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Cannabinoids for use in the treatment of neuropathic pain

a neuropathic pain and cannabis technology, applied in the field of cannabis for use in the treatment of neuropathic pain, can solve the problems of increasing or prolonging pain, increasing pain, and affecting the treatment effect of neuropathic pain, and achieve the effect of relieving neuropathic pain

Active Publication Date: 2014-12-25
GW PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pain is one of the most common reasons for a patient to seek medical care and in consequence, pain results in a tremendous number of lost work days per year.
Such pain often occurs after injury or surgery.
Some types of mental or emotional problems can cause pain.
They can also increase or prolong pain.
Neuropathic pain is frequently chronic and is often refractory to treatment with opioids.
The most common cause of neuropathic pain is injury or dysfunction of nerves.
Injury or dysfunction of peripheral nerves or nerves descending from the spinal cord results in disinhibition of nerve impulses at the spinal cord which in consequence results in pain.
The pain can interfere with work and social activities as well as with the amount and quality of sleep that a patient experiences.
Neuropathic pain is often associated with a diverse and complex set of pain stimuli and as such is difficult to treat effectively as the response to treatment is unpredictable.

Method used

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  • Cannabinoids for use in the treatment of neuropathic pain
  • Cannabinoids for use in the treatment of neuropathic pain
  • Cannabinoids for use in the treatment of neuropathic pain

Examples

Experimental program
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Effect test

example 1

The Effects of Cannabinoids in Two Animal Models of Neuropathic Pain

Materials and Methods

[0048]The cannabinoids tested were CBG, CBC, CBDV, and THCV. In addition the cannabinoid CBD was used as this cannabinoid has previously demonstrated positive results in the animal models of neuropathic pain used in this example. The cannabinoids were prepared from whole plant extracts of cannabis plants which had been purified. The cannabinoids were dissolved in ringer / 0.5% dimethyl sulfoxide (DMSO), for intraperitoneal (i.p.) administration.

[0049]Male CD-1 mice (35-40 g) were housed, 3 per cage, under controlled illumination (12:12 h light: dark cycle; light on 06.00 h) and environmental conditions (room temperature 20-22° C., humidity 55-60%) for at least 1 week before the commencement of experiments. Mouse chow and tap water were available ad libitum. The experimental procedures were approved by the Ethic Committee of the Second University of Naples. Animal care was in compliance with the IA...

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Abstract

The present invention relates to cannabinoids for use in the treatment of neuropathic pain. Preferably the cannabinoids are one or more phytocannabinoids of: cannabigerol (CBG), cannabichromene (CBC), cannabidivarin (CBDV) or tetrahydrocannabivarin (THCV). More preferably the phytocannabinoids are isolated and / or purified from cannabis plant extracts.

Description

[0001]The present invention relates to cannabinoids for use in the treatment of neuropathic pain. Preferably the cannabinoids are one or more phytocannabinoids of: cannabigerol (CBG), cannabichromene (CBC), cannabidivarin (CBDV) or tetrahydrocannabivarin (THCV). More preferably the phytocannabinoids are isolated and / or purified from cannabis plant extracts.BACKGROUND TO THE INVENTION[0002]Pain is one of the most common reasons for a patient to seek medical care and in consequence, pain results in a tremendous number of lost work days per year. There are three general classes of pain: nociceptive pain, neuropathic pain, and psychogenic pain. FIG. 1 illustrates the relationship between different types of pain and conditions affected, such as allodynia and multiple sclerosis.[0003]In nociceptive pain, the stimulation of the sensory nerve endings called nociceptors cause the sensation of pain. Such pain often occurs after injury or surgery. The pain signals are transmitted by the nocice...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/352A61K31/05
CPCA61K31/05A61K31/352A61P25/02A61P25/04A61P29/02A61K31/185
Inventor MAIONE, SABATINOROSSI, FRANCESCOGUY, GEOFFREYSTOTT, COLINKIKUCHI, TETSURO
Owner GW PHARMA LTD
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