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Bone repair support with self-repairing and anti-bacterial functions and manufacturing method of bone repair support

A production method and bone repair technology, which can be used in prosthesis, tissue regeneration, medical science, etc., can solve the problems of limited application, achieve high biocompatibility, improve biocompatibility, and resist bacterial infection

Active Publication Date: 2016-11-16
陕西东望科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the strength of many nano-hydroxyapatite-polymer composite bone repair materials currently under development and testing is still lower than that of cancellous bone, which limits its application to a large extent.

Method used

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  • Bone repair support with self-repairing and anti-bacterial functions and manufacturing method of bone repair support
  • Bone repair support with self-repairing and anti-bacterial functions and manufacturing method of bone repair support

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] A method for making a bone repair bracket with self-repair and antibacterial effects, comprising the following steps:

[0086] Step 1. Cultivating the patient's stem cells: taking the patient's bone marrow, isolating the patient's stem cells, and aseptically culturing the stem cells at 36°C;

[0087] Make the mesh hollow bracket body 1 with connection block 3 and fixing hole 4:

[0088] Obtain the bone model of the patient's lesioned wrist according to the medical image data, make a mesh hollow stent body 1 model that conforms to the shape and size of the patient's lesion, and add a connecting block 3 and a connection block 3 to the mesh hollow stent body 1 model Increase the fixing hole 4, and then print out the mesh hollow bracket body 1 with the connection block 3 and the fixing hole 4 by a metal 3D printer, and make it fit into the mesh hollow bracket body 1 and fit it with the mesh hollow bracket body 1 The metal 3D printer uses medical-grade titanium alloy materi...

Embodiment 2

[0099] A method for making a bone repair bracket with self-repair and antibacterial effects, comprising the following steps:

[0100] Step 1, making a mesh-shaped hollow support body 1 with connection blocks 3 and fixing holes 4, and culturing the patient's stem cells;

[0101] The step 1 of culturing the patient's stem cells is as follows: taking the patient's bone marrow, isolating the patient's stem cells, and aseptically culturing the stem cells at 36.5°C;

[0102] Step 1 Make a mesh hollow bracket body 1 with connecting blocks 3 and fixing holes 4. Specifically:

[0103] According to the medical imaging data, the bone model of the patient's lesioned ankle is obtained, and the mesh hollow bracket body 1 model conforming to the shape and size of the patient's lesion is made, and the connection block 3 and the connection block 3 are added to the mesh hollow bracket body 1 model. Fix the hole 4, and then print out the mesh hollow bracket body 1 with the connecting block 3 an...

Embodiment 3

[0117] A method for making a bone repair bracket with self-repair and antibacterial effects, comprising the following steps:

[0118] Step 1, making a mesh-shaped hollow support body 1 with connection blocks 3 and fixing holes 4, and culturing the patient's stem cells;

[0119] The step 1 of culturing the patient's stem cells is as follows: taking the patient's bone marrow, isolating the patient's stem cells, and aseptically culturing the stem cells at 37°C;

[0120] Step 1 Make a mesh hollow bracket body 1 with connecting blocks 3 and fixing holes 4. Specifically:

[0121] Obtain the bone model of the femoral part of the patient's lesion according to the medical image data, make a mesh hollow stent body 1 model that conforms to the shape and size of the patient's lesion, and add a connecting block 3 and a connection block 3 to the mesh hollow stent body 1 model Increase the fixing hole 4, and then print out the mesh hollow bracket body 1 with the connection block 3 and the f...

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Abstract

The invention discloses a bone repair support with self-repairing and anti-bacterial functions and a manufacturing method of the bone repair support with the self-repairing and anti-bacterial functions. Rehabilitation time of a patient can be shortened by the bone repair support. The manufacturing method includes the steps: 1 manufacturing a netted hollowed-out support body with connecting blocks and fixing holes to culture stem cells of the patient; 2 preparing anti-bacterial porous nano-hydroxyapatite composite materials; 3 filling the anti-bacterial porous nano-hydroxyapatite composite materials in hollowed-out positions of the netted hollowed-out support body; 4 uniformly inoculating the cultured stem cells of the patient on the anti-bacterial porous nano-hydroxyapatite composite materials and then performing aseptic packaging to obtain the bone repair support with the self-repairing and anti-bacterial functions. The bone repair support prepared by the method can realize self-repairing and resist bacterial infection in the body of the patient.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a bone repair bracket with self-repair and antibacterial functions, and also relates to a manufacturing method of the bracket. Background technique [0002] It is clinically found that after bone repair materials are implanted into the body, bacteria are easy to colonize on the surface of the implanted materials, which often leads to bacterial infection related to the implanted materials, affects the benign interaction between the surrounding cells and tissues and the materials, and even causes bone loss, resulting in Bone repair fails. Once an infection occurs, it is difficult for patients to effectively treat it even if they take orally or inject large doses of antibiotics, and the abuse of antibiotics is continuously increasing bacterial resistance. Therefore, the development of bone repair materials with antibacterial and anti-infection properties ha...

Claims

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Application Information

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IPC IPC(8): A61L27/38A61L27/24A61L27/18A61L27/12A61L27/06A61L27/58A61L27/54A61L27/50A61L27/56
CPCA61L27/06A61L27/12A61L27/18A61L27/24A61L27/3834A61L27/3847A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/104A61L2300/404A61L2430/02C08L89/00C08L67/04
Inventor 陈卫
Owner 陕西东望科技有限公司
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