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Composition containing cannabidiol and/or cannabidivarin and application of composition in treatment of dysmenorrhea

A technology of secondary cannabidiol and cannabidiol, which can be applied to medical preparations containing active ingredients, drug combinations, active ingredients of hydroxyl compounds, etc. And other issues

Inactive Publication Date: 2019-03-22
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Although a series of pharmaceutical compositions containing cannabidiol and / or cannabidiol have been developed, none of the existing compositions can meet the treatment requirements for female dysmenorrhea
For example, CBD in oral medicine cannot be quickly absorbed and released at the desired site; sprays or aerosols often contain irritating excipients, and at the same time cannot achieve the purpose of continuous drug delivery; alcohol in traditional Chinese medicine liquor can irritate the stomach Mucous membranes, harm the central nervous system, especially for underage women and women in the student stage, alcohol will affect physical development and learning status

Method used

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  • Composition containing cannabidiol and/or cannabidivarin and application of composition in treatment of dysmenorrhea
  • Composition containing cannabidiol and/or cannabidivarin and application of composition in treatment of dysmenorrhea
  • Composition containing cannabidiol and/or cannabidivarin and application of composition in treatment of dysmenorrhea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Extraction of cannabidiol

[0043] 1) Wash and air-dry the raw material cannabis flowers and leaves;

[0044] 2) pulverize the above-mentioned air-dried raw materials to 40 mesh;

[0045] 3) adding 8 times the amount of 95% ethanol to the obtained powder and extracting by cold soaking for 3 times, each time for 1 hour;

[0046] 4) Combine extracts and decolorize;

[0047] 5) concentrated under reduced pressure to a relative density of 1.05;

[0048] The obtained cannabidiol extract, wherein the cannabidiol content is 99.5% by mass percentage.

[0049] It should be noted that the descriptions such as "8 times the amount" in the present invention mean that the volume of the extraction solvent used is 8 times the mass of the extraction part. For example, the extraction part of cannabis is 1g, and the amount of extraction solvent is 8ml.

Embodiment 2

[0050] Example 2 Extraction of cannabidiol

[0051] 1) Wash and air-dry the raw material cannabis flowers and leaves;

[0052] 2) pulverize the above-mentioned air-dried raw materials to 40 mesh;

[0053] 3) Add 10 times the amount of absolute ethanol to the obtained powder according to the mass volume ratio and extract by cold soaking for 3 times, each time for 1 hour;

[0054] 4) Combine the extracts, decolorize and concentrate;

[0055] 5) Take column chromatography, use silica gel as a packing column, load the extract through the column, the mobile phase is petroleum ether and diethyl ether at 80:20, and the flow rate is 3.0ml / min;

[0056] 6) Collect the effluent containing the cannabidiol component, and remove the solvent by rotary evaporation to obtain a cannabidiol extract, wherein the cannabidiol content is 97.5% by mass percentage.

Embodiment 3

[0057] Example 3 Preparation of an external patch for preventing and / or treating female dysmenorrhea

[0058] An external drug for preventing and / or treating female dysmenorrhea, the external drug is a patch-like external drug, the backing layer is non-woven fabric, the protective layer is anti-sticking paper, and the cannabidiol and stimulant in the drug storage layer The mass ratio of the penetrating agent is 1:0.5, the penetrating agent is ginger oil, the carrier of the drug storage layer is a polymer hydrogel, and the mass ratio of cannabidiol to the carrier is 1:4, and the high Molecular hydrogel is made by mixing sodium carboxymethyl cellulose, glycerin, water and aluminum oxide at a mass ratio of 10:30:40:0.1.

[0059] Mix cannabidiol and ginger oil, then mix with polymer hydrogel, then pour the mixture into a coating machine, evenly coat the non-woven fabric of the backing layer, and then cover with a protective layer Release paper, that is, to make a patch.

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Abstract

The invention discloses a composition for preventing and / or treating female dysmenorrhea. The composition is prepared from cannabidiol and / or cannabidivarin, a penetration enhancer and a carrier, wherein the mass ratio of the cannabidiol and / or cannabidivarin to the penetration enhancer is 1:(0.1-0.8). The composition has the advantages that the female dysmenorrheal can be effectively relieved, and the problem that in the prior art, a cannabidiol and / or cannabidivarin composition capable of effectively preventing and / or treating the female dysmenorrhea is in shortage can be solved; and meanwhile, the composition can also be used for preparing female hygienic aids for preventing and / or treating the female dysmenorrhea.

Description

technical field [0001] The present invention relates to a composition containing cannabidiol and / or cannabidiol, in particular to a composition containing cannabidiol and / or cannabidiol in the preparation of externally used medicines for preventing and / or treating female dysmenorrhea and applications in feminine hygiene products. Background technique [0002] Dysmenorrhea is a common and frequently-occurring disease in gynecology. It has many causes, complex pathogenesis, high recurrence, and difficult treatment. It is especially common in unmarried women and young girls in the early menstruation. Cold pain, burning pain, tingling pain, dull pain, falling pain, cramping pain, spasmodic pain, tearing pain, pain extending to the sacrum and back, even involving thighs and feet, and even accompanied by systemic symptoms, seriously affecting women's Work and study reduce the quality of life. [0003] In clinical experience, Chinese medicine uses "soothing the liver and relievin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P15/00A61P29/00A61P1/08A61P25/00A61P1/12A61P1/14A61P7/06A61P39/00A61L15/44A61L15/20
CPCA61L15/20A61L15/44A61K31/05A61L2300/216A61L2300/402A61K2300/00A61K9/06A61K9/127A61K9/70A61K31/352A61P15/00A61P29/02A61F13/472A61F2013/4708A61K9/7023
Inventor 于朝晖张可谭昕
Owner HANYI BIO TECH CO LTD
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