4 results about "Cannabidivarin" patented technology

The present invention relates to the use of cannabidiol (CBD) in the treatment of patients with childhood-onset epilepsy who are concurrently taking caffeine. Where the CBD is used in combination with caffeine, caution should be taken. For example, the dose of either the CBD and / or caffeine may be required to be reduced. Moreover, the patient may need to be monitored for side effects of said drug-drug interaction. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 95% of the total extract (w / w) and the other components of the extract are characterised. In particular the cannabinoid tetrahydrocannabinol (THC) has been substantially removed, to a level of not more than 0.15% (w / w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD.

The present invention relates to the use of cannabidivarin (CBDV) for the treatment of seizures associated with rare epilepsy syndromes. In particular, the seizures associated with rare epilepsy syndromes to be treated are those experienced by patients diagnosed with Rett syndrome. In a further embodiment, the types of seizures include focal motor seizures with functional impairment, focal non-motor seizures with functional impairment, generalized motor seizures, generalized non-motor seizures, motor seizures of unknown onset, and non-motor seizures. Preferably, the dose of CBDV is between 2.5 mg / kg / day and 10 mg / kg / day.

The application discloses a method for effectively separating cannabidiol, cannabidivarin and tetrahydrocannabinol. The application uses a chromatographic separation and purification method, uses a coordination resin as a filler, and uses a mixed solution of polar and non-polar solvents as an eluent, so as to separate a cannabidiol pure product with a purity of greater than or equal to 99% from a cannabidiol crude product. The cannabidiol and the analogs tetrahydrocannabinol and cannabidivarin are completely separated by one-step purification. The ligand in the coordination resin is used to form a coordination complex with CBD, so that the retention time difference between CBD, THC and CBDV is increased, and thus a good separation effect is achieved. The CBD, CBDV and THC can be completely separated by selecting specific coordination resins and specific elution conditions, and the separation selectivity is good. The purity of the cannabidiol obtained by the separation method can be higher than 99%, the yield can be higher than 80%, and the separation method is suitable for the separation and purification of high-purity CBD.