Preparation method of special chromatographic medium for separating cannabidiol
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of cannabidiol and cannabidiol, which is applied in the field of chromatographic media, can solve the problems of low yield, cumbersome steps, and inability to produce in large quantities, and achieve the effects of high purity, simple process, and easy operation
Pending Publication Date: 2022-06-10
SOOCHOW HIGH TECH CHROMATOGRAPHY
View PDF7 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0008] There are many deficiencies in the existing process for producing cannabidiol, such as low yield, cumbersome steps, and inability to prepare in large quantities.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0032] The specific steps of the present invention are as follows:
[0033] (1) Take 15g of monoplasmic bromine, 3g of cannabidiol, 0.1g of glacial acetic acid, mixed reaction;
[0034] (2) Weigh 30g of porous amino silicon balls with a particle size of 50 μm, add to xylene, stir well to make it completely wet;
[0035] (3) Brominated hypocandiol intermediates and 0.1g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide were then added to the above solution, 75 °C reaction.
[0036] After the reaction is completed, it is filtered and dried, that is, the special chromatographic separation medium is obtained and the column is loaded.
[0037] Pillar: 15×310mm, 50 μm,
[0038] Wavelength: 210nm
[0039] Mobile phase: methanol - water
[0040] Flow rate: 10.6ml / min
[0041] Take 10 g of crude hypocandiol extracted by solvent method and analyze it with C18 reversed-phase column, see Figure 3 。 Separation and purification of subnabinol was performed with a loaded preparative column to obtain 1...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
particle diameter
aaaaa
aaaaa
wavelength
aaaaa
aaaaa
Login to view more
Abstract
The invention relates to a preparation method of a special chromatographic medium for separation of sec-cannabidiol, which comprises the following steps: (1) reacting elemental bromine, sec-cannabidiol and a catalyst to obtain a brominated sec-cannabidiol intermediate; (2) adding a certain amount of porous amino silicon balls into an organic solvent, and fully stirring to completely wet the porous amino silicon balls; and (3) adding the brominated cannabidiol intermediate and a catalyst into the solution, and heating to react. And after the reaction is finished, filtering and drying to obtain the special chromatographic separation medium. According to the invention, secondary cannabidiol is bonded to a silicon ball to form the surface modified silica gel chromatographic filler; the medium has high-selectivity adsorption retention on the cannabidiol, has the advantages of good selectivity and low cost, and is suitable for industrial purification of the cannabidiol.
Description
Technical field [0001] The present invention relates to the field of chromatographic media technology, in particular, is a preparation method of a special chromatographic medium for the separation of hypocandiol. Background [0002] Cannabis is a cannabis family, cannabis plants, commonly known as hemp, line hemp, hemp, cultivation history, has an important agricultural and medicinal value, cannabis contains a toxic ingredient tetrahydrocannabinol (THC) can make people hallucinogenic addiction, often used by people to refine drugs, has been banned for a long time. [0003] Cannabis is now widely recognized as having significant benefits for a variety of medical uses, such as cannabis is often widely used by society to treat a variety of diseases, diseases, and symptoms, including nausea, pain, glaucoma, loss of appetite, mucosal inflammation, neurodegenerative diseases, epilepsy, diabetes, leprosy, etc., as well as the usual fever, cough, obesity, asthma, urinary tract infections...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more