 30% ethanol-water solution.

[0111] Among them, bovine collagen oligopeptide is extracted from bovine bone, and its specific process is as follows:

[0112] ;

[0113] 1) High-pressure cooking: the time is 8 hours. The pressure is 0.5MPa, the temperature is 100°C, and the ratio of solid to liquid is 1:10;

[0114] 2) Solid-liquid separation treatment: use filter cloth to filter for separation, and the filter cloth used is 200 mesh;

[0115] 3) Centrifugal separation: use 4000r / min, centrifuge for 10min;

[0116] 4) Enzymolysis treatment: Alkaline protease (2.4AU / g, Novozymes, Denmark) and papain (2000U / g, Wolsen) were u...

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Abstract

The invention belongs to the technical field of medical treatment and discloses collagen dressing for promoting would healing. The collagen dressing is prepared from, by weight, 50-70% of bovine collagen oligopeptide, 0.5-5% of a modified chitosan solution, 5-20% of sea cucumber oligopeptide or cecropin B, 1-5% of ginseng oligopeptide, 0-20% of a wetting agent and the balances of solvents. A membrane is formed on the surface of the dressing to achieve antibacterial efficacy, high adhesion force is achieved, and long-acting antibacterial performance is achieved; meanwhile, infection can be isolated, and the novel liquid dressing has the advantages of biocompatibility, safety, antibacterial performance, would healing promotion and the like.

Description

technical field [0001] The invention belongs to the technical field of medical preparations, and in particular relates to a composition of a collagen peptide dressing for promoting wound healing and a preparation method thereof. Background technique [0002] Trauma can cause multiple hazards to the human body. After trauma, various injury factors produced by the body can cause acute respiratory distress syndrome; trauma can also directly damage the shape and function of organs or systems. After severe trauma, under conditions such as stress, shock and infection, The body releases a large amount of harmful mediators, and under the action of cascade amplification effect, it causes excessive inflammatory response, leading to aggravated tissue and organ damage and the occurrence of multiple organ failure (MODS). [0003] Surgical operations can artificially produce trauma, which is a stressful process for the body itself. However, if the wound does not heal well after the oper...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/36A61K38/01A61P17/02
CPCA61K9/7015A61K38/011A61K38/012A61K38/014A61K47/36A61K2300/00
Inventor 李勇樊蕊
Owner 河南东肽生物有限公司
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